Distribution of genotypes C825T polymorphism G-protein β3-subunit gene in patients with hypertension depending on body mass index

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/ɋ.ɇ.Ʌɚɩɚɱ,Ⱥ.ȼ.ɑɭɛɟɧɤɨ,ɉ.ɇ.Ȼɚɛɢɱ. – 2-ɟ ɢɡɞ., ɩɟ-ɪɟɪɚɛ.ɢ ɞɨɩ. – Ʉ.:Ɇɨɪɢɨɧ, 2001. – 408 ɫ.

4. Ɇɚɟɜ ɂ.ȼ. Ƚɚɫɬɪɨɷɡɨɮɚɝɟɚɥɶɧɚɹ ɪɟɮɥɸɤɫɧɚɹ ɛɨɥɟɡɧɶ: ɨɬ ɩɚɬɨɝɟɧɟɡɚ ɤ ɬɟɪɚɩɟɜɬɢɱɟɫɤɢɦ ɚɫɩɟɤɬɚɦ / ɂ.ȼ.Ɇɚɟɜ,Ⱦ.Ⱦ.Ⱥɧɞɪɟɟɜ,Ⱦ.Ɍ.Ⱦɢɱɟɜɚ // Cons. Med. – 2013. – ʋ 8. – ɋ. 30-34.

5. Ɉɫɚɞɱɭɤ Ⱥ.Ɇ.Ɋɟɮɪɚɤɬɟɪɧɚɹ ɮɨɪɦɚ ɝɚɫɬɪɨɷɡɨ-ɮɚɝɟɚɥɶɧɨɣ ɪɟɮɥɸɤɫɧɨɣ ɛɨɥɟɡɧɢ.Ⱥɤɬɭɚɥɶɧɵɟ ɢ ɧɟɪɟ -ɲɟɧɧɵɟ ɜɨɩɪɨɫɵ ɤɨɧɫɟɪɜɚɬɢɜɧɨɣ ɬɟɪɚɩɢɢ / Ⱥ.Ɇ.Ɉɫɚɞɱɭɤ, ɂ.Ʌ.Ⱦɚɜɵɞɤɢɧ, Ɇ.Ƚ.ɉɚɥɭɲɤɢɧɚ // Ɇɟɞ.ɚɥɶɦɚɧɚɯ. – 2012. – ʋ 1. – ɋ. 29-34.

6. ɋɬɟɩɚɧɨɜ ɘ.Ɇ. ɋɨɞɟɪɠɚɧɢɟ ɫɵɜɨɪɨɬɨɱɧɨɝɨ ɝɚɫɬɪɢɧɚ ɭ ɩɚɰɢɟɧɬɨɜ ɫ ɪɟɮɥɸɤɫ-ɝɚɫɬɪɢɬɨɦ /

ɘ.Ɇ.ɋɬɟɩɚɧɨɜ, Ʌ.ɇ.Ɇɨɫɢɣɱɭɤ, Ⱥ.ɇ.Ʉɨɜɚɥɟɧɤɨ // Ƚɚɫɬɪɨɟɧɬɟɪɨɥɨɝɿɹ. – 2014. – ʋ 2. – ɋ. 32-36.

7. Ɏɭɧɤɰɿɨɧɚɥɶɧɿ ɡɚɯɜɨɪɸɜɚɧɧɹ ɨɪɝɚɧɿɜ ɬɪɚɜɥɟɧ-ɧɹ: ɧɚɜɱ. ɩɨɫɿɛɧɢɤ / Ɍ.Ⱦ.Ɂɜɹɝɿɧɰɟɜɚ, Ɉ.ȱ.ɋɟɪɝɿɽɧɤɨ, ɑɟɪɧɨɛɚɣ Ⱥ.ȱ. [ɬɚ ɿɧ.]. – ɏɚɪɤɿɜ:Ɍɨɱɤɚ, 2010. – 167 ɫ.

8. Alkaline reflux gastritis: early and late results of surgery / B. Zobolas, G.H. Sakorafas, I. Kouroukli [et al.] // World J. Surg.— 2006.— Vol. 30, N 6.— P. 1043-1049.

9. Correlation between duodenogastric reflux and remnant gastritis after distal gastrectomy / K. Fukuhara, H. Osugi, N. Takada [et al.] // Hepatogastroenterology. – 2004. – Vol. 51, N 58. – P. 1241-1244.

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1. Bufan MM [Comparative effectiveness of integrated and optimized treatment of chronic gastritis with duodenal regurgitation]. Praktychna medycina. 2007;3:6-10. Ukraine.

2. Zvyagintseva TD, Gamanenko YK [Chronic gastritis] Liky Ukraine. 2012;3(2):28-32. Russian.

3. Statistical methods in biomedical research using Excel. 2 izd. Ʉ.:Ɇɨrion-2001;408-15. Russian.

4. Maev IV, Andreev DD, Dycheva DT. [Gastro-esophageal reflux disease: from pathogenesis to thera-peutic aspects]. Cons. Med. 2013;8:30-4. Russian.

5. Osadchuk ȺɆ, Davydykin IL, Palushkina MG.[ Refractory form of gastroesophageal reflux disease. Ac-tual and unsolved problems of conservative therapy]. Ɇed. almanax. 2012;1:29-34. Russian.

6. Stepanov YuM, Mosiychuk LN, Kovalenko AN. [Serum gastrin levels in patients with reflux gastritis ]. Gastroenterology. 2014;2:32-36. Russian.

7. Zvyagintseva TD. [Functional diseases of the di-gestive system] Navchalnyi posibnyk. Kharkiv: Ɍɨchka, 2010;167. Ukraine.

8. Zobolas B, Sakorafas G.H, Kouroukli I. Alkaline reflux gastritis: early and late results of surgery. World J. Sur. 2006;6:1043-9.

9. Fukuhara K, Osugi H, Takada N. Correlation between duodenogastric reflux and remnant gastritis after distal gastrectomy. Hepatogastroenterology. 2004;58:1241-4.

ɋɬɚɬɬɹ ɧɚɞɿɣɲɥɚ ɞɨ ɪɟɞɚɤɰɿʀ 03.07.2015

ɍȾɄ 616.12-008.331.1:613.25: 575.22:548.33

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ɋɭɦɫɶɤɢɣ ɞɟɪɠɚɜɧɢɣ ɭɧɿɜɟɪɫɢɬɟɬ,ɦɟɞɢɱɧɢɣ ɿɧɫɬɢɬɭɬ ɤɚɮɟɞɪɚ ɜɧɭɬɪɿɲɧɶɨʀ ɦɟɞɢɰɢɧɢ ɩɿɫɥɹɞɢɩɥɨɦɧɨʀ ɨɫɜɿɬɢ ɜɭɥ.Ɋɢɦɫɶɤɨɝɨ-Ʉɨɪɫɚɤɨɜɚ, 2, ɋɭɦɢ, 40007, ɍɤɪɚʀɧɚ Sumy state university, medical faculty

department of internal deseases

Ryms'kogo-Korsakova str., 2, Sumy, 40007, Ukraine *[email protected]

Ʉɥɸɱɨɜɿ ɫɥɨɜɚ:ɚɪɬɟɪɿɚɥɶɧɚ ɝɿɩɟɪɬɟɧɡɿɹ,ɋ825Ɍ ɩɨɥɿɦɨɪɮɿɡɦ, GNB3, ɨɠɢɪɿɧɧɹ

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15/

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ɩɪɨɬɟɢɧɚ (GNB3) ɭ ɛɨɥɶɧɵɯ ɚɪɬɟɪɢɚɥɶɧɨɣ ɝɢɩɟɪɬɟɧɡɢɟɣ (ȺȽ)ɜ ɡɚɜɢɫɢɦɨɫɬɢ ɨɬ ɢɧɞɟɤɫɚ ɦɚɫɫɵ ɬɟɥɚ (ɂɆɌ). ȼ ɢɫɫɥɟɞɨɜɚɧɢɢ ɩɪɢɧɢɦɚɥɨ ɭɱɚɫɬɢɟ 155 ɩɚɰɢɟɧɬɨɜ ɫ ɜɟɪɢɮɢɰɢɪɨɜɚɧɧɵɦ ɞɢɚɝɧɨɡɨɦ ȺȽ (ɨɫɧɨɜɧɚɹ ɝɪɭɩɩɚ) ɢ 50 ɩɪɚɤɬɢɱɟɫɤɢ ɡɞɨɪɨɜɵɯ ɥɢɰ (ɤɨɧɬɪɨɥɶɧɚɹ ɝɪɭɩɩɚ). ɉɚɰɢɟɧɬɵ ɨɫɧɨɜɧɨɣ ɝɪɭɩɩɵ ɛɵɥɢ ɪɚɡɞɟɥɟɧɵ ɧɚ 3 ɝɪɭɩɩɵ ɜ ɡɚɜɢɫɢɦɨɫɬɢ ɨɬ ɂɆɌ: I - 35 ɩɚɰɢɟɧɬɨɜ ɫ ɧɨɪɦɚɥɶɧɨɣ ɦɚɫɫɨɣ ɬɟɥɚ, II - 38 ɩɚɰɢɟɧɬɨɜ ɫ ɢɡɛɵɬɨɱɧɨɣ ɦɚɫɫɨɣ ɬɟɥɚ, III - 82 ɩɚɰɢɟɧɬɚ ɫ ɨɠɢɪɟɧɢɟɦ. ȼ ɪɚɛɨɬɟ ɢɫɩɨɥɶɡɨɜɚɥɢ ɨɛɳɟɤɥɢɧɢɱɟɫɤɢɟ, ɚɧɬɪɨɩɨɦɟɬɪɢɱɟɫɤɢɟ, ɢɧɫ-ɬɪɭɦɟɧɬɚɥɶɧɵɟ, ɦɨɥɟɤɭɥɹɪɧɨ-ɝɟɧɟɬɢɱɟɫɤɢɟ ɢ ɫɬɚɬɢɫɬɢɱɟɫɤɢɟ ɦɟɬɨɞɵ ɢɫɫɥɟɞɨɜɚɧɢɹ. Ⱦɨɫɬɨɜɟɪɧɨɫɬɶ ɪɚɡ-ɥɢɱɢɣ ɱɚɫɬɨɬɵ ɚɥɥɟɥɟɣ ɢ ɝɟɧɨɬɢɩɨɜ ɨɩɪɟɞɟɥɹɥɢ ɫ ɩɨɦɨɳɶɸ ɤɪɢɬɟɪɢɹ Ȥ². ɉɨɩɚɪɧɨɟ ɫɪɚɜɧɟɧɢɟ ɝɪɭɩɩ ɫ ɩɨɦɨɳɶɸ ɧɟɩɚɪɚɦɟɬɪɢɱɟɫɤɨɝɨ ɬɟɫɬɚ Ɇɚɧɧɚ-ɍɢɬɧɢ.Ɋɚɡɧɢɰɭ ɫɱɢɬɚɥɢ ɫɬɚɬɢɫɬɢɱɟɫɤɢ ɡɧɚɱɢɦɨɣ ɩɪɢ ɪ <0,05. ɂɫɫɥɟɞɨɜɚɧɢɟ ɪɚɫɩɪɟɞɟɥɟɧɢɹ ɝɟɧɨɬɢɩɨɜ ɋ825Ɍ ɩɨɥɢɦɨɪɮɢɡɦɚ ɝɟɧɚ GNB3 ɭ ɩɚɰɢɟɧɬɨɜ ɫ ȺȽ ɜ ɡɚɜɢɫɢɦɨɫɬɢ ɨɬ ɂɆɌ ɜɵɹɜɢɥɨ ɫɬɚɬɢɫɬɢɱɟɫɤɢ ɞɨɫɬɨɜɟɪɧɨɟ ɭɜɟɥɢɱɟɧɢɟ ɱɚɫɬɨɬɵ ɝɟɧɨɬɢɩɨɜ ɋ / Ɍ,Ɍ / Ɍ ɢ Ɍ ɚɥɥɟɥɹ ɭ ɩɚɰɢɟɧɬɨɜ ɫ ɢɡɛɵɬɨɱɧɨɣ ɦɚɫɫɨɣ ɬɟɥɚ ɢ ɨɠɢɪɟɧɢɟɦ ɜ ɫɪɚɜɧɟɧɢɢ ɫ ɩɚɰɢɟɧɬɚɦɢ ɫ ɧɨɪɦɚɥɶɧɨɣ ɦɚɫɫɨɣ ɬɟɥɚ (Ȥ² = 26,8; ɪ <0,001). Ɋɢɫɤ ɭɜɟɥɢɱɟɧɢɹ ɦɚɫɫɵ ɬɟɥɚ ɭ ɛɨɥɶɧɵɯ ȺȽ ɧɨɫɢɬɟɥɟɣ Ɍ ɚɥɥɟɥɹ ɜ 2,2 ɪɚɡɚ ɜɵɲɟ, ɱɟɦ ɭ ɧɨɫɢɬɟɥɟɣ ɋ ɚɥɥɟɥɹ. Ⱦɨɤɚɡɚɧɨ ɚɫɫɨɰɢɚɰɢɸ ɋ825Ɍ ɩɨɥɢɦɨɪɮɢɡɦɚ ɝɟɧɚ GNB3 ɫɨ ɫɤɥɨɧɧɨɫɬɶɸ ɤ ɨɠɢɪɟɧɢɸ ɢ ɢɡɛɵɬɨɱɧɨɣ ɦɚɫɫɟ ɬɟɥɚ ɭ ɛɨɥɶɧɵɯ ȺȽ.

Abstract. Distribution of genotypes C825T polymorphism G-protein ȕ3-subunit gene in patients with hypertension depending on body mass index. Prystupa L.N., Moisejenko I.O. The aim of the study was to investigate the frequency of genotypes of C825T polymorphism G-protein ȕ3-subunit gene (GNB3) in patients with arterial hypertension (AH), depending on body mass index (BMI). The study involved 155 patients with verified diagnosis of AH (study group) and 50 healthy individuals (control group). The patients of the main group were divided into 3 groups according to BMI: I - 35 patients with normal body weight, II - 38 patients with overweight, III - 82 patients with obesity. We used general clinical, anthropometric, instrumental, molecular-genetic and statistical methods. Probability of differences in the frequency of alleles and genotypes was determined using Ȥ² criteria. Pairwise comparison of groups was made using nonparametric Mann-Whitney test. The difference was considered statistically significant at p <0,05. Investigation of the distribution of genotypes C825T polymorphism GNB3 in patients with AH according to BMI showed statistically significant increase in the frequency of genotypes C / T and T / T and T allele in patients with overweight and obesity as compared with patients with normal body weight (Ȥ² = 26 8; p <0.001). The risk of weight increase in AH patients with T allele carriers is 2,2 times higher than in C allele carriers. Association of C825T polymorphism of GNB3 with a tendency to obesity and overweight in patients with AH was proved.

Ⱥɪɬɟɪɿɚɥɶɧɚ ɝɿɩɟɪɬɟɧɡɿɹ (ȺȽ) ɡɚɥɢɲɚɽɬɶɫɹ ɨɞɧɿɽɸ ɡ ɧɚɣɛɿɥɶɲ ɚɤɬɭɚɥɶɧɢɯ, ɫɤɥɚɞɧɢɯ ɬɚ ɤɨɦ -ɩɥɟɤɫɧɢɯ ɦɟɞɢɤɨ-ɫɨɰɿɚɥɶɧɢɯ ɩɪɨɛɥɟɦ ɫɭɱɚɫɧɨʀ ɦɟɞɢɰɢɧɢ [1]. Ɋɢɡɢɤ ɫɟɪɰɟɜɨ-ɫɭɞɢɧɧɢɯ ɤɚ -ɬɚɫɬɪɨɮ ɩɪɢ ȺȽ ɡɪɨɫɬɚɽ ɩɪɨɩɨɪɰɿɣɧɨ ɡɛɿɥɶɲɟɧ -ɧɸ ɿɧɞɟɤɫɭ ɦɚɫɢ ɬɿɥɚ (ȱɆɌ).Ɂɚ ɞɚɧɢɦɢ ɫɭɱɚɫɧɢɯ ɞɨɫɥɿɞɠɟɧɶ, ɩɿɞɜɢɳɟɧɧɹ ɚɪɬɚɪɿɚɥɶɧɨɝɨ ɬɢɫɤɭ (ȺɌ) ɜɢɹɜɥɹɽɬɶɫɹ ɧɟ ɬɿɥɶɤɢ ɩɪɢ ɨɠɢɪɿɧɧɿ, ɚɥɟ ɿ ɩɪɢ ɧɟɡɧɚɱɧɨɦɭ ɡɛɿɥɶɲɟɧɧɿ ɦɚɫɢ ɬɿɥɚ, ɬɨɦɭ ɧɟɨɛɯɿɞɧɨ ɡɜɟɪɬɚɬɢ ɨɫɨɛɥɢɜɭ ɭɜɚɝɭ ɹɤ ɧɚ ɩɚ -ɰɿɽɧɬɿɜ ɡ ɨɠɢɪɿɧɧɹɦ, ɬɚɤ ɿ ɡ ɧɚɞɦɿɪɧɨɸ ɦɚɫɨɸ ɬɿɥɚ [6].

