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ȾɁ «ȾɧɿɩɪɨɩɟɬɪɨɜɫɶɤɚɦɟɞɢɱɧɚɚɤɚɞɟɦɿɹɆɈɁɍɤɪɚʀɧɢ»
ɤɚɮɟɞɪɚɦɟɞɢɱɧɨʀɛɿɨɥɨɝɿʀ, ɮɚɪɦɚɤɨɝɧɨɡɿʀɬɚɛɨɬɚɧɿɤɢ (ɡɚɜ. – ɞ. ɛɿɨɥ. ɧ., ɩɪɨɮ. ȼ.Ɏ. ɒɚɬɨɪɧɚ)
ɜɭɥ. ɋɟɜɚɫɬɨɩɨɥɶɫɶɤɚ, 19, Ⱦɧɿɩɪɨɩɟɬɪɨɜɫɶɤ, 49027 ɍɤɪɚʀɧɚ SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» Department of Medical Biology, Botany and Pharmacognosy
Sevastopols'ka str., 19, Dnipropetrovsk, 49027, Ukraine e-mail: garetsvira@gmail.com
Ʉɥɸɱɨɜɿɫɥɨɜɚɟɦɛɪɿɨɧɚɥɶɧɚɩɟɱɿɧɤɚ, ɚɰɟɬɚɬɫɜɢɧɰɸ, ɰɢɬɪɚɬɫɪɿɛɥɚ, ɰɢɬɪɚɬɡɨɥɨɬɚ
.H\ZRUGV embryonic liver, lead acetate, silver citrate, gold citrate
Ɋɟɮɟɪɚɬ Ɇɨɪɮɨɥɨɝɢɹ ɷɦɛɪɢɨɧɚɥɶɧɨɣ ɩɟɱɟɧɢ ɩɨɞ ɜɥɢɹɧɢɟɦ ɰɢɬɪɚɬɨɜ ɫɟɪɟɛɪɚ ɢ ɡɨɥɨɬɚ ɧɚ ɮɨɧɟ ɫɜɢɧɰɨɜɨɣɢɧɬɨɤɫɢɤɚɰɢɢȽɚɪɟɰȼɂɒɚɬɨɪɧɚɹȼɎȻɟɥɶɫɤɚɹɘɈȼ ɷɤɫɩɟɪɢɦɟɧɬɟɧɚɤɪɵɫɚɯɢɡɭɱɚɥɢ ɦɨɪɮɨɥɨɝɢɱɟɫɤɨɟ ɫɨɫɬɨɹɧɢɟ ɷɦɛɪɢɨɧɚɥɶɧɨɣ ɩɟɱɟɧɢ ɩɨɞɜɥɢɹɧɢɟɦ ɰɢɬɪɚɬɨɜ ɫɟɪɟɛɪɚ ɢ ɡɨɥɨɬɚ ɧɚɮɨɧɟ ɫɜɢɧ -ɰɨɜɨɣ ɢɧɬɨɤɫɢɤɚɰɢɢ. ȼɵɹɜɥɟɧɨ, ɱɬɨ ɡɧɚɱɟɧɢɹ ɝɟɩɚɬɨɮɟɬɚɥɶɧɨɝɨ ɢɧɞɟɤɫɚ ɜ ɝɪɭɩɩɚɯ Pb+Ag ɢ Pb+Au ɢɦɟɥɢ ɞɨɫɬɨɜɟɪɧɵɟ ɨɬɥɢɱɢɹ ɜɫɪɚɜɧɟɧɢɢɫ ɝɪɭɩɩɨɣɫɜɢɧɰɨɜɨɣ ɢɧɬɨɤɫɢɤɚɰɢɢ, ɨɞɧɚɤɨɞɨɫɬɨɜɟɪɧɨɧɟ ɨɬɥɢɱɚɥɢɫɶɨɬ ɤɨɧɬɪɨɥɶɧɵɯɩɨɤɚɡɚɬɟɥɟɣɢɫɨɫɬɚɜɥɹɥɢ 0,086±0,001 ɢ 0,083±0,001 ɫɨɨɬɜɟɬɫɬɜɟɧɧɨ. ȼɟɥɢɱɢɧɚɨɬɧɨɫɢɬɟɥɶɧɨɣ ɩɥɨɳɚɞɢ ɤɪɨɜɟɧɨɫɧɵɯ ɫɨɫɭɞɨɜ ɜ ɝɪɭɩɩɚɯ Pb+Ag ɢ Pb+Au ɫɨɫɬɚɜɥɹɥɚ 13,08±0,53% ɢ 16,83±0,53% ɫɨɨɬ -ɜɟɬɫɬɜɟɧɧɨ, ɱɬɨ ɬɚɤɠɟ ɧɟ ɢɦɟɥɨ ɞɨɫɬɨɜɟɪɧɨɣ ɪɚɡɧɢɰɵ ɩɨ ɫɪɚɜɧɟɧɢɸ ɫ ɤɨɧɬɪɨɥɶɧɨɣ ɝɪɭɩɩɨɣ, ɨɞɧɚɤɨ ɨɬɥɢɱɚɥɨɫɶ ɨɬ ɜɟɥɢɱɢɧɵ ɩɨɤɚɡɚɬɟɥɟɣ ɝɪɭɩɩɵ ɫɜɢɧɰɨɜɨɣ ɢɧɬɨɤɫɢɤɚɰɢɢ. ɉɨɞ ɜɥɢɹɧɢɟɦ ɰɢɬɪɚɬɚ ɫɟɪɟɛɪɚ ɧɚ ɮɨɧɟ ɫɜɢɧɰɨɜɨɣ ɢɧɬɨɤɫɢɤɚɰɢɢ ɡɧɚɱɟɧɢɟ ɨɬɧɨɫɢɬɟɥɶɧɨɣ ɩɥɨɳɚɞɢ ɝɟɦɨɩɨɷɬɢɱɟɫɤɢɯ ɤɥɟɬɨɤ ɫɨɫɬɚɜɥɹɥɨ 52,5±0,95%, ɱɬɨ ɫɜɢɞɟɬɟɥɶɫɬɜɭɟɬ ɨ ɦɨɞɢɮɢɰɢɪɭɸɳɟɦ ɞɟɣɫɬɜɢɢ ɫɟɪɟɛɪɚ ɧɚ ɩɪɨɰɟɫɫɵ ɝɟɦɨɩɨɷɡɚ ɜ ɷɦɛɪɢɨ -ɧɚɥɶɧɨɣ ɩɟɱɟɧɢ. Ɍɚɤɢɦ ɨɛɪɚɡɨɦ, ɜɜɟɞɟɧɢɟ ɰɢɬɪɚɬɨɜ ɫɟɪɟɛɪɚ ɢ ɡɨɥɨɬɚ ɩɪɟɞɭɩɪɟɠɞɚɟɬ ɧɟɝɚɬɢɜɧɨɟ ɜɥɢɹɧɢɟ ɫɜɢɧɰɚ ɧɚ ɦɨɪɮɨɦɟɬɪɢɱɟɫɤɢɟ ɩɨɤɚɡɚɬɟɥɢ ɷɦɛɪɢɨɧɚɥɶɧɨɣ ɩɟɱɟɧɢ, ɨɬɧɨɫɢɬɟɥɶɧɭɸ ɩɥɨɳɚɞɶ ɤɪɨɜɟɧɨɫɧɵɯ ɫɨɫɭɞɨɜ ɢ ɝɟɦɨɩɨɷɬɢɱɟɫɤɢɯ ɤɥɟɬɨɤ. ɉɨɥɭɱɟɧɧɵɟ ɜ ɯɨɞɟ ɷɤɫɩɟɪɢɦɟɧɬɚ ɞɚɧɧɵɟ ɫɜɢɞɟɬɟɥɶɫɬɜɭɸɬ ɨ ɩɪɨɬɟɤ -ɬɨɪɧɨɦ ɞɟɣɫɬɜɢɢɫɟɪɟɛɪɚɢɡɨɥɨɬɚɩɪɢɫɜɢɧɰɨɜɨɣɢɧɬɨɤɫɢɤɚɰɢɢɜɩɟɪɢɨɞɝɟɩɚɬɨɝɟɧɟɡɚ.
$EVWUDFW0RUSKRORJ\RIHPEU\RQLFOLYHUXQGHUWKHLQIOXHQFHRIVLOYHUDQGJROGFLWUDWHVRQDEDFNJURXQGRIOHDG LQWR[LFDWLRQ+DUHWV9,6KDWRUQD9)%HOVND,X2Morphological state of embryonic liver under the influence of silver and gold citrates on a background of lead intoxication was studied. We found that values of the hepatofetal index in the groups Pb+Ag and Pb+Au had significant differences as compared to the group exposed to lead intoxication, but did not differ significantly from the control group and made up 0,086±0,001 and 0,083±0,001, respectively. Value of the relative area of blood vessels in groups Pb+Ag and Pb+Au was 13.08±0.53% and 16.83±0.53%, respectively, which had no significant difference as compared to control group, but differed from the value of lead intoxication group. Under the influence of silver citrate on a background of lead intoxication the relative area ofhematopoietic cells was 52,5±0,95%; this indicates to modification action of silver on haematopoiesis. Thus, injection of silver and gold citrates prevents negative effect of lead on morphometric parameters of embryonic liver, relative area of blood vessels and hematopoietic cells. Experiment results showed protective effect of silver and gold citrates on a background of lead intoxication during hepatogenesis.
