Chagas' disease: an update on immune mechanisms and therapeutic strategies

As anomalias vasculares são um grupo grande e heterogéneo de doenças que podem ser divididos em dois grupos principais: as neoplasias vasculares - caracterizadas por uma

Key words: Trypanosoma cruzi - Calophyllum brasiliense - Mammea americana - coumarins - Chagas disease.. The protozoan Trypanosoma cruzi is the etiological agent of Chagas

Therapeutic failure of benznidazole (BZ) is widely documented in Chagas disease and has been primarily as- sociated with variations in the drug susceptibility of Trypanosoma cruzi

Altogether, cardiac tissue parasitism and inflam- mation, heart injury and ECG abnormalities were less intense in the chronically Colombian-infected C57BL/6 compared to

Role of parasite - The capacity of parasites to invade placental cells (see below), as well as their virulence and amount in pregnant women (particularly in retroplacen- tal

While no differences in the magnitude of T-cell responses specific for KMP-11 and HSP-70-derived peptides according to the clinical stage of the disease were found, IFN-γ

Key words: biological marker - Chagas disease - Trypanosoma cruzi - therapeutic response - parasite marker - host markers..

At the chronic phase of infection, parasite replication is counteracted by parasite killing mediated by cytotoxic CD8 + T-cell responses (indicated in Figure 1, top.. left), and