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Lysophosphatidic acid activates peroxisome proliferator activated receptor-γ in CHO cells that over-express glycerol 3-phosphate acyltransferase-1.

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Academic year: 2017

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Figure 1. Pathway of glycerolipid synthesis. AGPAT, acyl-glycerol- acyl-glycerol-3-phosphate acyltransferase; CL, cardiolipin; DGK, diacylglycerol kinase;
Table 1. Overexpression of GPAT1 in CHO cells increased intracellular levels of LPA, and lowered the content of acyl-CoA and DAG.
Figure 2. Overexpression of GPAT1 in CHO cells activated PPARc. (A) CHO and CHO-GPAT1 cells were transfected with 0.1 mg of pRLSV40 (internal LUC control) and equal concentrations (0.4 mg) of a PPARc expression vector, an RXR expression vector, and a PPRE-
Table 2. LPA and PA displace [ 3 H]rosiglitazone from PPARc- PPARc-LBD. Glycerolipid species Percent displacement of[3H]rosiglitazone sn -1-18:0-LPA 25.961.5 sn -1-16:0-LPA 29.661.2 sn-1, 2-di18:1-PA 24.2 6 0.8 sn -1-16:0, 2-18:1-PA 21.760.9
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