ɋɜɢɧɟɰɶ ± ɩɪɢɪɨɞɧɢɣ ɬɨɤɫɢɱɧɢɣ ɟɥɟɦɟɧɬ ɹɤɢɣ ɽ ɱɚɫɬɢɧɨɸ ɡɟɦɧɨʀ ɤɨɪɢ ȼɢɤɨɪɢɫɬɚɧɧɹ ɰɶɨɝɨ ɦɟɬɚɥɭ ɜ ɩɪɨɦɢɫɥɨɜɨɫɬɿ ɩɪɢɡɜɟɥɨ ɞɨ ɲɢ ɪɨɤɨɦɚɫɲɬɚɛɧɨɝɨ ɡɚɛɪɭɞɧɟɧɧɹ ɧɚɜɤɨɥɢɲɧɶɨɝɨ ɫɟɪɟɞɨɜɢɳɚɿɩɨɪɭɲɟɧɶɝɪɨɦɚɞɫɶɤɨɝɨɡɞɨɪɨɜɹɭ ɛɚɝɚɬɶɨɯ ɤɪɚʀɧɚɯ ɫɜɿɬɭ ɋɜɢɧɟɰɶ ɯɚɪɚɤɬɟɪɢ ɡɭɽɬɶɫɹɩɨɥɿɬɪɨɩɧɿɫɬɸɞɿʀɧɚɨɪɝɚɧɿɡɦɥɸɞɢɧɢɬɚ ɩɪɢɡɜɨɞɢɬɶ ɞɨ ɜɢɧɢɤɧɟɧɧɹ ɛɚɝɚɬɶɨɯ ɦɟɬɚɛɨɥɿɱ ɧɢɯɪɨɡɥɚɞɿɜ>@ɋɨɥɿɩɥɸɦɛɭɦɭɧɚɤɨɩɢɱɭɸɬɶɫɹ ɜ ɤɿɫɬɤɚɯ ɜɢɤɥɢɤɚɸɬɶ ʀɯ ɩɨɲɤɨɞɠɟɧɧɹ ɬɚ ɪɨɡɜɢɬɨɤ ɨɫɬɟɨɩɨɪɨɡɭ >@ ȼɚɝɿɬɧɿ ɠɿɧɤɢ ɣ ɞɿɬɢ
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ɞɟɡɨɪɝɚɧɿɡɚɰɿɸ ɩɚɪɟɧɯɿɦɢ ɣ ɫɭɞɢɧɧɨɝɨ ɤɨɦɩɨ ɧɟɧɬɚ ɩɟɱɿɧɤɢ > @ ɇɚ ɫɶɨɝɨɞɧɿɲɧɿɣ ɞɟɧɶ ɜɿɞɨɦɢɣ ɪɹɞ ɦɿɤɪɨɟɥɟɦɟɧɬɿɜ ɡ ɛɿɨɚɧɬɚɝɨɧɿɫɬɢɱ ɧɢɦɢɜɥɚɫɬɢɜɨɫɬɹɦɢɩɨɜɿɞɧɨɲɟɧɧɸɞɨɫɜɢɧɰɸ Ⱦɨɫɥɿɞɠɟɧɧɹ ɫɜɿɞɱɚɬɶ ɳɨ ɰɢɧɤ ɜɫɬɭɩɚɸɱɢ ɜ ɤɨɧɤɭɪɟɧɬɧɭ ɜɡɚɽɦɨɞɿɸ ɡɿ ɫɜɢɧɰɟɦ ɦɿɧɿɦɿɡɭɽ ɣɨɝɨ ɲɤɿɞɥɢɜɢɣ ɜɩɥɢɜ ɜɟɞɟ ɞɨ ɡɧɢɠɟɧɧɹ ɩɨ ɤɚɡɧɢɤɿɜ ɟɦɛɪɿɨɥɟɬɚɥɶɧɨɫɬɿ ɬɚ ɡɛɿɥɶɲɟɧɧɹ ɤɿɥɶ ɤɨɫɬɿ ɠɢɜɢɯ ɩɥɨɞɿɜ > @ ɒɢɪɨɤɨɜɿɞɨɦɢɦ ɦɿɤɪɨɟɥɟɦɟɧɬɨɦ ɩɪɨɬɢɞɿɸɱɢɦ ɫɜɢɧɰɸ ɽ ɫɟɥɟɧ ɹɤɢɣ ɡɦɟɧɲɭɽ ɫɜɢɧɟɰɶɿɧɞɭɤɨɜɚɧɢɣ ɨɤɫɢɞɚɬɢɜ ɧɢɣɫɬɪɟɫ>@
