[PDF] Top 20 HIV drug resistance mutations in proviral DNA from a community treatment program.
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HIV drug resistance mutations in proviral DNA from a community treatment program.
... recommend drug switching with VL measures based on a single value between 50 and 1,000 copies/ml ...DRM in 5 of 9 from both components, and those with DRM in the plasma had similar DRM ... See full document
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Virologic failure of protease inhibitor-based second-line antiretroviral therapy without resistance in a large HIV treatment program in South Africa.
... Data from HIV-infected patients $15 years of age who had failed second-line therapy (2 consecutive HIV-1 RNA tests ...performed HIV-1 RNA assays by branch DNA hybridization techniques ... See full document
5
The role of compensatory mutations in the emergence of drug resistance.
... of Drug Resistance A number of theoretical between-host studies have provided some insights into prudent drug ...between drug use and levels of resistance for the community at ... See full document
9
Virological failure and HIV-1 drug resistance mutations among naive and antiretroviral pre-treated patients entering the ESTHER program of Calmette Hospital in Cambodia.
... of drug resistance mutations in adults and children from this southeastern Asian country where CRF01_AE is the most common HIV ...on treatment failure for this specific ... See full document
9
An overview of the molecular and epidemiological features of HIV-1 infection in two major cities of Bahia state, Brazil
... transmitted drug resistance (TDR) within the drug-naïve population during the 2006-2012 period, compared with previous studies concerning drug-naïve individuals in Bahia (Table ...of ... See full document
8
Conservation patterns of HIV-1 RT connection and RNase H domains: identification of new mutations in NRTI-treated patients.
... created from comparing different HIV-1 polymorphisms present in different subtypes, only subtype B sequences were used for drug-related mutation ...B from treatment- naı¨ve and ... See full document
7
HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naive and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes.
... located in Panama City provided 1,179 HIV-1 pol sequences from drug-resistance genotyping tests performed in participants referred to the ICGES by infectious disease physicians ... See full document
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Prevalence of HIV type 1 drug resistance mutations in treatment-naïve and experienced patients from resource-limited settings with universal access to antiretroviral therapy: a survey in two small Brazilian cities
... collected, DNA was extracted from peripheral blood mononuclear cells (PBMC), and the sequence of a sin- gle fragment of HIV-1 polymerase gene encompassing the whole protease (PR) and reverse ... See full document
7
Excision of HIV-1 proviral DNA by recombinant cell permeable tre-recombinase.
... resulted in the successful introduction of highly active antiretroviral therapy (HAART) into clinical practice for treatment of ...eradicate HIV-1 from the infected organism and, ... See full document
10
Loss from treatment for drug resistant tuberculosis: risk factors and patient outcomes in a community-based program in Khayelitsha, South Africa.
... stopping treatment. These patients had received treatment for a median period of 7 months and most were HIV in- ...poor program performance, with suggestions that such programs are ... See full document
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Resistance mutations and CTL epitopes in archived HIV-1 DNA of patients on antiviral treatment: toward a new concept of vaccine.
... the proviral DNA load was less than 1000 copies/million ...a proviral load above 1000 copies for which we have no explanation other than that their RNA and DNA viral loads may have been high ... See full document
8
Mutations Related to Antiretroviral Resistance Identified by Ultra-Deep Sequencing in HIV-1 Infected Children under Structured Interruptions of HAART.
... I93L mutations in the protease region were found in patient ...I64V in patient No 2. The HIVdb genotypic resistance interpretation algorithm clas- sifies these mutations as ... See full document
11
Overview of genotypic and clinical profiles of human immunodeficiency virus type 1-infected children in Rio de Janeiro, Brazil
... mother-to-child HIV transmission prevention has slowed down pediatric HIV infection in developed countries, large numbers of infants still become infected in developing ...pediatric HIV ... See full document
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HIV-1 SUBTYPES AND MUTATIONS ASSOCIATED TO ANTIRETROVIRAL DRUG RESISTANCE IN HUMAN ISOLATES FROM CENTRAL BRAZIL Daniela Marreco Cerqueira1 , Eduardo Dias Ramalho1 ; Claudiner Pereira Oliveira1 ; Ruiter Roberto Silva2; Miriam Franchini2 ; Maria Sueli Soare
... to HIV-1 drug-resistance and genetic subtypes is important for the control and treatment of HIV-1 ...disease. Drug pressure selects resistant variants that carry mutations ... See full document
6
Likely role of APOBEC3G-mediated G-to-A mutations in HIV-1 evolution and drug resistance.
... members in inhibiting retrovirus infection and mobile element retrotransposition is well ...as HIV- 1 are less well understood. An HIV-1 variant that has been highly G-to-A mutated is unlikely to be ... See full document
9
Sequence analysis of coding DNA fragments of pfcrt and pfmdr-1 genes in Plasmodium falciparum isolates from Odisha, India
... problem in malaria control. The genetic basis of the parasite’s resistance to the antimalarial drug chloroquine (CQ) is well-documented, allowing for the analysis of field isolates of malaria ... See full document
7
Incidence and associated factors of HIV drug resistance in Chinese HIV-infected patients receiving antiretroviral treatment.
... received treatment from 2005 onwards were chronologically contacted for recruiting to the study; detailed subject recruitment procedure has been previously ...receiving HIV antiretroviral therapy ... See full document
6
High-levels of acquired drug resistance in adult patients failing first-line antiretroviral therapy in a rural HIV treatment programme in KwaZulu-Natal, South Africa.
... antiretroviral treatment guidelines recommend routine viral load monitoring to identify virological ...further resistance and progression to immunolo- gical and clinical failure. In this study, the ... See full document
10
Characterization of Partial and Near Full-Length Genomes of HIV-1 Strains Sampled from Recently Infected Individuals in São Paulo, Brazil
... sequences from both MSM (n = 57) and heterosexual individuals (n = 7; 5 males and 2 ...females). In the topological phylogenetic tree of NFLG pure subtype B depicted in Figure 1; various samples are ... See full document
11
Persistence of transmitted HIV-1 drug resistance mutations associated with fitness costs and viral genetic backgrounds.
... challenges in in- fectious diseases ...obstacle in curbing drug resistance is that once it has emerged it often persists even in the ab- sence of drug ...one in the ... See full document
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