Ɉɠɢɪɿɧɧɹ ɽ ɯɪɨɧɿɱɧɢɦ ɩɨɥɿɟɬɿɨɥɨɝɿɱɧɢɦ ɡɚ -ɯɜɨɪɸɜɚɧɧɹɦ,ɳɨ ɩɨɜ’ɹɡɚɧɟ ɡ ɧɢɡɤɨɸ ɝɟɧɟɬɢɱɧɢɯ ɮɚɤɬɨɪɿɜ, ɡɦɿɧɨɸ ɮɭɧɤɰɿʀ ɟɧɞɨɤɪɢɧɧɨʀ ɫɢɫɬɟɦɢ, ɨɛɦɿɧɭ ɪɟɱɨɜɢɧ, ɫɬɢɥɸ ɠɢɬɬɹ ɿ ɯɚɪɱɨɜɢɦɢ ɡɜɢɱɤɚɦɢ ɨɫɨɛɢ [2]. ȼ ɟɤɨɧɨɦɿɱɧɨ ɪɨɡɜɢɧɟɧɢɯ ɤɪɚʀɧɚɯ ɦɚɣɠɟ 50% ɧɚɫɟɥɟɧɧɹ ɦɚɽ ɡɚɣɜɭ ɜɚɝɭ, ɩɪɢ ɰɶɨɦɭ ɭ 30% ɡ ɧɢɯ ɫɩɨɫɬɟɪɿɝɚɽɬɶɫɹ ɨɠɢɪɿɧɧɹ. ȼ ɍɤɪɚʀɧɿ ɡɚɣɜɭ ɜɚɝɭ ɦɚɽ ɤɨɠɧɚ ɱɟɬɜɟɪɬɚ ɠɿɧɤɚ ɿ ɤɨɠɟɧ ɲɨɫɬɢɣ ɱɨɥɨɜɿɤ, ɛɥɢɡɶɤɨ 30% ɧɚɫɟɥɟɧɧɹ ɫɬɪɚɠɞɚɽ ɜɿɞ ɨɠɢɪɿɧɧɹ [3].

Ƚɟɧɟɬɢɱɧɿ ɞɨɫɥɿɞɠɟɧɧɹ ɞɨɜɨɞɹɬɶ ɚɫɨɰɿɚɰɿɸ ɧɚɞɦɿɪɧɨʀ ɦɚɫɢ ɬɿɥɚ ɬɚ ɨɠɢɪɿɧɧɹ ɡ ɩɨɥɿɦɨɪ -ɮɿɡɦɨɦ ɝɟɧɿɜ ɚɧɝɿɨɬɟɧɡɢɧɩɟɪɟɬɜɨɪɸɸɱɨɝɨ ɮɟɪ

-ɦɟɧɬɭ, ɚɞɢɩɨɧɟɤɬɢɧɭ, ɥɟɩɬɢɧɭ, ɥɿɩɚɡɢ, ȕ 3-ɫɭɛɨɞɢɧɢɰɿ G-ɩɪɨɬɟʀɧɭ (GNB3) ɬɚ ɿɧ. [8]. ɍ ɡɜ'ɹɡɤɭ ɡ ɰɢɦ, ɜɟɥɢɤɭ ɭɜɚɝɭ ɩɪɢɞɿɥɹɸɬɶ ɞɨɫɥɿɞ -ɠɟɧɧɸ ɧɟɳɨɞɚɜɧɨ ɨɩɢɫɚɧɨɝɨ ɋ825Ɍ ɩɨɥɿɦɨɪ -ɮɿɡɦɭ ɝɟɧɚ ȕ3-ɫɭɛɨɞɢɧɢɰɿ G-ɩɪɨɬɟʀɧɭ (GNB3).

G-ɩɪɨɬɟʀɧ ɫɤɥɚɞɚɽɬɶɫɹ ɡ 3-ɯ ɫɭɛɨɞɢɧɢɰɶ (Į, ß, Ȗ), ɤɨɠɧɚ ɡ ɹɤɢɯ, ɩɪɢ ɜɡɚɽɦɨɞɿʀ ɦɟɞɿɚɬɨɪɚ ɿ G-ɩɪɨɬɟʀɧ-ɩɨɜ'ɹɡɚɧɢɯ ɪɟɰɟɩɬɨɪɿɜ, ɦɨɠɟ ɚɤɬɢɜɭɜɚɬɢ ɛɟɡɥɿɱ ɟɮɟɤɬɨɪɿɜ, ɬɚɤɢɯ ɹɤ ɿɨɧɧɿ ɤɚɧɚɥɢ, ɮɨɫ -ɮɨɥɿɩɚɡɭ ɋ,ɚɞɟɧɿɥɚɬ-ɰɢɤɥɚɡɧɭ ɫɢɫɬɟɦɭ ɬɚ ɿɧ.,ɳɨ ɭ ɫɜɨɸ ɱɟɪɝɭ ɩɪɢɡɜɨɞɢɬɶ ɞɨ ɤɥɿɬɢɧɧɨʀ ɜɿɞɩɨɜɿɞɿ, ɹɤɚ ɪɟɚɥɿɡɭɽɬɶɫɹ ɱɟɪɟɡ ɝɨɪɦɨɧɚɥɶɧɭ ɫɟɤɪɟɰɿɸ. Ⱥɧɚɥɿɡ ɝɟɧɿɜ Į-ɫɭɛɨɞɢɧɢɰɿ (GNAS), ȕ-ɫɭɛɨɞɢɧɢɰi (GNB) ɬɚ Ȗ-ɫɭɛɨɞɢɧɢɰɿ (GNG) ɜɢɹɜɢɜ ɬɨɱɤɨɜɢɣ ɩɨɥɿɦɨɪɮɿɡɦ ɭ ɝɟɧɿ ȕ3-ɫɭɛɨɞɢɧɢɰɿ, ɪɨɡɬɚɲɨ -ɜɚɧɨɦɭ ɜ ɯɪɨɦɨɫɨɦɿ 12ɪ13, ɳɨ ɩɨɥɹɝɚɽ ɜ ɡɚɦɿɧɿ ɰɢɬɨɡɢɧɭ (ɋ) ɧɚ ɬɢɦɿɧ (Ɍ) ɭ 825-ɣ ɩɨɡɢɰɿʀ (ɋ825Ɍ), ɳɨ ɜɿɞɩɨɜɿɞɚɽ ɡɚ ɩɟɪɟɞɚɱɭ ɫɢɝɧɚɥɿɜ ɜɿɞ ɦɟɦɛɪɚɧɧɢɯ ɪɟɰɟɩɬɨɪɿɜ ɞɨ ɜɧɭɬɪɿɲɧɿɯ ɫɬɪɭɤɬɭɪ [14].

(3)

ɄɅȱɇȱɑɇȺ ɆȿȾɂɐɂɇȺ

ɩɿɞɬɜɟɪɞɠɟɧɧɹ ɿ ɜ ɩɨɞɚɥɶɲɢɯ ɞɨɫɥɿɞɠɟɧɧɹɯ [15]. ɇɢɡɤɨɸ ɞɨɫɥɿɞɠɟɧɶ ɜɫɬɚɧɨɜɥɟɧɨ, ɳɨ Ɍ ɚɥɟɥɶ ɚɫɨɰɿɣɨɜɚɧɢɣ ɡ ɧɚɤɨɩɢɱɟɧɧɹɦ ɠɢɪɨɜɨʀ ɬɤɚɧɢɧɢ ɜ ɬɿɥɿ, ɚ ɩɢɬɨɦɚ ɜɚɝɚ ɠɢɪɨɜɨʀ ɬɤɚɧɢɧɢ ɭ ɧɨɫɿʀɜ T/T ɝɟɧɨɬɢɩɭ ɡɧɚɱɧɨ ɜɢɳɚ, ɧɿɠ ɭ ɧɨɫɿʀɜ ɋ/ɋ ɬɚ ɋ/Ɍ ɝɟɧɨɬɢɩɿɜ [12, 17]. Ʉɪɿɦ ɬɨɝɨ, T/T ɬɚ ɋ/Ɍ ɝɟɧɨ -ɬɢɩɢ ɽ ɩɪɨɝɧɨɫɬɢɱɧɨ ɫɩɪɢɹɬɥɢɜɿɲɢɦɢ ɳɨɞɨ ɿɧɬɟɧɫɢɜɧɨɫɬɿ ɜɬɪɚɬɢ ɜɚɝɢ, ɧɿɠ C/ɋ ɝɟɧɨɬɢɩ ɭ ɩɚɰɿɽɧɬɿɜ ɡ ɨɠɢɪɿɧɧɹɦ [11].

