[PDF] Top 20 Influence of the Glucocorticoid Receptor on microRNA Profile in Triple-Negative Breast Cancer

... introns. The processing of long pri–miRNA shortens the molecules to 60 to 80 nt long with a secondary hairpin structure, denominated precursor miRNA ...occurs in the nucleus when ... See full document

... bind the inhibitory receptor PD-1 in effector T lymphocytes, inducing nega- tive regulatory pathways that limit the activity of these ...and the secretion of extrinsic ... See full document

... member of the small leucine-rich proteoglycan gene family, exists and functions wholly within the tumor microenvironment to suppress tumorigenesis by directly targeting and antagonizing multiple ... See full document

... Breast cancer is a disease of worldwide relevance because it is the first cause of cancer and the first cause of cancer mortality in women in ... See full document

... mutations in BRCA1/2. Our data support the usefulness of detection of carriers of mutations in genes involved in homologous recombi- nation for appropriate therapy ... See full document

... oncology, the treatment with anticancer drugs is one of the major strategies to control the ...active on cancer cells without causing toxicity in normal ...treatment ... See full document

... focused on the regulations of miRNA on its target genes, but have neglected the abnormal expression and functions of miRNA ...Most of the miRNA genes arise from ... See full document

... total of 2835 operable BC patients at the Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) were retrospectively collected for this ...study. Of these, 292 patients were ... See full document

... with breast carcinoma were recruited for the study at the Hospital de São José, from Centro Hospitalar de Lisboa Central, during 2013 and ...by the Ethical Committees of the NOVA ... See full document

... Triple negative breast cancer (TNBC) is a major global public health ...problem. The lack of targeted therapy and the elevated mortality evidence the need for ... See full document

... with breast carci- noma were recruited for the study at the Hospital de São José, from Centro Hospitalar de Lisboa Central, during 2013 and ...by the Ethics Committees of the ... See full document

... to the AJCC system (American Joint Committee on Cancer) is based on all information available prior the first definitive treatment and includes the findings on ... See full document

... to the results, 68.2% made use of tamoxifen, and of these ...none of the participants was making use of this medication at the time of the ...one of ... See full document

... by the Ethical Committee of the Medical Faculty in ...gated. In study cohort A (n = 207) blood samples were collected from 127 sporadic breast cancer patients and 80 ... See full document

... involvement of glucocorticoid signaling in patterning the zebrafish hypothalamus is a very interesting finding, as the hypothalamus is the initial organizer for the stress ... See full document

... with the highest fre- quency of CNAs in our study and the only one with a signif- icant difference among subtypes, more specifically between TNBC and Luminal ...subtypes. In addition, ... See full document

... censored on the date of the event (death and/or progression) or most recent ...using the log-rank ...analysis, the Cox regression model was used to determine prognostic factors ... See full document

... reported the nuclear staining of beta- catenin was associated with poor outcome of breast cancer patients ...categorize the beta-catenin localization by molecular ...enriched ... See full document

... identification of target genes of specific miRNAs has been essentially carried out by bioinformatics, though the actual identification of target genes depends on the expression ... See full document

... In the end of the human pregnancy, 20mg a day of estradiol are produced by the placental ...and the placenta. The amount of aromatase in the ... See full document