[PDF] Top 20 Frequency of first and second-line drug resistance-associated mutations among resistant Mycobacterium tuberculosis clinical isolates from São Paulo, Brazil
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Frequency of first and second-line drug resistance-associated mutations among resistant Mycobacterium tuberculosis clinical isolates from São Paulo, Brazil
... best of our knowledge, this is the first report describing the frequency of mutations related to second- line drug resistance in TB patients from the ... See full document
10
Drug Resistance and Genotypes of Strains of Mycobacterium tuberculosis Isolated from Human Immunodeficiency Virus- infected and Non-infected Tuberculosis Patients in Bauru, São Paulo, Brazil
... value of the IS6110-RFLP as an additional tool for epidemological studies of TB in Brazil has already been demonstrated (Suffys et ...2000) and both IS6110 copy number and genetic ... See full document
6
HCV Genotypes, Characterization of Mutations Conferring Drug Resistance to Protease Inhibitors, and Risk Factors among Blood Donors in São Paulo, Brazil
... frequent among younger donors and subtype 3a in donors older than 40 ...part from another study also performed in Sa˜o Paulo that reported that subtypes 1a and 3a appear to be more ... See full document
9
Mutations in the rpoB gene of rifampicin-resistant Mycobacterium tuberculosis strains isolated in Brazil and France
... In Brazil, tuberculosis incidence is higher in urban areas such as the States of Rio de Janeiro ...(120/100.000) and São Paulo (80/ ...increase of tuberculosis abandon ... See full document
4
Anti-Tuberculosis Drug Resistance in Strains of Mycobacterium tuberculosis Isolated from Patients in a Tertiary Hospital in Bahia
... state of Rio Grande do Norte, in the Northeastern Brazil (the same geographic area as the state of Bahia), a study involving patients in a tertiary reference center (n=72) reported prevalence rates ... See full document
8
Carbapenem-resistant and cephalosporin-susceptible: a worrisome phenotype among Pseudomonas aeruginosa clinical isolates in Brazil
... uncommon resistance phenotype, carbapenem resistance and broad-spectrum cephalosporin susceptibility, were investigated in 25 Pseudomonas aeru- ginosa clinical isolates that exhibited ... See full document
6
Screening and characterization of mutations in isoniazid-resistant Mycobacterium tuberculosis isolates obtained in Brazil
... (each) of dATP, dCTP, dGTP, and dTTP; 100 nM concentrations (each) of the primers; 1 U of DNA polymerase (Biotools/B&M Laboratories, ...Sa˜o Paulo, Brazil); and 1 l ... See full document
10
Comparison of resazurin microtiter assay performance and BACTEC MGIT 960 in the susceptibility testing of Brazilian clinical isolates of Mycobacterium tuberculosis to four first-line drugs
... underdeveloped and developing countries (Sanchotene et ...incidence of drug re- sistant TB gives cause for concern around the world (WHO, ...Currently, Brazil occupies the 19th position ... See full document
5
Molecular profiling of drug resistant isolates of Mycobacterium tuberculosis in the state of Santa Catarina, southern Brazil
... Drug resistance is a global threat and one of the main contributing factors to tuberculosis (TB) ...goal of this study was to analyse the molecular profile of ... See full document
6
Epidemiology and Clinical Characteristics of Pediatric Drug-Resistant Tuberculosis in Chongqing, China.
... epidemiology of childhood drug resistant tuberculosis (DR-TB) in China that has the second largest burden of TB and the largest number of multidrug resis- tant ... See full document
12
Genome Analysis of the First Extensively Drug-Resistant (XDR) Mycobacterium tuberculosis in Malaysia Provides Insights into the Genetic Basis of Its Biology and Drug Resistance.
... clade of East Asian lineage 2 which is very close to the Beijing ...tor of the Beijing clade. However, at this stage of knowledge, its evolutionary origin and history is only partially ... See full document
20
Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium
... rifampicin and clofazimine (da Silva et ...2011); and the EfpA efflux transporter that is associated with resistance to isoniazid, fluoroquinolones and dyes (Doran et ...are ... See full document
18
COMPARATIVE EVALUATION OF THE NITRATE REDUCTASE ASSAY AND THE RESAZURIN MICROTITRE ASSAY FOR DRUG SUSCEPTIBILITY TESTING OF MYCOBACTERIUM TUBERCULOSIS AGAINST FIRST LINE ANTI-TUBERCULOSIS DRUGS
... disease of worldwide distribution, with high morbidity and mortality, mainly in low socio-economic condition ...state of emergency of tuberculosis caused by the resistant ... See full document
5
Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil
... ofloxacin resistance in multidrug resistant M. tuberculosis strains, as previously shown (Machado, ...2014). Resistance to isoniazid was only moderately reduced, as these isoniazid ... See full document
12
A population-based study of first and second-line drug-resistant tuberculosis in a high-burden area of the MexicoUnited States border
... The resistance of 139 Mycobacterium tuberculosis (MTB) isolates from the city of Monterrey, Northeast Mexico, to first and second-line anti-TB ... See full document
7
Characterization of ndh gene of isoniazid resistant and susceptible Mycobacterium tuberculosis isolates from Brazil
... a first-line drug for tuber- culosis treatment for many years and yet its mechanism of action remains only partially understood (Rozwarski et ...that mutations in katG and ... See full document
3
Molecular characterization of pre-extensive drug resistant Mycobacterium tuberculosis in Northeast Brazil
... anti-Mycobacterium tuberculosis drugs is mainly caused by spontaneous mutations in drug- directed chromosomal genes or drug-modifying enzyme- related ...presence of specific ... See full document
10
Analysis of drug resistance mutations in pulmonary Mycobacterium tuberculosis isolates in the Southern coastal region of Andhra Pradesh, India
... one of the largest south- ern states in India and it records 1, 07,293 patients, annually, enrolled under RNTCP program for TB treat- ment with ...8% of the suspected harboring MDR TB ...the ... See full document
10
Clinical data and molecular analysis of Mycobacterium tuberculosis isolates from drug-resistant tuberculosis patients in Goiás, Brazil
... evolution of drug resistance patterns observed in the M. tuberculosis isolates from patients 4 and 8 was unexpected, as it went from an MDR to a monoresis- tance ... See full document
7
Molecular and genomic epidemiology of multidrug resistant Mycobacterium tuberculosis isolates in Lisbon, Portugal
... mortality and HIV coinfection rate across the different WHO Regions in ...extracted from the WHO surveillance ...habitants) and tendency across the European Region between ...extracted from ... See full document
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