Considerando a experiência profissional adquirida por ocasião da realização deste trabalho, experiência esta que veio se somar à minha formação escolar e superior anteriormente adquirida, pretendo continuar desenvolvendo projetos na área de tecnologia farmacêutica no doutorado, dedicando-me, principalmente aos compostos binários e ternários com ciclodextrinas.
Por exemplo:
Verificar a interação dos componentes nos sistemas binários e ternários por Calorimetria Exploratória Diferencial (DSC) e Termogravimetria (TG);
Caracterização dos sistemas binários BNZ:HP-β-CD, BNZ:TEA e BNZ:NMP; e dos sistemas ternários BNZ:β-CD:NMP, BNZ:HP-β-CD:TEA, BNZ:HP-β- CD:NMP por RMN 1H;
Simulação de dinâmica molecular para os sistemas binários BNZ:HP-β-CD, BNZ:TEA e BNZ:NMP; e para os sistemas ternários BNZ:β-CD:NMP, BNZ:HP-β-CD:TEA, BNZ:HP-β-CD:NMP;
Obtenção dos complexos binários e ternários contendo a TEA e NMP por liofilização;
Avaliação da atividade biológica e da biocompatibilidade dos sistemas obtidos in vitro, utilizando cultura de células.
Sendo assim, é minha intenção dar continuidade a este projeto a fim de propor outras formas de aumentar a solubilidade/velocidade de dissolução do benzidazol, contribuindo para a pesquisa e para o desenvolvimento do tratamento da doença de Chagas, a qual é uma doença negligenciada.
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