Correction: Mutation of the Diamond-Blackfan Anemia Gene Rps7 in Mouse Results in Morphological and Neuroanatomical Phenotypes.

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CORRECTION

Correction: Mutation of the

Diamond-Blackfan Anemia Gene

Rps7

in Mouse Results

in Morphological and Neuroanatomical

Phenotypes

Dawn E. Watkins-Chow, Joanna Cooke, Ruth Pidsley, Andrew Edwards, Rebecca Slotkin,

Karen E. Leeds, Raymond Mullen, Laura L. Baxter, Thomas G. Campbell, Marion C. Salzer,

Laura Biondini, Gretchen Gibney, Françoise Phan Dinh Tuy, Jamel Chelly, H.

Douglas Morris, Johannes Riegler, Mark F. Lythgoe, Ruth M. Arkell, Fabrizio Loreni,

Jonathan Flint, William J. Pavan, David A. Keays

The top left image of

Fig 2B

is incorrect. The authors have provided a corrected version of

Fig 2

here.

PLOS Genetics | DOI:10.1371/journal.pgen.1005682 November 19, 2015 1 / 3

OPEN ACCESS

Citation:Watkins-Chow DE, Cooke J, Pidsley R, Edwards A, Slotkin R, Leeds KE, et al. (2015) Correction: Mutation of the Diamond-Blackfan Anemia GeneRps7in Mouse Results in Morphological and Neuroanatomical Phenotypes. PLoS Genet 11(11): e1005682. doi:10.1371/journal. pgen.1005682

Published:November 19, 2015

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Fig 2.Rps7Mtu

shows reduced function in ribosomal precursor processing.(A) Western blot showing similar levels of expression for N- and C-terminal FLAG-tagged wild-type RPS7 (WT-N and WT-C, respectively) and RPS7Mtu_{(M-N and M-C, respectively) proteins in HEK-293 cells. The RPS7-specific band} is indicated by*, and NPT2 (arrowhead) expression is shown as a control. (B) Subcellular localization of N-and C-terminal FLAG-tagged RPS7 proteins. Wild-type RPS7 N-and RPS7Mtu_{both localize to speckles in the}

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Reference

1. Watkins-Chow DE, Cooke J, Pidsley R, Edwards A, Slotkin R, Leeds KE, et al. (2013) Mutation of the Diamond-Blackfan Anemia GeneRps7in Mouse Results in Morphological and Neuroanatomical Phe-notypes. PLoS Genet 9(1): e1003094. doi:10.1371/journal.pgen.1003094PMID:23382688

nucleus and are observed throughout the cytoplasm. Scale bar = 10μm. All panels are at the same magnification. (C) Representative Northern blot analysis of liver and brain RNA from wild-type (WT) and

Rps7Mtu/+ (M) mice detecting various rRNA precursors using a probe within the internal transcribed spacer (ITS1). The 30S and 21S rRNA precursors are indicated. (D) Quantitation of the signals of Northern experiments reported as the ratio between 30S and 21S rRNA precursors was significantly different between

Rps7+/+ and Rps7Mtu/+ (*indicates p<_{0.01). The average of the values is reported in the bar graphs with S.} E.M.

doi:10.1371/journal.pgen.1005682.g001