ɉɪɨɬɟ ɞɨɫɥɿɞɠɟɧɧɹ, ɩɪɨɜɟɞɟɧɿ ɹɩɨɧɫɶɤɢɦɢ ɜɱɟɧɢɦɢ, ɩɨɤɚɡɚɥɢ, ɳɨ C825T ɩɨɥɿɦɨɪɮɿɡɦ ɜɩɥɢɜɚɽ ɧɚ ɥɿɩɿɞɧɢɣ ɨɛɦɿɧ ɿ ɧɟ ɚɫɨɰɿɣɨɜɚɧɢɣ ɡ ȺȽ, ɨɠɢɪɿɧɧɹɦ, ɪɟɡɢɫɬɟɧɬɧɿɫɬɸ ɞɨ ɿɧɫɭɥɿɧɭ, ɰɭɤɪɨɜɢɦ ɞɿɚɛɟɬɨɦ [13].

Ɂɜɚɠɚɸɱɢ ɧɚ ɫɭɩɟɪɟɱɥɢɜɿ ɪɟɡɭɥɶɬɚɬɢ ɞɨ -ɫɥɿɞɧɢɤɿɜ ɬɚ ɜɿɞɫɭɬɧɿɫɬɶ ɞɚɧɢɯ ɩɪɨ ɱɚɫɬɨɬɭ ɝɟɧɨɬɢɩɿɜ ɡɚ ɋ825Ɍ ɩɨɥɿɦɨɪɮɿɡɦɨɦ ɝɟɧɚ GNB3 ɭ ɯɜɨɪɢɯ ɧɚ ȺȽ ɜ ɍɤɪɚʀɧɿ, ɦɟɬɨɸ ɰɶɨɝɨ ɞɨɫɥɿɞ -ɠɟɧɧɹ ɛɭɥɨ ɜɢɜɱɟɧɧɹ ɱɚɫɬɨɬɢ ɝɟɧɨɬɢɩɿɜ ɡɚ ɋ825Ɍ ɩɨɥɿɦɨɪɮɿɡɦɨɦ ɝɟɧɚ GNB3 ɭ ɯɜɨɪɢɯ ɧɚ ȺȽ ɡɚɥɟɠɧɨ ɜɿɞ ȱɆɌ.

ɆȺɌȿɊȱȺɅɂ ɌȺ ɆȿɌɈȾɂ ȾɈɋɅȱȾɀȿɇɖ ɍ ɞɨɫɥɿɞɠɟɧɧɿ ɛɪɚɥɢ ɭɱɚɫɬɶ 155 ɩɚɰɿɽɧɬɿɜ ɡ ɜɟɪɢɮɿɤɨɜɚɧɢɦ ɞɿɚɝɧɨɡɨɦ ȺȽ (ɨɫɧɨɜɧɚ ɝɪɭɩɚ) ɬɚ 50 ɩɪɚɤɬɢɱɧɨ ɡɞɨɪɨɜɢɯ ɨɫɿɛ (ɤɨɧɬɪɨɥɶɧɚ ɝɪɭɩɚ). Ⱦɿɚɝɧɨɡ ȺȽ ʉɪɭɧɬɭɜɚɜɫɹ ɧɚ ɤɪɢɬɟɪɿɹɯ ȼɈɈɁ (1999)ɬɚ ɪɟɤɨɦɟɧɞɚɰɿɹɯ ɍɤɪɚʀɧɫɶɤɨɝɨ ɬɨɜɚɪɢɫɬɜɚ ɤɚɪɞɿɨɥɨɝɿɜ (2012) [5].

ȱɆɌ ɪɨɡɪɚɯɨɜɚɜɫɹ ɡɚ ɮɨɪɦɭɥɨɸ: ɦɚɫɚ ɬɿɥɚ (ɤɝ)/ɜɢɦɿɪɹɧɢɣ ɡɪɿɫɬ (ɦ2). ȱɆɌ ɞɨ 24,9 ɤɝ/ɦ2 ɩɪɢɣɦɚɥɢ ɡɚ ɧɨɪɦɚɥɶɧɭ ɦɚɫɭ ɬɿɥɚ, 25,0í29,9 ɤɝ/ɦ2í ɧɚɞɥɢɲɤɨɜɭ ɦɚɫɭ ɬɿɥɚ, ɚ ɩɨɧɚɞ 30 ɤɝ/ɦ2 – ɨɠɢɪɿɧɧɹ [2]. ɉɚɰɿɽɧɬɢ ɨɫɧɨɜɧɨʀ ɝɪɭɩɢ ɛɭɥɢ ɪɨɡɩɨɞɿɥɟɧɿ ɧɚ 3 ɝɪɭɩɢ ɡɚɥɟɠɧɨ ɜɿɞ ȱɆɌ. I ɝɪɭɩɭ ɫɤɥɚɥɢ 35 ɩɚɰɿɽɧɬɿɜ ɡ ɧɨɪɦɚɥɶɧɨɸ ɦɚɫɨɸ ɬɿɥɚ, II

ɝɪɭɩɭ – 38 ɩɚɰɿɽɧɬɿɜ ɿɡ ɧɚɞɦɿɪɧɨɸ ɦɚɫɨɸ ɬɿɥɚ, III ɝɪɭɩɭ – 82 ɩɚɰɿɽɧɬɢ ɡ ɨɠɢɪɿɧɧɹɦ.

ȼɢɡɧɚɱɟɧɧɹ ɩɨɥɿɦɨɪɮɿɡɦɭ ɋ825Ɍ ɝɟɧɚ GNB3 (rs5443) ɩɪɨɜɨɞɢɥɢ ɦɟɬɨɞɨɦ ɩɨɥɿɦɟɪɚɡɧɨʀ ɥɚɧ -ɰɸɝɨɜɨʀ ɪɟɚɤɰɿʀ ɡ ɩɨɞɚɥɶɲɢɦ ɚɧɚɥɿɡɨɦ ɪɟɫɬɪɢɤ -ɰɿɣɧɢɯ ɮɪɚɝɦɟɧɬɿɜ [14].

ɋɬɚɬɢɫɬɢɱɧɭ ɨɛɪɨɛɤɭ ɞɚɧɢɯ ɩɪɨɜɨɞɢɥɢ ɡɚ ɞɨɩɨɦɨɝɨɸ ɩɪɨɝɪɚɦɢ SPSS Statistics 21. ȼɿɪɨɝɿɞ -ɧɿɫɬɶ ɜɿɞɦɿɧɧɨɫɬɟɣ ɱɚɫɬɨɬɢ ɚɥɟɥɿɜ ɿ ɝɟɧɨɬɢɩɿɜ ɜɢɡɧɚɱɚɥɢ ɡɚ ɞɨɩɨɦɨɝɨɸ ɤɪɢɬɟɪɿɸ Ȥ². Ⱦɥɹ ɩɨ -ɩɚɪɧɨɝɨ ɩɨɪɿɜɧɹɧɧɹ ɝɪɭɩ ɜɢɤɨɪɢɫɬɨɜɭɜɚɥɢ ɧɟɩɚ -ɪɚɦɟɬɪɢɱɧɢɣ ɬɟɫɬ Ɇɚɧɧɚ-ɍɿɬɧɿ.Ɋɿɡɧɢɰɸ ɜɜɚɠɚɥɢ ɫɬɚɬɢɫɬɢɱɧɨ ɜɿɪɨɝɿɞɧɨɸ ɩɪɢ ɪ<0,05. Ⱦɥɹ ɨɩɢɫɭ ɜɿɞɧɨɫɧɨɝɨ ɪɢɡɢɤɭ ɪɨɡɜɢɬɤɭ ɡɚɯɜɨɪɸɜɚɧɧɹ ɪɨɡ -ɪɚɯɨɜɭɜɚɥɢ ɜɿɞɧɨɲɟɧɧɹ ɲɚɧɫɿɜ (ȼɒ)ɬɚ ɞɨɜɿɪɱɢɣ ɿɧɬɟɪɜɚɥ (Ⱦȱ) [4].

