• Nenhum resultado encontrado

Increased expression of the dsRNA-activated protein kinase PKR in breast cancer promotes sensitivity to doxorubicin.

N/A
N/A
Protected

Academic year: 2017

Share "Increased expression of the dsRNA-activated protein kinase PKR in breast cancer promotes sensitivity to doxorubicin."

Copied!
12
0
0

Texto

Loading

Imagem

Table 1. Immunohistochemical analysis of PKR expression in normal and breast cancer TMA specimens.
Figure 3. Increased levels of phosphorylated PKR are present in breast cancer cell lines
Figure 4. Breast cancer cell lines with reduced PKR are less sensitive to doxorubicin or H 2 O 2
Figure 5. PKR activity and expression promotes sensitivity to doxorubicin. A. Breast cancer cell lines were treated with either 2.5 mM doxorubicin (DOX) or co-treated with 2.5 mM DOX and increasing concentrations of PKR inhibitor (PKRI) for 48 hours
+3

Referências

Documentos relacionados

Neste sentido, conclui-se que os alunos atribuíram maior importância a motivos intrínsecos do que extrínsecos para se manterem motivados para as aulas de Educação Física,

Thirty women and one man with a diagnosis of carcinoma of the breast and a positive family history of breast cancer, who were receiving treatment at the Breast Cancer

Recomendável: hidropisia (pronuncia-se hidropizía), conforme consta nos dicionários de português. Hidropsia e hidrópsia, apesar de errôneos, são termos amplamente

Our findings indicate that Brb and Dox, alone and in combination, exhibit antiproliferative effects against human breast cancer T47D and MCF7 cell lines, and this

Silencing of FANCF in breast cancer cell lines led to significantly increased DNA damage compared with the cells treated with control shRNA (Figure 3).. Silencing of FANCF induced

We examined PTPN12 mRNA expression in five breast cancer cell lines using semi- quantitative reverse-transcription PCR, and detected PTPN12 protein expression using

To overcome this hurdle for studying the functional role of Vav1 in human breast cancer, we overexpressed Vav1 in two breast cancer cell lines, AU565 and MCF-7, achieving Vav1

In aggressive breast cancer cell lines, a cell population with high ALDH activity as assessed by the Aldefluor assay has been shown to be enriched in tumorigenic stem/progenitor