Considerações Finais

Frente às questões levenatadas em nossa tese, podemos afirmar que:

Os efeitos benéficos da terapia interdisciplinar para o tratamento da obesidade estão correlacionados com a elevação das adipocinas anti-inflamatórias (adiponectina e IL- 10);

Os efeitos benéficos da terapia interdisciplinar para o tratamento da obesidade estão correlacionados com a redução das citocinas pró-inflamatórias (TNF-α e IL-6), endotoxina e dos depósitos de gordura corporal;

Os efeitos anti-inflamatórios da adiponectina e da IL-10 em adipócitos 3T3-L1 são dissociados;

A ação anti-inflamatória, individual ou conjunta, da adiponectina e IL-10 em adipócitos 3T3-L1, não é mediada por alterações na via de sinalização do TLR-4, mas sim do NF- κB;

A terapia interdicisplinar de longo prazo foi capaz de elevar as adipocinas anti-inflamatória (adiponectina e IL-10), e concomitantemente, promoveu redução do depósito de gordura visceral, IL- 6, TNF-α e endotoxina sérica. Esses eventos direcionaram para melhora do quadro da resistência à ação da insulina nos adolescentes obesos. Adicionalmente, observamos que a concentração sérica de adiponectina pode ser um bom preditor da relação entre gordura visceral e subcutânea.

O estudo in vitro em células adiposas 3T3-L1 confirmou que tais adipocinas anti-inflamatórias tem papel importante na redução da produção de IL-6 e na inibição da ligação do NF-κB com DNA, favorecendo desta maneira redução da via inflamatória. No entanto, tais eventos parece não ser dependetendes dos TLRs, sendo necessários mais estudos para elucidar as vias envolvidas neste processo.

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