ɊȿɁɍɅɖɌȺɌɂ ɌȺ Ȳɏ ɈȻȽɈȼɈɊȿɇɇə

Ⱥɧɚɥɿɡ ɪɨɡɩɨɞɿɥɭ ɝɟɧɨɬɢɩɿɜ ɿ ɚɥɟɥɿɜ ɡɚ ɋ825Ɍ ɩɨɥɿɦɨɪɮɿɡɦɨɦ ɝɟɧɚ GNB3 ɭ ɤɨɧɬɪɨɥɶɧɿɣ ɝɪɭɩɿ ɩɨɤɚɡɚɜ,ɳɨ 28 ɨɫɿɛ (56%) ɛɭɥɢ ɝɨɦɨɡɢɝɨɬɧɿ ɡɚ ɋ ɚɥɟɥɟɦ (ɋ/ɋ ɝɟɧɨɬɢɩ), 19 ɨɫɿɛ (38%) – ɝɟɬɟɪɨ -ɡɢɝɨɬɧɿ (Ɍ/ɋ), 3 ɨɫɨɛɢ (6%) í ɝɨɦɨɡɢɝɨɬɢ ɡɚ Ɍ ɚɥɟɥɟɦ (Ɍ/Ɍ ɝɟɧɨɬɢɩ), ɚ ɱɚɫɬɨɬɚ ɚɥɟɥɸ ɋ ɫɬɚ -ɧɨɜɢɥɚ 56%, Ɍ í 44%. Ɋɨɡɩɨɞɿɥ ɝɟɧɨɬɢɩɿɜ ɬɚ ɚɥɟ -ɥɿɜ ɭ ɯɜɨɪɢɯ ɧɚ ȺȽ ɬɚɤɢɣ: 49 ɨɫɿɛ (31,6%) ɛɭɥɢ ɝɨɦɨɡɢɝɨɬɧɿ ɡɚ ɋ ɚɥɟɥɟɦ (ɋ/ɋ ɝɟɧɨɬɢɩ), 86 ɨɫɿɛ (55,5%) – ɝɟɬɟɪɨɡɢɝɨɬɧɿ (Ɍ/ɋ), 20 ɨɫɿɛ (12,9%) í ɝɨɦɨɡɢɝɨɬɢ ɡɚ Ɍ ɚɥɟɥɟɦ (Ɍ/Ɍ ɝɟɧɨɬɢɩ), ɱɚɫɬɨɬɚ ɚɥɟɥɸ ɋ ɫɬɚɧɨɜɢɥɚ 31,6%, Ɍ – 68,4%. Ⱥɧɚɥɿɡɭɸɱɢ ɪɨɡɩɨɞɿɥ ɱɚɫɬɨɬ ɝɟɧɨɬɢɩɿɜ ɋ/ɋ,ɋ/Ɍ ɬɚ Ɍ/Ɍ ɡɚ ɋ825Ɍ ɩɨɥɿɦɨɪɮɿɡɦɨɦ ɭ ɤɨɧɬɪɨɥɶɧɿɣ ɬɚ ɨɫɧɨɜɧɿɣ ɝɪɭɩɚɯ, ɜɢɹɜɥɟɧɨ ɫɬɚɬɢɫɬɢɱɧɨ ɡɧɚɱɭɳɭ ɪɿɡɧɢɰɸ (ɪ=0,02).

Ɋɨɡɩɨɞɿɥ ɝɟɧɨɬɢɩɿɜ ɡɚ ɋ825Ɍ ɩɨɥɿɦɨɪɮɿɡɦɨɦ ɝɟɧɚ GNB3 ɭ ɯɜɨɪɢɯ ɧɚ ȺȽ ɡɚɥɟɠɧɨ ɜɿɞ ȱɆɌ ɩɪɟɞɫɬɚɜɥɟɧɢɣ ɭ ɬɚɛɥɢɰɿ 1.

Ɍ ɚ ɛ ɥ ɢ ɰ ɹ 1

Ɋɨɡɩɨɞɿɥ ɝɟɧɨɬɢɩɿɜ ɡɚ ɋ

825 Ɍ ɩɨɥɿɦɨɪɮɿɡɦɨɦ ɝɟɧɚ

GNB3

ɭ ɯɜɨɪɢɯ ɧɚ ɚɪɬɟɪɿɚɥɶɧɭ ɝɿɩɟɪɬɟɧɡɿɸ ɡɚɥɟɠɧɨ ɜɿɞ ɿɧɞɟɤɫɭ ɦɚɫɢ ɬɿɥɚ

Ƚɪɭɩɢ

I, n=35 II, n=38 III, n=82

ɉɨɤɚɡɧɢɤ

n % n % n %

C/Cɝɟɧɨɬɢɩ 16 45,7 11 29 22 26,8 C/Tɝɟɧɨɬɢɩ 14 40 23 60,5 49 59,8 T/Tɝɟɧɨɬɢɩ 5 14,3 4 10,5 11 13,4 Cɚɥɟɥɶ 16 45,7 11 28,9 22 26,8 Tɚɥɟɥɶ 19 54,3 27 71,1 60 73,2

ɯ2 _26,8

(4)

15/

Ɍɨɦ

XX / 3

ɝɪɭɩɿ ɡ ɧɨɪɦɚɥɶɧɨɸ ɦɚɫɨɸ ɬɿɥɚ, ɜ ɫɜɨɸ ɱɟɪɝɭ Ɍ ɚɥɟɥɶ ɭ ɝɪɭɩɿ ɡ ɨɠɢɪɿɧɧɹɦ ɡɭɫɬɪɿɱɚɽɬɶɫɹ ɧɚ 18% ɱɚɫɬɿɲɟ, ɧɿɠ ɭ ɝɪɭɩɿ ɡ ɧɨɪɦɚɥɶɧɨɸ ɦɚɫɨɸ ɬɿɥɚ. Ɋɿɡɧɢɰɿ ɱɚɫɬɨɬɢ Ɍ ɚɥɟɥɹ ɦɿɠ ɯɜɨɪɢɦɢ ɡ ɧɚɞ -ɦɿɪɧɨɸ ɦɚɫɨɸ ɬɿɥɚ ɬɚ ɨɠɢɪɿɧɧɹɦ ɧɟ ɜɢɹɜɥɟɧɨ.ɍ ɫɜɨɸ ɱɟɪɝɭ, ɱɚɫɬɨɬɚ ɋ ɚɥɟɥɸ ɜ ɝɪɭɩɿ ɡ ɧɨɪ -ɦɚɥɶɧɨɸ ɦɚɫɨɸ ɬɿɥɚ ɩɪɟɜɚɥɸɽ ɩɨɪɿɜɧɹɧɨ ɡ ɬɚɤɨɸ ɭ ɝɪɭɩɚɯ ɿɡ ɡɚɣɜɨɸ ɜɚɝɨɸ.

Ɍɚɤɢɦ ɱɢɧɨɦ, ɚɧɚɥɿɡ ɪɟɡɭɥɶɬɚɬɿɜ ɝɟɧɨɬɢ -ɩɭɜɚɧɧɹ ɡɚ ɩɨɥɿɦɨɪɮɧɢɦ ɥɨɤɭɫɨɦ ɋ825Ɍ GNB3 ɜɢɹɜɢɜ ɫɬɚɬɢɫɬɢɱɧɨ ɡɧɚɱɭɳɿ ɜɿɞɦɿɧɧɨɫɬɿ ɜ

Ɍ ɚɥɟɥɸ ɡ ɩɿɞɜɢɳɟɧɧɹɦ ɦɚɫɢ ɬɿɥɚ. ɉɪɢ ɩɪɨ -ɜɟɞɟɧɧɿ ɩɨɩɚɪɧɨɝɨ ɩɨɪɿɜɧɹɧɧɹ ɝɪɭɩ ɳɨɞɨ ɪɨɡ -ɩɨɞɿɥɭ ɱɚɫɬɨɬ ɝɟɧɨɬɢɩɿɜ, ɜɫɬɚɧɨɜɥɟɧɨ ɫɬɚɬɢɫ -ɬɢɱɧɨ ɡɧɚɱɭɳɭ ɪɿɡɧɢɰɸ ɦɿɠ I ɬɚ II, I ɬɚ III, II ɬɚ III ɝɪɭɩɚɦɢ (ɪ<0,001, p<0,001, p<0,001 ɜɿɞ -ɩɨɜɿɞɧɨ,ɡɚ Ɇɚɧɧɨɦ-ɍɿɬɧɿ).

Ɋɟɡɭɥɶɬɚɬɢ ɚɧɚɥɿɡɭ ɪɢɡɢɤɭ ɜɢɧɢɤɧɟɧɧɹ ɨɠɢ -ɪɿɧɧɹ ɬɚ ɧɚɞɦɿɪɧɨʀ ɦɚɫɢ ɬɿɥɚ ɭ ɯɜɨɪɢɯ ɧɚ ȺȽ ɡɚɥɟɠɧɨ ɜɿɞ ɋ825Ɍ ɩɨɥɿɦɨɪɮɿɡɦɭ ɝɟɧɚ GNB3 ɩɪɟɞɫɬɚɜɥɟɧɿ ɜ ɬɚɛɥɢɰɿ 2.

