O presente estudo é o primeiro a demonstrar o efeito antidepressivo de Carv em modelo animal de depressão induzida por ECI. Esse efeito é acompanhado da capacidade de reverter sintomas associados à depressão, como déficit cognitivo, diminuição na interação social, anedonia, desequilíbrio na relação pró e antioxidantes e modulação de citocinas pró- inflamatórias.
Os achados desse estudo são promissores, pois apresentam a atividade antidepressiva de Carv em animais, que se mostrou desprovida do efeito sedativo presente na maioria dos fármacos em uso atualmente. Embora os resultados aqui apresentados sejam de grande valor, outros estudos pré-clínicos precisam ser realizados para que Carv seja uma alternativa terapêutica para o tratamento da depressão. Essa investigação deve incluir os mecanismos moleculares que estão envolvidos em sua atividade antidepressiva. Desse modo, estudos posteriores com Carv e possíveis associações são encorajados.
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