Virus-specific T-cells
Anatomy of viral persistence.
... persistent virus infection or a controlled acute virus infection in immunocompetent ...Dendritic cells (DC) present viral peptide/MHC complexes to activate T ...the virus or ...
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Virus-specific regulatory T cells ameliorate encephalitis by repressing effector T cell functions from priming to effector stages.
... Tregs specific for epitopes present at sites of autoimmune inflammation diminish disease more effectively than bulk Treg populations ...Tregs specific for a virus-specific CD4 T cell ...
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Combining regulatory T cell depletion and inhibitory receptor blockade improves reactivation of exhausted virus-specific CD8+ T cells and efficiently reduces chronic retroviral loads.
... these cells might be able to inhibit effector T cells by direct interaction of their ligands with inhibitory ...of T cell exhaustion and that blocking both pathways has an additive therapeutic ...
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HIV-specific T-cell responses, T-cell activation and regulatory T-cells in AIDS pathogenesis : lessons from the HIV-2 model
... isolating virus from samples obtained from HIV-2 infected ...+ T-cell depletion, although occurring at a slower rate in HIV-2 infection as compared to progressive HIV-1 infection, is still continuous: 49 ...
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Microbial Translocation and B Cell Dysfunction in Human Immunodeficiency Virus Disease
... the specific memory (with B cell receptor signals) built up by previous experience and vaccination and IgM antibodies may represent first-line memory, indispensable against pathogens never encountered before and ...
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The antiviral efficacy of simian immunodeficiency virus-specific CD8(+) T cells is unrelated to epitope specificity and is abrogated by viral escape
... T lymphocytes to recognize variant peptides by using gamma interferon (IFN-␥) production as the readout, providing encouragement that the immune system may be able to cope with viral escape (22, 24, 46, 64). ...
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Immunophenotype and TCR‐Vbeta repertoire of peripheral blood T‐cells in acute infectious mononucleosis.
... ⫹ T-cells showed a TCR-V ␥/V␦ distribution similar to that of normal TCR ␥␦ ⫹ T-cells, small expansions of specific TCR-V  families were found in both the CD8 ⫹ and CD4 ⫹ /TCR ␣ ⫹ ...
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Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells.
... A9 cells [15,16,17]. NIH 3T3 cells expressing hCD4/CCR5/Cyclin T1 supported HIV-1 entry and ...integration. Virus assembly was reported to be a major post-integration block, which could be relieved ...
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Influenza-specific T cells from older people are enriched in the late effector subset and their presence inversely correlates with vaccine response.
... RNA virus that infects lung epithelial cells; binding is mediated through influenza surface hemagglutinin (HA) ...a specific strain, these antibody responses are generally not cross-reactive with ...
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CD160-associated CD8 T-cell functional impairment is independent of PD-1 expression.
... CD8 T-cell proliferation capacity is one of the first function lost during CD8 T-cell functional impairment ...CMV- specific CD8 T cells was then assessed using the CFSE flow cytometry ...
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Generalized Liver- and Blood-Derived CD8+ T-Cell Impairment in Response to Cytokines in Chronic Hepatitis C Virus Infection.
... + T-cells isolated from individuals with HCV infection exhibit significantly impaired responsiveness to IL-7, independent of CD127 expression, and this was widespread, as detected in bulk blood-derived and ...
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NY-ESO-1-specific circulating CD4+ T cells in ovarian cancer patients are prevalently T(H)1 type cells undetectable in the CD25+ FOXP3+ Treg compartment.
... develop specific spontaneous antibody (Ab) responses ...ESO-specific cells within defined circulating memory CD4 + T-cell subsets of these patients, we isolated them ...
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Desdobramentos dos surtos de infecção pelo vírus Zika
... Abstract: The Zika virus (ZIKV) is an emerging arthropod-borne virus has only recently been exposed as a substantial public health threat. The outbreak of the ZIKV in Brazil, specially, and its association ...
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Autocrine production of beta-chemokines protects CMV-Specific CD4 T cells from HIV infection.
... sorting cells were centrifuged in ...added. Cells were then incubated at 56uC for 1 hour, and then at 90uC for 10 ...4B). Cells were sorted in the following manner: Single cells were sorted ...
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The role of human T cell lymphotrophic virus type 1, hepatitis B virus and hepatitis C virus coinfections in leprosy
... A study of survival of 327 leprosy inpatients in the Congo over a 22 year period showed that HTLV-1 coin- fection was associated with an increased mortality rate of 5.5/100 person years compared to 3.6/100 person years ...
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Vacinas em forma inativada e atenuada contra vírus influenza induzem diferente resposta celular imune e perfil de expressão gênica em crianças
... To better unoerstano the oifferences of immune relateo genes inouceo by both vaccines, we useo an analytical framework of transcriptional mooules that share a biological function as previously oescribeo [22, 23]. Gene ...
100
Rev. Soc. Bras. Med. Trop. vol.41 número3
... ATLL cells express receptor activator of NF- B ligand (RANKL), which induces differentiation of stem cells into osteoclasts, with consequently increased bone ...neoplastic cells stimulate parathyroid ...
5
In TCR-stimulated T-cells, N-ras regulates specific genes and signal transduction pathways.
... exchanger that localizes to sorting/recycling endosomes, where it functions in apical surface protein recycling and sorting through a fine-tuning of the luminal pH of the endosomal compartment [27,28]. In clinical ...
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A convenient model of severe, high incidence autoimmune gastritis caused by polyclonal effector T cells and without perturbation of regulatory T cells.
... by T cells with a single specificity as observed in TCR transgenic mice does not resemble normal physiological ...of T cells from H/Ka 2/2 mice, a ...
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The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription.
... of cells infected with VIC influenza ...infected cells we carried out co-immunoprecipitation ...A549 cells were infected at high moi with the VIC strain of influenza virus and at various times ...
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