Ⱥɧɚɥɿɡ ɪɢɡɢɤɭ ɜɢɧɢɤɧɟɧɧɹ ɨɠɢɪɿɧɧɹ ɬɚ ɧɚɞɦɿɪɧɨʀ ɦɚɫɢ ɬɿɥɚ ɭ ɯɜɨɪɢɯ

ɧɚ ɚɪɬɟɪɿɚɥɶɧɭ ɝɿɩɟɪɬɟɧɡɿɸ ɡɚɥɟɠɧɨ ɜɿɞ ɋ

825 Ɍ ɩɨɥɿɦɨɪɮɿɡɦɭ ɝɟɧɚ

GNB3

95% Ⱦȱ

Ⱥɥɟɥɿ ɪ ȼɒ

ɧɢɠɧɹ ɦɟɠɚ ɜɟɪɯɧɹ ɦɟɠɚ

ɋ 0,45 0,21 0,98

Ɍ

0,04

2,22 1,02 4,83

Ɋɢɡɢɤ ɜɢɧɢɤɧɟɧɧɹ ɨɠɢɪɿɧɧɹ ɬɚ ɧɚɞɦɿɪɧɨʀ ɦɚɫɢ ɬɿɥɚ ɭ ɯɜɨɪɢɯ ɧɚ ȺȽ ɧɨɫɿʀɜ Ɍ ɚɥɟɥɸ ɭ 2,2 ɪɚ -ɡɭ ɜɢɳɢɣ, ɧɿɠ ɭ ɧɨɫɿʀɜ ɋ ɚɥɟɥɸ. ɋɬɚɬɢɫɬɢɱɧɨ ɜɿɪɨɝɿɞɧɿ ɞɚɧɿ ɨɬɪɢɦɚɧɿ ɩɪɢ ɜɢɡɧɚɱɟɧɧɿ ɪɢɡɢɤɭ ɜɢɧɢɤɧɟɧɧɹ ɨɠɢɪɿɧɧɹ ɬɚ ɧɚɞɦɿɪɧɨʀ ɦɚɫɢ ɬɿɥɚ ɭ

ɯɜɨɪɢɯ ɧɚ ȺȽ ɡɚɥɟɠɧɨ ɜɿɞ ɝɟɧɨɬɢɩɭ ɡɚ ɋ825Ɍ ɩɨɥɿɦɨɪɮɿɡɦɨɦ ɝɟɧɚ GNB3.

Ɋɟɡɭɥɶɬɚɬɢ ɚɧɚɥɿɡɭ ɪɢɡɢɤɭ ɜɢɧɢɤɧɟɧɧɹ ɨɠɢ -ɪɿɧɧɹ ɬɚ ɧɚɞɦɿɪɧɨʀ ɦɚɫɢ ɬɿɥɚ ɭ ɯɜɨɪɢɯ ɧɚ ȺȽ ɡɚɥɟɠɧɨ ɜɿɞ ɫɬɚɬɿ ɩɪɟɞɫɬɚɜɥɟɧɿ ɜ ɬɚɛɥɢɰɿ 3.

Ⱥɧɚɥɿɡ ɪɢɡɢɤɭ ɜɢɧɢɤɧɟɧɧɹ ɨɠɢɪɿɧɧɹ ɬɚ ɧɚɞɦɿɪɧɨʀ ɦɚɫɢ ɬɿɥɚ

ɭ ɯɜɨɪɢɯ ɧɚ ɚɪɬɟɪɿɚɥɶɧɭ ɝɿɩɟɪɬɟɧɡɿɸ ɡɚɥɟɠɧɨ ɜɿɞ ɫɬɚɬɬɿ

95% Ⱦȱ

ɋɬɚɬɶ ɪ ȼɒ

ɑɨɥɨɜɿɤɢ 1,023 0,74 1,42

ɀɿɧɤɢ 0,89 0,970 0,63 1,5

Ɋɢɡɢɤ ɜɢɧɢɤɧɟɧɧɹ ɨɠɢɪɿɧɧɹ ɬɚ ɧɚɞɦɿɪɧɨʀ ɦɚɫɢ ɬɿɥɚ ɭ ɯɜɨɪɢɯ ɧɚ ȺȽ ɡɚɥɟɠɧɨ ɜɿɞ ɫɬɚɬɬɿ ɜɢɹɜɢɜɫɹ ɫɬɚɬɢɫɬɢɱɧɨ ɧɟ ɜɿɪɨɝɿɞɧɢɦ (ɪ=0,89).

Ⱦɚɧɿ ɩɪɨɜɟɞɟɧɨɝɨ ɚɧɚɥɿɡɭ ɪɢɡɢɤɭ ɜɢɧɢɤɧɟɧɧɹ ȺȽ ɡɚɥɟɠɧɨ ɜɿɞ ɝɟɧɨɬɢɩɭ ɡɚ ɋ825Ɍ ɩɨɥɿɦɨɪ -ɮɿɡɦɨɦ ɝɟɧɚ GNB3 ɭ ɩɚɰɿɽɧɬɿɜ ɿɡ ɪɿɡɧɢɦ ȱɆɌ ɩɪɟɞɫɬɚɜɥɟɧɿ ɜ ɬɚɛɥɢɰɿ 4.

ȼɿɪɨɝɿɞɧɢɯ ɜɿɞɦɿɧɧɨɫɬɟɣ ɳɨɞɨ ɡɪɨɫɬɚɧɧɹ ɪɢɡɢɤɭ ɜɢɧɢɤɧɟɧɧɹ ȺȽ ɭ ɧɨɫɿʀɜ Ɍ ɚɥɟɥɸ ɜ I ɝɪɭɩɿ ɧɟ ɜɢɹɜɥɟɧɨ (ɪ=0,19), ɬɨɞɿ ɹɤ ɭ ɩɚɰɿɽɧɬɿɜ ɡ ɧɚɞɦɿɪɧɨɸ ɦɚɫɨɸ ɬɿɥɚ ɬɚ ɨɠɢɪɿɧɧɹɦ ɪɢɡɢɤ

ɜɢɧɢɤɧɟɧɧɹ ȺȽ ɡɛɿɥɶɲɭɽɬɶɫɹ ɭ 2 ɬɚ 2,3 ɪɚɡɭ ɜɿɞɩɨɜɿɞɧɨ (ɪ=0,03ɬɚ ɪ=0,003 ɜɿɞɩɨɜɿɞɧɨ).

(5)

ɄɅȱɇȱɑɇȺ ɆȿȾɂɐɂɇȺ

0,877 ɬɚ 0,909 ɭ ɠɢɬɟɥɿɜ Ⱥɮɪɢɤɢ [16]. ɇɚɲɿ ɪɟɡɭɥɶɬɚɬɢ ɬɚɤɨɠ ɩɪɨɞɟɦɨɧɫɬɪɭɜɚɥɢ ɜɿɪɨɝɿɞɧɨ ɜɢɳɭ ɱɚɫɬɨɬɭ Ɍ ɚɥɟɥɸ ɭ ɯɜɨɪɢɯ ɡ ɧɚɞɦɿɪɧɨɸ ɦɚɫɨɸ ɬɿɥɚ ɬɚ ɨɠɢɪɿɧɧɹɦ ɩɨɪɿɜɧɹɧɨ ɿɡ ɯɜɨɪɢɦɢ ɡ ɧɨɪɦɚɥɶɧɨɸ ɦɚɫɨɸ ɬɿɥɚ.

Ⱦɨɫɥɿɞɠɟɧɧɹ ɱɚɫɬɨɬɢ ɝɟɧɨɬɢɩɿɜ ɡɚ ɋ825Ɍ ɩɨɥɿɦɨɪɮɿɡɦɨɦ ɝɟɧɚ GNB3 ɭ ɠɿɧɨɤ ɿɡ ɡɚɣɜɨɸ

ɜɚɝɨɸ ɩɨɤɚɡɚɥɨ ɚɫɨɰɿɚɰɿɸ Ɍ ɚɥɟɥɸ ɡ ɧɚɞɥɢɲ -ɤɨɜɨɸ ɦɚɫɨɸ ɬɿɥɚ ɬɚ ɨɠɢɪɿɧɧɹɦ [10], ɚɥɟ ɧɚɲɟ ɞɨɫɥɿɞɠɟɧɧɹ ɧɟ ɩɪɨɞɟɦɨɧɫɬɪɭɜɚɥɨ ɡɜ'ɹɡɤɭ ɝɟɧ -ɞɟɪɧɢɯ ɜɿɞɦɿɧɧɨɫɬɟɣ ɡ ɪɢɡɢɤɨɦ ɜɢɧɢɤɧɟɧɧɹ ɨɠɢɪɿɧɧɹ ɬɚ ɧɚɞɦɿɪɧɨʀ ɦɚɫɢ ɬɿɥɚ ɭ ɯɜɨɪɢɯ ɧɚ ȺȽ ɡɚ ɰɢɦ ɩɨɥɿɦɨɪɮɿɡɦɨɦ.

