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A cysteine protease inhibitor of plasmodium berghei is essential for exo-erythrocytic development.

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Figure 1. PbICP is not essential for parasite blood stage development. (A) Assessment of SSR at the pbicp locus in pbicp-transgenic parasites (PbICP cond , PbICP KO , and PbICP comp ) by PCR of genomic DNA using primers P1 and P3 (see Figure S1)
Figure 3. PbICP is important for effective invasion of and development within hepatocytes
Figure 4. Morphological differences in PbICP cond EEF development. IFA of HepG2 cells infected with either PbICP control (control), PbICP cond
Figure 5. PbICP is Important for EEF Maturation. (A) IFA of infected, detached cells 65 hpi (mature EEFs) of either PbICP control (first panel), PbICP cond (second panel), or PbICP comp (third panel) parasites

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