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In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling.

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Academic year: 2017

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Figure 1. The stability of endogenous Ci is regulated by the UPS in vitro . (A) Lysates extracted from cl-8 cells that were treated with 50 mg/
Figure 2. The stability of endogenous Ci is regulated by the UPS in vivo . (A–C) UPS inhibition protected CiFL from degradation in the wing disc
Table 1. UPS genes identified in the fly genome.
Figure 3. CG13343 negatively regulates CiFL stability and Hh signaling. (A–C) Stabilization of CiFL (A), induction of Hh signaling reporter dpp-lacZ (B) and Col protein (C) abutting the a/p boundary (indicated by the dashed line in A) in wing discs correla
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