Ⱥɧɚɥɿɡ ɪɢɡɢɤɭ ɜɢɧɢɤɧɟɧɧɹ ɚɪɬɟɪɿɚɥɶɧɨʀ ɝɿɩɟɪɬɟɧɡɿʀ ɡɚɥɟɠɧɨ

ɜɿɞ ɋ

825 Ɍ ɩɨɥɿɦɨɪɮɿɡɦɭ ɝɟɧɚ

GNB3

ɭ ɩɚɰɿɽɧɬɿɜ ɡ ɪɿɡɧɢɦ ɿɧɞɟɤɫɨɦ ɦɚɫɢ ɬɿɥɚ

95% Ⱦȱ

Ƚɪɭɩɢ Ⱥɥɟɥɶ ɪ ȼɒ

ɋ 0,64 0,33 1,25

ȱ

Ɍ

0,19

1,57 0,8 3,06

ɋ 0,48 0,25 0,92

ȱȱ

Ɍ

0,03

2,07 1,09 3,93

ɋ 0,44 0,25 0,76

ȱȱȱ

Ɍ

0,003

2,29 1,32 3,96

ɇɟ ɞɨɜɟɞɟɧɨ ɚɫɨɰɿɚɰɿɸ Ɍ ɚɥɟɥɸ ɿɡ ɡɚɣɜɨɸ ɜɚɝɨɸ ɜ ɩɨɩɭɥɹɰɿʀ ɤɢɬɚɣɰɿɜ, ɡɚ ɹɤɢɦɢ ɱɚɫɬɨɬɚ ɋ ɬɚ Ɍ ɚɥɟɥɿɜ ɜ ɝɪɭɩɚɯ ɡ ɧɨɪɦɚɥɶɧɨɸ ɦɚɫɨɸ ɬɿɥɚ ɬɚ ɨɠɢɪɿɧɧɹɦ ɫɬɚɧɨɜɢɥɚ 0,528 ɬɚ 0,472, 0,531 ɬɚ 0,469 ɜɿɞɩɨɜɿɞɧɨ [7, 9]. ɉɪɨɬɟ ɡɚ ɪɟɡɭɥɶɬɚɬɚɦɢ ɧɚɲɨɝɨ ɞɨɫɥɿɞɠɟɧɧɹ ɱɚɫɬɨɬɚ Ɍ ɚɥɟɥɸ ɜ ɝɪɭɩɿ ɯɜɨɪɢɯ ɧɚ ȺȽ ɡ ɨɠɢɪɿɧɧɹɦ ɭ 3 ɪɚɡɢ ɜɢɳɚ ɡɚ ɱɚɫɬɨɬɭ ɋ ɚɥɟɥɸ (0,732 ɬɚ 0,268 ɜɿɞɩɨɜɿɞɧɨ), ɚ ɪɢɡɢɤ ɜɢɧɢɤɧɟɧɧɹ ɨɠɢɪɿɧɧɹ ɬɚ ɧɚɞɦɿɪɧɨʀ ɦɚɫɢ ɬɿɥɚ ɭ ɯɜɨɪɢɯ ɧɚ ȺȽ ɡɚ ɰɢɦ ɩɨɥɿɦɨɪɮɿɡɦɨɦ ɜɢɳɢɣ ɭ ɧɨɫɿʀɜ Ɍ ɚɥɟɥɸ.

Ɉɬɠɟ, ɪɟɡɭɥɶɬɚɬɢ ɧɚɲɨɝɨ ɞɨɫɥɿɞɠɟɧɧɹ ɞɨ -ɜɨɞɹɬɶ ɚɫɨɰɿɚɰɿɸ ɋ825Ɍ ɩɨɥɿɦɨɪɮɿɡɦɭ ɝɟɧɚ GNB3 ɬɚ ɡɚɣɜɨʀ ɜɚɝɢ, ɳɨ ɫɩɿɜɡɜɭɱɧɨ ɡ ɪɟɡɭɥɶ -ɬɚɬɚɦɢ ɩɟɪɟɜɚɠɧɨʀ ɛɿɥɶɲɨɫɬɿ ɞɨɫɥɿɞɧɢɤɿɜ.

ȼɂɋɇɈȼɄɂ

1. ȼɢɹɜɥɟɧɨ ɫɬɚɬɢɫɬɢɱɧɨ ɜɿɪɨɝɿɞɧɟ ɡɛɿɥɶɲɟɧɧɹ ɱɚɫɬɨɬɢ ɝɟɧɨɬɢɩɿɜ ɋ/Ɍ, Ɍ/Ɍ ɬɚ Ɍ ɚɥɟɥɸ ɭ ɩɚɰɿɽɧ -ɬɿɜ ɡ ȺȽ ɬɚ ɧɚɞɦɿɪɧɨɸ ɦɚɫɨɸ ɬɿɥɚ ɬɚ ɨɠɢɪɿɧɧɹɦ ɩɨɪɿɜɧɹɧɨ ɡ ɩɚɰɿɽɧɬɚɦɢ ɡ ɧɨɪɦɚɥɶɧɨɸ ɦɚɫɨɸ ɬɿɥɚ, ɳɨ ɩɿɞɬɜɟɪɞɠɭɽ ɚɫɨɰɿɚɰɿɸ Ɍ ɚɥɟɥɸ ɝɟɧɚ GNB3 ɡɿ ɫɯɢɥɶɧɿɫɬɸ ɞɨ ɨɠɢɪɿɧɧɹ ɬɚ ɧɚɞɦɿɪɧɨʀ ɦɚɫɢ ɬɿɥɚ.

2. Ɋɢɡɢɤ ɜɢɧɢɤɧɟɧɧɹ ɨɠɢɪɿɧɧɹ ɬɚ ɧɚɞɦɿɪɧɨʀ ɦɚɫɢ ɬɿɥɚ ɭ ɯɜɨɪɢɯ ɧɚ ȺȽ ɭ ɧɨɫɿʀɜ Ɍ ɚɥɟɥɸ ɜ 2,2 ɪɚɡɭ ɜɢɳɢɣ,ɧɿɠ ɭ ɧɨɫɿʀɜ ɋ ɚɥɟɥɸ.

3. Ɋɢɡɢɤ ɜɢɧɢɤɧɟɧɧɹ ȺȽ ɭ ɧɨɫɿʀɜ Ɍ ɚɥɟɥɸ ɡ ɧɚɞɦɿɪɧɨɸ ɦɚɫɨɸ ɬɿɥɚ ɬɚ ɨɠɢɪɿɧɧɹɦ ɜɿɪɨɝɿɞɧɨ ɜɢɳɢɣ ɩɨɪɿɜɧɹɧɨ ɿɡ ɯɜɨɪɢɦɢ ɡ ɧɨɪɦɚɥɶɧɨɸ ɦɚɫɨɸ ɬɿɥɚ.

ɋ

ɉ

ɂ

ɋ

Ɉ

Ʉ

Ʌ

ȱ

Ɍ

ȿ

Ɋ

Ⱥ

Ɍ

ɍ

Ɋ

ɂ

1. Ƚɨɪɛɚɫɶ ȱ.Ɇ. ɉɪɨɝɪɚɦɚ ɩɪɨɮɿɥɚɤɬɢɤɢ ɬɚ ɥɿɤɭɜɚɧɧɹ ɚɪɬɟɪɿɚɥɶɧɨʀ ɝɿɩɟɪɬɟɧɡɿʀ ɜ ɍɤɪɚʀɧɿ:ɩɿɞɫɭɦɤɢ ɜɢɤɨɧɚɧɧɹ / ȱ.Ɇ.Ƚɨɪɛɚɫɶ // Ɂɞɨɪɨɜ’ɹ ɍɤɪɚʀɧɢ. – 2011.– ʋ 3 (18).– ɋ.32í34.