ɋɪɿɛɥɨ ɬɚ ɡɨɥɨɬɨ ɩɨɫɿɞɚɸɬɶ ɨɫɨɛɥɢɜɟ ɦɿɫɰɟ ɫɟɪɟɞ ɭɫɶɨɝɨ ɪɿɡɧɨɦɚɧɿɬɬɹ ɦɿɤɪɨɟɥɟɦɟɧɬɿɜ ɋɪɿɛɥɨɦɚɽɲɢɪɨɤɢɣɫɩɟɤɬɪɚɧɬɢɛɚɤɬɟɪɿɚɥɶɧɢɯɿ ɚɧɬɢɦɿɤɨɬɢɱɧɢɯɟɮɟɤɬɿɜɬɚɱɢɧɢɬɶɫɬɢɦɭɥɸɸɱɢɣ ɟɮɟɤɬ ɧɚ ɤɪɨɜɨɬɜɨɪɧɿ ɨɪɝɚɧɢ > @ Ɂɨɥɨɬɨ ɜɢɤɨɪɢɫɬɨɜɭɽɬɶɫɹ ɜ ɬɟɪɚɩɿʀ ɨɧɤɨɥɨɝɿɱɧɢɯ ɡɚɯɜɨɪɸɜɚɧɶ ɚ ɬɚɤɨɠ ɡ ɦɟɬɨɸ ɞɿɚɝɧɨɫɬɢɤɢ ɬɚ ɥɿɤɭɜɚɧɧɹ ɪɟɜɦɚɬɢɱɧɢɯ ɯɜɨɪɨɛ >@ ɉɨɩɟɪɟɞɧɿ ɞɨɫɥɿɞɠɟɧɧɹ ɜɢɹɜɢɥɢ ɦɨɞɢɮɿɤɭɸɱɢɣ ɟɮɟɤɬ ɫɪɿɛɥɚ ɬɚ ɡɨɥɨɬɚ ɧɚ ɬɥɿ ɫɜɢɧɰɟɜɨʀ ɿɧɬɨɤɫɢɤɚɰɿʀ ɩɪɨɬɹɝɨɦ ɟɦɛɪɿɨɧɚɥɶɧɨɝɨ ɩɟɪɿɨɞɭ >@ ɉɪɨɬɟ ɨɪɝɚɧɨɝɟɧɟɡ ɩɟɱɿɧɤɢ ɩɿɞ ɫɭɦɿɫɧɢɦ ɜɩɥɢɜɨɦ ɰɢɬ ɪɚɬɿɜɫɪɿɛɥɚɿɡɨɥɨɬɚɧɚɬɥɿɫɜɢɧɰɟɜɨʀɿɧɬɨɤɫɢɤɚɰɿʀ ɜɢɜɱɟɧɢɣɧɟɞɨɫɬɚɬɧɶɨ
Ɍɨɦɭ ɦɟɬɨɸ ɧɚɲɨɝɨ ɞɨɫɥɿɞɠɟɧɧɹ ɛɭɥɨ ɜɢ ɹɜɥɟɧɧɹ ɦɨɞɢɮɿɤɭɸɱɢɯ ɟɮɟɤɬɿɜ ɰɢɬɪɚɬɿɜ ɫɪɿɛɥɚ ɬɚ ɡɨɥɨɬɚ ɧɚ ɦɨɪɮɨɥɨɝɿɱɧɢɣ ɫɬɚɧ ɩɟɱɿɧɤɢ ɟɦɛɪɿɨɧɿɜ ɳɭɪɿɜ ɞɧɹ ɩɪɟɧɚɬɚɥɶɧɨɝɨ ɪɨɡɜɢɬɤɭ ɧɚɬɥɿɫɜɢɧɰɟɜɨʀɿɧɬɨɤɫɢɤɚɰɿʀ
ɆȺɌȿɊȱȺɅɂɌȺɆȿɌɈȾɂȾɈɋɅȱȾɀȿɇɖ ȿɤɫɩɟɪɢɦɟɧɬɚɥɶɧɚ ɱɚɫɬɢɧɚ ɪɨɛɨɬɢ ɜɢɤɨɧɚɧɚ ɧɚ ɛɿɥɢɯ ɫɬɚɬɟɜɨɡɪɿɥɢɯ ɳɭɪɚɯɫɚɦɢɰɹɯ ɥɿɧɿʀ ȼɿɫɬɚɪ ɜɚɝɨɸ ɝ ɭ ɜɿɰɿ ɞɧɿɜ Ⱦɨ ɫɥɿɞɠɟɧɧɹɧɚɬɜɚɪɢɧɚɯɩɪɨɜɨɞɢɥɢɜɿɞɩɨɜɿɞɧɨɞɨ ©Ɂɚɝɚɥɶɧɢɯɟɬɢɱɧɢɯɩɪɢɧɰɢɩɿɜɟɤɫɩɟɪɢɦɟɧɬɿɜɧɚ ɬɜɚɪɢɧɚɯª Ʉɢʀɜ ɹɤɿ ɭɡɝɨɞɠɭɸɬɶɫɹ ɡ ȯɜɪɨɩɟɣɫɶɤɨɸ ɤɨɧɜɟɧɰɿɽɸ ɩɪɨ ɡɚɯɢɫɬ ɟɤɫɩɟɪɢ ɦɟɧɬɚɥɶɧɢɯɬɜɚɪɢɧɋɬɪɚɫɛɭɪɝ
