[PDF] Top 20 The effects of local ischemic preconditioning and topical hypothermia in renal ischemia/reperfusion injury in rats

... USA). In groups exposed to TH (TH, TH+IR and IPC+TH+IR groups), the left kidney target- temperature (4°C) was achieved with ice slush of saline ...systemic hypothermia, a suction system ... See full document

... application of ischemic conditioning in a remote organ can induce the release of humoral factors - such as adenosine, bradykinin and opioids - that under local ... See full document

... used and to confirm normal distribution samples by Kolmogorov- Smirnov ...to renal function and oxidative stress, whereas the histopathological parameters by Kruskal- Wallis with post hoc ... See full document

... Ischemia-reperfusion injury (I/R) is a major cause of morbidity and mortality in liver surgery and ...transplantation. In order to attenuate the deleterious ... See full document

... considering the oxygen consumption in state 3 of mitochondrial respiration, there was no significant difference between the group that underwent ischemia and reperfusion ... See full document

... investigated the expressions of key apoptotic-related ...findings and further supported our ...increased the levels of anti-apoptotic Bcl-2 protein and inhibited the ... See full document

... that the effects of iNOS expression on liver I/R injury might be dependent on the duration of liver ...ischemia. In the present study, down-regulation ... See full document

... by ischemia/reperfusion may trigger mechanisms of renal preconditioning, reducing histological lesions and preserving or facilitating recovery of renal function ... See full document

... SOD, and GPx in living tissues are very important antioxidant defense ...for the detoxification of H2O2, SOD catalyzes the O2- radical, otherwise the biological structure ... See full document

... remote effects of AKI in the lungs are due to multiple distinct mechanisms: uncontrolled inflammatory cascade, oxidative stress, apoptosis, lung leukocyte activation and trafficking, ... See full document

... Renal ischemia and reperfusion injury (IRI), which usually occurs in patients undergoing kidney transplantation, can increase the rates of acute kidney failure, ... See full document

... using the SigmaStat statistical program, version ...CA). The groups were compared by Kruskal-Wallis 1-way analysis of variance on ranks, after testing for normality and variance equality, ... See full document

... with the induction of inhalation general anesthesia with an isoflurane vaporizer at 3-5%, administrated through a ...from the retro-orbital plexus. The animals were placed on a warm surgical ... See full document

... reviewed the various publications and selected serum lactate and LDH values as biochemical parameters in demonstrating the possible protective effects of both ... See full document

... is the activation of a neurohumoral pathway against the reperfusion injury of organs submitted to ischemia 22 .... The addition of remote ischemic ... See full document

... assessed the effect of different concentra- tions of fentanyl preconditioning on cardiomyocyte apop- tosis induced by I/R in ...study and our heart function results showed that, ... See full document

... production of ROS in ischemia-reperfusion causes to a considerable oxidative stress as indicated by lipid peroxidation 3 ...radicals and hydrogen peroxide called as ROS are produced as ... See full document

... Fragments of liver were fixed in 10% buffered formalin, pH 7.4, embedded in paraffin, sectioned into 5 μm slices, and stained with hematoxylin-eosin (HE), using standard histological ...random ... See full document

... (n=8 in each group): thera- peutic hypothermia group (TH group), normothermia group (NH group) and sham operation group (SHAM ...minutes of untreated VF, CPR was performed. Upon ROSC, ... See full document

... fixed in Bouin’s solution ...acid, and 2.5 mL 7% formaldehyde), post-fixed in 70% alcohol, and embedded in paraffin ...deparaffinized, and stained with hematoxylineeosin. ... See full document