2. Ʌɭɩɚɧɨɜ ȼ.ɉ.Ɉɠɢɪɟɧɢɟ ɤɚɤ ɮɚɤɬɨɪ ɪɢɫɤɚ ɪɚɡ -ɜɢɬɢɹ ɫɟɪɞɟɱɧɨ-ɫɨɫɭɞɢɫɬɵɯ ɤɚɬɚɫɬɪɨɮ / ȼ.ɉ.Ʌɭɩɚɧɨɜ //Ɋɨɫ.ɦɟɞ.ɠɭɪɧɚɥ. — 2003. — Ɍ. 11, ʋ 6. – ɋ. 331-337.

3. ɉɚɧɶɤɿɜ ȼ.ȱ. Ɉɠɢɪɿɧɧɹ ɹɤ ɦɟɞɢɤɨ-ɫɨɰɿɚɥɶɧɚ ɩɪɨɛɥɟɦɚ / ȼ.ȱ ɉɚɧɶɤɿɜ // ɉɪɚɤɬɢɱɧɚ ɚɧɝɿɨɥɨɝɿɹ. – 2006. í ʋ 5. – ɋ. 27 – 32.

4. Ɋɟɛɪɨɜɚ Ɉ.ɘ. ɋɬɚɬɢɫɬɢɱɟɫɤɢɣ ɚɧɚɥɢɡ

ɦɟɞɢ-ɩɪɨɝɪɚɦɦ STATISTICA / Ɉ.ɘ.Ɋɟɛɪɨɜɚ. – Ɇ.: Ɇɟɞɢɚɋɮɟɪɚ, 2002. – 312 ɫ.

5. Ɋɟɤɨɦɟɧɞɚɰɿʀ ɍɤɪɚʀɧɫɶɤɨʀ ɚɫɨɰɿɚɰɿʀ ɤɚɪɞɿɨɥɨɝɿɜ ɡ ɩɪɨɮɿɥɚɤɬɢɤɢ ɬɚ ɥɿɤɭɜɚɧɧɹ ɚɪɬɟɪɿɚɥɶɧɨʀ ɝɿɩɟɪɬɟɧɡɿʀ: ɩɨɫɿɛ. ɞɨ ɇɚɰ. ɩɪɨɝɪɚɦɢ ɩɪɨɮɿɥɚɤɬɢɤɢ ɿ ɥɿɤɭɜɚɧɧɹ ɚɪɬɟɪɿɚɥɶɧɨʀ ɝɿɩɟɪɬɟɧɡɿʀ. – 4-ɟ ɜɢɞ., ɜɢɩɪ. ɿ ɞɨɩ. / ȯ.ɉ.ɋɜɿɳɟɧɤɨ,Ⱥ.ȯ.Ȼɚɝɪɿɣ, Ʌ.Ɇ.ȯɧɚ [ɬɚ ɿɧ.] // Ⱥɪɬɟ-ɪɢɚɥɶɧɚɹ ɝɢɩɟɪɬɟɧɡɢɹ. – 2009. í ʋ 1(3).

(6)

15/

Ɍɨɦ

XX / 3

N 6. – Ɋ. 670í674.

8. Andrew J. Walley. Genetics of obesity and the predic-tion of risk for health / A.J. Walley, I.F. Blakemore, Ph. Fro-guel // Hum. Mol. Genet.í2006. – Vol. 15, N 2. – P. 124í130. 9. Association of the C825T polymorphism in the GNB3 gene with obesity and metabolic phenotypes in a Taiwanese population / T.J. Hsiao, Y. Hwang, C.H. Liu [et al.] // Genes Nutr. – 2013. – Vol. 8, N 1. – Ɋ. 137í144.

10. Effect of the G-protein ȕ3 subunit 825T allele on the change of body adiposity in obese female / I.C. Hwang, K.K. Kim, H.Y. Ahn [et al.] // Diabetes Obes Metab. – 2013. – Vol. 15, N 3. – Ɋ. 284í286.

11. Glucose and lipid metabolism in young lean normotensive males with the G protein beta3 825T-allele / B. Saller, P. Nemesszeghy, K. Mann [et al.] // Eur. J. Med. Res. – 2003. – Vol. 3 – N 8. – P. 91í97.

12. Hypertension, obesity and GNB3 gene variants / M. Danoviz, E. Maria, C. Pereira [et al.] // Clin. Exp. Pharmacol. Physiol. – 2006. – Vol. 33. – P. 248-252.

Res. – 2004. – Vol. 1, N 12. – P. 4í8.

14. Siffert W. G protein B3 subunit 825T allele and hypertension / W. Siffert // Cur. Hypertens. Rep. í 2003. í Vol. 1, N5. í P. 47í53.

15. Siffert W. Genetic polymorphism of the G-protein beta3 subunit, obesity and essential hypertension / W. Siffert, D. Rosskopf, R. Erbel // Herz. – 2000. – Vol. 25, N 1. – P. – 26í33.

16. Siffert W. Worldwide ethnic distribution of the G-protein beta3 subunit 825T allele and its association with obesity in ɫaucasion, ɫhinese and ɜlack ɚfrican indi-viduals / W. Siffert // J. Am. Soc. Nephrol. – 1999. – N10. –Ɋ. 1921í1930.

17. Study on the Correlativity between G-protein b3 Subunit Gene C825T Genotype and Obesity / A. Guter-sohn, C. Naber, N. Müller [et al.] // Lancet. – 2000. – N 355. – P. 1240-1241.

R

E

F

E

R

E

N

C

E

S

1. Gorbas' IM. [The program for prevention and treatment of hypertension in Ukraine: results of performance]. Zdorov’ja Ukrai'ny. 2011;3(18):32í34. Ukrainian.

2. Lupanov VP. [Obesity as a risk factor for car-diovascular events]. Ros. med. zhurnal. 2003;11.(6):331-7. Russian.

3. Pan'kiv VI. [Obesity as a medical and social problem]. Praktychna angiologija.2006;5:27-32. Uk-rainian.

4. Rebrova OYu. [Statistical analysis of medical data. The use of the application package STATISTICA.]. M., MediaSfera 2002;312. Russian.

5. Svɿshchenko ȯP, Bagrɿy Aȯ, Yena LM, et al. [Recommendations of Ukrainian Association of Cardiology on prevention and treatment of hypertension. Guide to the National program for prevention and treatment of hypertension. Fourth edition, revised and expanded]. Arterial'naya gipertenziya. 2009;1(3). Ukrainian.

6. Chazova YE. [4 years and 7796 patients: pos-sibility of full dose combination therapy of hypertension]. Systemnaja gypertenzyja. 2008;1:4í9. Russian.

7. Wang X, Bai H, Fan P, et al. Analysis of the GNB3 gene 825C/T polymorphism in non-obese and obese Chinese Chin. J. Med. Gen. 2008;25(6):670í4.

8. Andrew J Walley, Blakemore IF, Froguel Ph. Genetics of obesity and the prediction of risk for health. Hum. Mol. Genet. 2006;15(2):124í30.

9. Hsiao TJ, Hwang Y, Liu CH, et al. Association of the C825T polymorphism in the GNB3 gene with obesity

and metabolic phenotypes in a Taiwanese population . Genes Nutr. 2013;8(1):137í44.

10. Hwang IC, Kim KK, Ahn HY, et al. Effect of the G-protein ȕ3 subunit 825T allele on the change of body adiposity in obese female. Diabetes Obes Metab. 2013;15(3): 284í6

11. Saller B, Nemesszeghy P, Mann K, Siffert W, Rosskopf D. Glucose and lipid metabolism in young lean normotensive males with the G protein beta3 825T-allele. Eur. J. Med. Res.2003;3(8).91í97.

12. Danoviz M, Maria E, Pereira C, et al. Hyper-tension, obesity and GNB3 gene variants. Clin. Exp. Pharmacol. Physiol.2006;33:248í52.

13. Suwazono Y, Okubo Y, Kobayashi E, et al. Lack of Association between Human G-Protein ȕ3 Subunit Variant and Overweight in Japanese Workers. Obes. Res. 2004;1(12).4í8.

14. Siffert W. G protein B3 subunit 825T allele and hypertension Cur. Hypertens. Rep. 2003;1(5):47í53.

15. Siffert W, Rosskopf D, Erbel R. Genetic poly-morphism of the G-protein beta3 subunit, obesity and essential hypertension. Herz.2000;1(25):26í33.

16. Siffert W. Worldwide ethnic distribution of the G-protein beta3 subunit 825T allele and its association with obesity in ɫaucasion, ɫhinese and ɜlack ɚfrican indi-viduals J. Am. Soc. Nephrol.1999;10:1921í30.

17. Gutersohn A, Naber C, Müller N, et al. Study on the Correlativity between G-protein b3 Subunit Gene C825T Genotype and Obesity. Lancet.2000;55:1240í1.