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mTORC1 is essential for early steps during Schwann cell differentiation of amniotic fluid stem cells and regulates lipogenic gene expression.

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Academic year: 2017

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Figure 2. Human monoclonal amniotic fluid stem cells can be differentiated into a early Schwann cell phenotype
Figure 4. Rapamycin treatment down-regulates Schwann cell marker expression in differentiated human AFS cells and in sciatic nerves from juvenile mice
Figure 7. Model of mTORC1 involvement in Schwann cell differentiation. Rapamycin blocks mTORC1 and results in the down regulation of Schwann cell markers (e.g.: S100b) and in the down regulation of lipogenic genes (e.g.: LDLR, HMGCR)

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