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Ɂɚɝɚɥɶɧɨɜɿɞɨɦɨ ɳɨ ɭ ɜɿɞɩɨɜɿɞɶ ɧɚ ɞɿɸ ɫɜɢɧɰɸ ɜ ɨɪɝɚɧɚɯ ɜɿɞɛɭɜɚɽɬɶɫɹ ɪɨɡɪɨɫɬɚɧɧɹ ɫɩɨɥɭɱɧɨʀ ɬɤɚɧɢɧɢ ɇɚɦɢ ɜɢɹɜɥɟɧɨ ɳɨ ɜ ɝɪɭɩɿ ɫɜɢɧɰɟɜɨʀ ɿɧɬɨɤɫɢɤɚɰɿʀ ɜɟɥɢɱɢɧɚ ȽɎȱ ɫɬɚɧɨɜɢɥɚ ɳɨ ɧɚ ɛɿɥɶɲɟ ɩɨɪɿɜɧɹɧɨ ɡ ɤɨɧɬɪɨɥɶɧɨɸ ɝɪɭɩɨɸ S Ɇɚɫɚ ɩɟɱɿɧɤɢ ɡɛɿɥɶɲɭɜɚɥɚɫɹɡɚɪɚɯɭɧɨɤɪɨɡɪɨɫɬɚɧɧɹɫɩɨɥɭɱɧɨʀ ɬɤɚɧɢɧɢɭɜɿɞɩɨɜɿɞɶɧɚɜɩɥɢɜɬɨɤɫɢɱɧɨɝɨɚɝɟɧɬɭ ɍ ɝɪɭɩɿ 3E$J ɜɟɥɢɱɢɧɚ ȽɎȱ ɩɪɚɤɬɢɱɧɨ ɜɿɞɩɨɜɿɞɚɥɚ ɡɧɚɱɟɧɧɹɦ ɝɪɭɩɢ ɤɨɧɬɪɨɥɶɧɢɯ ɬɜɚ ɪɢɧ ɿ ɫɬɚɧɨɜɢɥɚ ɳɨ ɞɨɫɬɨɜɿɪɧɨ ɦɟɧɲɟ ɧɚ ɩɨɪɿɜɧɹɧɨ ɡ ɝɪɭɩɨɸ 3E ɿ ɧɚ ɛɿɥɶɲɟɰɶɨɝɨɩɨɤɚɡɧɢɤɚɭɬɜɚɪɢɧɝɪɭɩɢ.ɍɝɪɭ ɩɿ 3E$X ɡɧɚɱɟɧɧɹ ȽɎȱ ɫɬɚɧɨɜɢɥɢ ɳɨɞɨɫɬɨɜɿɪɧɨɦɟɧɲɟɧɚɩɨɪɿɜɧɹɧɨɡɝɪɭɩɨɸ
3E ɿ ɧɚ ɦɟɧɲɟ ɰɶɨɝɨ ɩɨɤɚɡɧɢɤɚ ɭ ɬɜɚɪɢɧ ɝɪɭɩɢ . Ɍɨɛɬɨ ɩɪɢ ɜɜɟɞɟɧɧɿ ɰɢɬɪɚɬɿɜ ɫɪɿɛɥɚ ɬɚ ɡɨɥɨɬɚɧɚɬɥɿɫɜɢɧɰɟɜɨɝɨɜɩɥɢɜɭɫɩɨɫɬɟɪɿɝɚɽɬɶɫɹ ɜɿɞɧɨɜɥɟɧɧɹ ɦɨɪɮɨɦɟɬɪɢɱɧɢɯ ɩɨɤɚɡɧɢɤɿɜ ɩɟɱɿɧ ɤɢɞɨɪɿɜɧɹɡɧɚɱɟɧɶɤɨɧɬɪɨɥɶɧɨʀɝɪɭɩɢ
