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: 09131146910
E-mail: maryam_karami@yahoo.com
Comparison of the Concentration and Longevity of the Salivary Fluoride after Fluoride Therapy with the Varnish and the Gel
Maryam KaramiNogorani*#, Mazdak Goodarzian**
* Assistant Professor, Dept of Pediatric Dentistry, Dental School, Islamic Azad University Khorasgan Branch, Isfahan, Iran. ** Dentist
Received: 28 January 2010; Accepted: 20 July 2010
Introduction: Since compared to the fluoride gel, the fluoride varnish has received an increasing dentists’ attention, due to
some additional advantages including simple application especially in young children and less chair time, this study was done to compare the fluoride varnish and gel in terms of salivary concentration and longevity.
Materials & Methods: This clinical trial, approved by Islamic Azad University Khorasgan University of Medical
Sciences, was conducted with the participation of 10 randomly selected ten 12-14 year old volunteer boys. The salivary fluoride concentration was measured four times, before, after 30 minutes, seven and ten hours after fluoride therapy with gel and after a two-week interval with fluoride varnish, using fluoride ion selective electrode method. The data were statistically analyzed using Repeated Measure ANOVA, t and Paired-t tests.
Results: Thirty minutes and seven hours after fluoride therapy with varnish, salivary fluoride concentrations were
significantly higher than that of the base. However, after 10 hours, it reached to the base level. On the other hand, in the gel group, the salivary fluoride concentration was significantly higher than that of the base only after 30 minutes of treatment and after seven and ten hours it reached to the base level again. Comparing the two groups, the fluoride concentration of saliva was significantly higher in varnish group than in gel group after 30 minutes and 7 hours of treatment.
Conclusion: Salivary fluoride concentration after fluoride therapy with the varnish is significantly higher than fluoride therapy with the gel not only in terms of the quantity but also in terms of the longevity.
Key words: Fluoride therapy, fluoride varnish, fluoride gel.
# ##
#Corresponding Author: maryam_karami@yahoo.com
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1. Pinkham J, Casamassimo P, Fields HW, McTigue DJ, Nowak A. Pediatric Dentistry: Infancy Through Adolescence. 4th ed. London: Mosby Co; 2005. P. 193-205.
2. McDonald RE, Avery DR, Dean JA. Dentistry for the Child and Adolescent. 8th ed. St. Louis: Mosby Co; 2004. P. 265-301.
3. Ramaswami N. Fluoride varnish: A primary prevention tool for dental caries. J Mich Dent Assoc 2008; 90(1): 44-7.
4. Skold UM, Petersson LG, Birkhed D, Norlund A. Cost-analysis of school-based fluoride varnish and fluoride rinsing programs. Acta Odontol Scand 2008; 66(5): 286-92.
5. Miller EK, Vann WF Jr. The use of fluoride varnish in children: A critical review with treatment recommendations. J Clin Pediatr Dent 2008; 32(4): 259-64.
6. Xhemnica L, Sulo D, Rroco R, Hysi D. Fluoride varnish application: A new prophylactic method in Albania. Effect on enamel carious lesions in permanent dentition. Eur J Paediatr Dent 2008; 9(2): 93-6.
7. Yang G, Lin JH, Wang JH, Jiang L. Evaluation of the clinical effect of fluoride varnish in preventing caries of primary teeth. Hua Xi Kou Qiang Yi Xue Za Zhi 2008; 26(2): 159-61.
8. Chen SF, Lin HC. Dental service utilization and costs before and after introduction of fluoride gel application for preschool children in Taiwan. Health Policy 2009; 91(1): 94-101.
9. Peterson LG. Fluorine gradients in outermost surface enamel after various forms of topical application of fluorides in vivo. Odontol Revy 1976; 27(1): 25-50.
10. Villena RS, Tenuta LM, Cury JA. Effect of APF gel application time on enamel demineralization and fluoride uptake in situ. Braz Dent J 2009; 20(1): 37-41.
11. Jackson RD, Brizendine EJ, Kelly SA, Hinesley R, Stookey GK, Dunipace AJ. The fluoride content of foods and beverages from negligibly and optimally fluoridated communities. Community Dent Oral Epidemiol 2002; 30(5): 382-91.
12. Seppä L, Leppänen T, Hausen H. Fluoride varnish versus acidulated phosphate fluoride gel: A 3-year clinical trial. Caries Res 1995; 29(5): 327-30.
13. Santos Lde M, Reis JI, Medeiros MP, Ramos SM, Araújo JM. In vitro evaluation of fluoride products in the development of carious lesions in deciduous teeth. Braz Oral Res 2009; 23(3): 296-301.
14. Lee YE, Baek HJ, Choi YH, Jeong SH, Park YD, Song KB. Comparison of remineralization effect of three topical fluoride regimens on enamel initial carious lesions. J Dent 2010; 38(2): 166-71.
15. Davies GM, Bridgman C, Hough D, Davies RM. The application of fluoride varnish in the prevention and control of dental caries. Dent Update 2009; 36(7): 410-2.
16. Weintraub JA. Fluoride varnish for caries prevention: Comparisons with other preventive agents and recommendations for a community-based protocol. Spec Care Dentist 2003; 23(5): 180-6.