ȼɿɞɧɨɫɧɚ ɩɥɨɳɚ ɤɪɨɜɨɧɨɫɧɢɯ ɫɭɞɢɧ ȼɉɋ ɟɦɛɪɿɨɧɚɥɶɧɨʀ ɩɟɱɿɧɤɢ ɭ ɝɪɭɩɿ 3E ɫɬɚɧɨɜɢɥɚ ɳɨ ɧɚ ɦɟɧɲɟ ɜɿɞ ɝɪɭɩɢ . Sɇɚɧɚɲɭɞɭɦɤɭɰɟɫɜɿɞɱɢɬɶɩɪɨɡɚɬɪɢɦ ɤɭ ɚɧɝɿɨɝɟɧɟɡɭ ɩɿɞ ɜɩɥɢɜɨɦ ɚɰɟɬɚɬɭ ɫɜɢɧɰɸ ɍ ɝɪɭɩɿ 3E$J ɜɟɥɢɱɢɧɚ ȼɉɋ ɫɬɚɧɨɜɢɥɚ ɳɨ ɧɟɫɭɬɬɽɜɨ ɦɟɧɲɟ ɜɿɞ ɝɪɭɩɢ Ʉ ɩɪɨɬɟ ɛɿɥɶɲɟ ɧɚ ɩɨɪɿɜɧɹɧɨ ɡ ɝɪɭɩɨɸ 3E S ɍ ɝɪɭɩɿ 3E$X ɜɟɥɢɱɢɧɚ ȼɉɋ ɫɬɚɧɨ ɜɢɥɚ ɳɨ ɛɿɥɶɲɟ ɧɚ ɜɿɞ ɤɨɧɬɪɨɥɶɧɢɯ ɡɧɚɱɟɧɶ ɿ ɡɧɚɱɧɨ ɛɿɥɶɲɟ ɧɚ ɩɨɪɿɜɧɹɧɨ ɡ ɝɪɭɩɨɸ 3E S Ɉɬɪɢɦɚɧɿ ɞɚɧɿ ɞɚɸɬɶɩɿɞɫɬɚɜɭɩɪɢɩɭɫɬɢɬɢɳɨɰɢɬɪɚɬɢɫɪɿɛɥɚɬɚ ɡɨɥɨɬɚɧɚɬɥɿɫɜɢɧɰɟɜɨʀɿɧɬɨɤɫɢɤɚɰɿʀɩɪɨɹɜɥɹɸɬɶ ɦɨɞɢɮɿɤɭɸɱɿ ɜɥɚɫɬɢɜɨɫɬɿ ɩɪɢ ɟɦɛɪɿɨɧɚɥɶɧɨɦɭ ɪɨɡɜɢɬɤɭɩɟɱɿɧɤɢɪɢɫ
. 3E 3E$J 3E$X
ȼɉɋ ȼɉȽ
ɉ ɪ ɢ ɦ ɿ ɬ ɤ ɢ ȼɉɋ ɜɿɞɧɨɫɧɚ ɩɥɨɳɚ ɤɪɨɜɨɧɨɫɧɢɯ ɫɭɞɢɧ ȼɉȽ ɜɿɞɧɨɫɧɚ ɩɥɨɳɚ ɝɟɦɨɩɨɟɬɢɱɧɢɯ ɤɥɿɬɢɧ ɞɨɫɬɨɜɿɪɧɚ ɜɿɞɦɿɧɧɿɫɬɶ ɜɿɞ
ɬɜɚɪɢɧɝɪɭɩɢɄSɞɨɫɬɨɜɿɪɧɚɜɿɞɦɿɧɧɿɫɬɶɜɿɞɬɜɚɪɢɧɝɪɭɩɢ3ES
ȼɿɞɧɨɫɧɚɩɥɨɳɚɤɪɨɜɨɧɨɫɧɢɯɫɭɞɢɧɬɚɝɟɦɨɩɨɟɬɢɱɧɢɯɤɥɿɬɢɧ ɟɦɛɪɿɨɧɚɥɶɧɨʀɩɟɱɿɧɤɢɳɭɪɿɜɧɚɞɟɧɶɪɨɡɜɢɬɤɭ
ȼ ɟɦɛɪɿɨɧɚɥɶɧɢɣ ɩɟɪɿɨɞ ɪɨɡɜɢɬɤɭ ɳɭɪɿɜ ɩɟɱɿɧɤɚɛɟɪɟɧɚɫɟɛɟɮɭɧɤɰɿɸɤɪɨɜɨɬɜɨɪɟɧɧɹɹɤɚ ɞɨɫɹɝɚɽɦɚɤɫɢɦɭɦɭɧɚɞɟɧɶɩɪɟɧɚɬɚɥɶɧɨɝɨ ɨɧɬɨɝɟɧɟɡɭɌɨɦɭɨɫɧɨɜɧɢɦɤɨɦɩɨɧɟɧɬɨɦɩɚɪɟɧ ɯɿɦɢɩɟɱɿɧɤɢɧɚɞɟɧɶɽɝɟɦɨɩɨɟɬɢɱɧɿɤɥɿɬɢɧɢ ɉɿɞ ɜɩɥɢɜɨɦ ɚɰɟɬɚɬɭ ɫɜɢɧɰɸ ɜɿɞɧɨɫɧɚ ɩɥɨɳɚ ɝɟɦɨɩɨɟɬɢɱɧɢɯ ɤɥɿɬɢɧ ȼɉȽ ɫɬɚɧɨɜɢɥɚ
ɌȿɈɊȿɌɂɑɇȺ
ɆȿȾɂɐɂɇȺ
ɫɜɢɧɰɟɜɨʀɿɧɬɨɤɫɢɤɚɰɿʀɍɝɪɭɩɿ3E$Xɜɟɥɢɱɢɧɚ ȼɉȽ ɫɬɚɧɨɜɢɥɚ ɳɨ ɧɚ ɦɟɧɲɟ ɩɨɪɿɜɧɹɧɨ ɡ ɝɪɭɩɨɸ Ʉ S ɩɪɨɬɟ ɧɚ ɛɿɥɶɲɟɜɿɞɡɧɚɱɟɧɶɝɪɭɩɢ3Eɪɢɫ
ȼɂɋɇɈȼɄɂ
ɐɢɬɪɚɬɢ ɫɪɿɛɥɚ ɬɚ ɡɨɥɨɬɚ ɧɚ ɬɥɿ ɫɜɢɧɰɟɜɨʀ ɿɧɬɨɤɫɢɤɚɰɿʀ ɜ ɩɟɪɿɨɞ ɝɟɩɚɬɨɝɟɧɟɡɭ ɦɚɸɬɶ ɦɨɞɢ
ɮɿɤɭɸɱɭ ɞɿɸ ɩɪɨ ɳɨ ɫɜɿɞɱɢɬɶ ɜɿɞɧɨɜɥɟɧɧɹ ɦɨɪɮɨɦɟɬɪɢɱɧɢɯ ɬɚ ɚɧɝɿɨɝɟɧɟɬɢɱɧɢɯ ɩɨɤɚɡɧɢɤɿɜ ɞɨɪɿɜɧɹɤɨɧɬɪɨɥɶɧɢɯɡɧɚɱɟɧɶ
ȼɜɟɞɟɧɧɹ ɰɢɬɪɚɬɭ ɫɪɿɛɥɚ ɜ ɭɦɨɜɚɯ ɫɜɢɧ ɰɟɜɨʀ ɿɧɬɨɤɫɢɤɚɰɿʀ ɡɚɩɨɛɿɝɚɽ ɡɚɬɪɢɦɰɿ ɩɪɨɰɟɫɿɜ ɝɟɦɨɩɨɟɡɭɜɟɦɛɪɿɨɧɚɥɶɧɿɣɩɟɱɿɧɰɿ
ɋ
ɋɉ
ɉɂ
ɂɋ
ɋɈ
Ɉ
Ʉ
Ʉ
Ʌ
Ʌȱ
ȱɌ
Ɍȿ
ȿɊ
ɊȺ
ȺɌ
Ɍɍ
ɍɊ
Ɋɂ
ɂ
ȺɜɬɚɧɞɢɥɨɜȽȽɆɟɞɢɰɢɧɫɤɚɹɦɨɪɮɨɦɟɬɪɢɹ ȽȽȺɜɬɚɧɞɢɥɨɜ±Ɇɨɫɤɜɚ±ɫ
Ȼɟɥɟɰɤɚɹ ɗɇ Ƚɢɝɢɟɧɢɱɟɫɤɢɟ ɚɫɩɟɤɬɵ ɨɫɬɟɨ ɬɪɨɩɧɨɫɬɢ ɫɜɢɧɰɚ ɤɚɤ ɮɚɤɬɨɪɚ ɪɢɫɤɚ ɤɚɥɶɰɢɣɞɟ ɮɢɰɢɬɧɨɣɩɚɬɨɥɨɝɢɢɭɱɟɥɨɜɟɤɚɨɛɡɨɪɥɢɬɟɪɚɬɭɪɵ ɗɇȻɟɥɟɰɤɚɹɇɆɈɧɭɥɈȼȻɟɡɭɛɆɟɞɢɱɧɿɩɟɪ ɫɩɟɤɬɢɜɢ±±Ɍ;,;ʋ±ɋ
Ȼɿɨɩɪɨɬɟɤɬɪɨɧɚɞɿɹɰɢɧɤɭɜɦɚɤɪɨɿɧɚɧɨɚɤɜɚ ɯɟɥɚɬɧɿɣ ɮɨɪɦɿ ɧɚ ɟɦɛɪɿɨɝɟɧɟɡ ɳɭɪɿɜ ɡɚ ɭɦɨɜɢ ɫɜɢɧ ɰɟɜɨʀ ɿɧɬɨɤɫɢɤɚɰɿʀ ȿɆȻɿɥɟɰɶɤɚ ȱɋɑɟɤɦɚɧ ɇɆɈɧɭɥ>ɬɚɿɧ@Ɇɟɞɢɱɧɿɩɟɪɫɩɟɤɬɢɜɢ±± Ɍ;9,,,ʋ±ɋ±
Ⱦɨɜɝɚɥɶ Ƚȼ Ɇɨɪɮɨɥɨɝɿɱɧɿ ɡɦɿɧɢ ɜ ɪɨɡɜɢɬɤɭ ɩɟɱɿɧɤɢɳɭɪɿɜɩɪɢɜɩɥɢɜɿɚɰɟɬɚɬɭɫɜɢɧɰɸɬɚɡɚɭɦɨɜ ɤɨɪɟɤɰɿʀ ɜ ɩɪɟɧɚɬɚɥɶɧɨɦɭ ɩɟɪɿɨɞɿ Ƚȼ Ⱦɨɜɝɚɥɶ ɍɤɪɦɨɪɮɨɥɚɥɶɦɚɧɚɯ±±Ɍʋ±ɋ
ȿɤɫɩɟɪɢɦɟɧɬɚɥɶɧɟ ɞɨɫɥɿɞɠɟɧɧɹ ɦɨɞɢɮɿɤɭɸ ɱɨɝɨ ɜɩɥɢɜɭ ɧɚɧɨɚɤɜɚɯɟɥɚɬɭ ɰɢɬɪɚɬɭ ɡɨɥɨɬɚ ɧɚ ɟɦɛɪɿɨɬɨɤɫɢɱɧɿɫɬɶɚɰɟɬɚɬɭɫɜɢɧɰɸɭɳɭɪɿɜȼɎɒɚ ɬɨɪɧɚ ȼȱ Ƚɚɪɟɰɶ ȿɆ Ȼɿɥɟɰɶɤɚ >ɬɚ ɿɧ@ Ɇɟɞɢɱɧɿ ɩɟɪɫɩɟɤɬɢɜɢ±±Ɍ;,;ʋ±ɋ
ɉɨɬɨɰɶɤɚɈɘ ȽɨɪɛɭɧɨɜȺɈ Ɍɜɟɪɞɨ ɯɥɿɛȱȼ>ɬɚɿɧ@ɋɩɨɫɿɛɜɢɦɿɪɸɜɚɧɧɹɦɿɤɪɨɫɤɨɩɿɱɧɢɯ ɫɬɪɭɤɬɭɪ8$ɉɚɬɟɧɬ8$
ɊɨɦɚɧɟɧɤɨɈȺȱɦɭɧɨɝɿɫɬɨɯɿɦɿɱɧɟɞɨɫɥɿɞɠɟɧ ɧɹ ɩɟɱɿɧɤɢ ɳɭɪɿɜ ɜ ɩɿɡɧɶɨɦɭ ɩɪɟɧɚɬɚɥɶɧɨɦɭ ɩɟɪɿɨɞɿ ɩɿɞ ɜɩɥɢɜɨɦ ɚɰɟɬɚɬɭ ɫɜɢɧɰɸ ɬɚ ɡɚ ɭɦɨɜ ɤɨɪɟɤɰɿʀ ɈȺɊɨɦɚɧɟɧɤɨȽȼȾɨɜɝɚɥɶɆȺȾɨɜɝɚɥɶȼɿɫɧɢɤ ɩɪɨɛɥɟɦ ɛɿɨɥɨɝɿʀ ɿ ɦɟɞɢɰɢɧɢ ± ± ȼɢɩ ± ɋ
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Ʌɶɜɿɜɫɶɤɢɣɧɚɰɿɨɧɚɥɶɧɢɣɦɟɞɢɱɧɢɣɭɧɿɜɟɪɫɢɬɟɬɿɦ. ȾɚɧɢɥɚȽɚɥɢɰɶɤɨɝɨ
ɤɚɮɟɞɪɚɧɨɪɦɚɥɶɧɨʀɮɿɡɿɨɥɨɝɿʀ
(ɜ.ɨ. ɡɚɜ. – ɤ. ɦɟɞ. ɧ., ɞɨɰ. Ɉ.Ƚ. Ɇɢɫɚɤɨɜɟɰɶ) ɜɭɥ. ɉɟɤɚɪɫɶɤɚ, 69, Ʌɶɜɿɜ, 79010, ɍɤɪɚʀɧɚ Danylo Halytsky Lviv National Medical University Department of physiology
Pekarska str., 52, Lviv, 79010, Ukraine e-mail: lnmu.fedorenkov.i@gmail.com
Ʉɥɸɱɨɜɿɫɥɨɜɚɿɦɦɨɛɿɥɿɡɚɰɿɣɧɢɣɫɬɪɟɫ, ɚɤɬɢɜɧɢɣɿɩɚɫɢɜɧɢɣɬɢɩɩɨɜɟɞɿɧɤɢ, ɛɿɨɯɿɦɿɱɧɿɩɨɤɚɡɧɢɤɢ, ɚɞɚɩɬɚɰɿɣɧɿ ɩɪɨɰɟɫɢ
