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Endocrinol Metab 2013;28:155-156
http://dx.doi.org/10.3803/EnM.2013.28.2.155 pISSN 2093-596X · eISSN 2093-5978
Response
The Relationship of Body Composition and Coronary
Artery Calcification in Apparently Healthy Korean Adults
(
Endocrinol Metab
2013;28:33-40, Jung-Hee Yu et al.)
Jung-Hee Yu, Eun-Jung Rhee
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
We want to thank the editors of Endocrinology and Metabo-lism for giving us the opportunity to publish our work in En-docrinology and Metabolism and also for the insightful com-ments on our paper. There have been a few previous studies performed on the association between body composition and coronary artery calcification in other ethnic groups [1-3], how-ever, as the editors commented, our work is valuable in that this was the first study of its kind performed in apparently healthy Korean adults. Given that more and more interest has been shown on the differential effects of various proportions of lean mass and fat mass on metabolism, our study is mean-ingful in that we confirmed the importance of visceral fat, not only in development of insulin resistance, but also in subclini-cal atherosclerosis in the Korean population.
Regarding the comments from Prof. Choi, we performed logistic regression analyses with coronary artery calcification as the dependent variable, after adjusting for confounding fac-tors including the lean and fat mass separately for men and women. However, when logistic regression analyses were per-formed separately for the different genders, only age showed a significant correlation with coronary artery calcification, after adjusting for all the confounding variables in either gender. We do not know why the analyses separated by gender showed different results from the analyses of the total population;
how-ever, the decreased number of patients in the separate study populations could have weakened the significance of the cor-relation that had been observed in the analyses of the whole study population. In addition, failure to consider the subjects’ medical history, especially the medication use, could have af-fected the confounding variables included in the model, since the proportion of medication use could have been different in each gender. As Prof. Choi referred, the absence of subjects’ personal medication and disease history, which is the weakest point of this study, could have affected the main results.
CONFLICTS OF INTEREST
No potential conflict of interest relevant to this article was re-ported.
REFERENCES
1. Lee CD, Jacobs DR Jr, Schreiner PJ, Iribarren C, Hankin-son A. Abdominal obesity and coronary artery calcification in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am J Clin Nutr 2007;86: 48-54.
2. Ohashi N, Yamamoto H, Horiguchi J, Kitagawa T, Hirai N,
Corresponding author: Eun-Jung Rhee
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 110-746, Korea
Tel: +82-2-2001-2485, Fax: +82-2-2001-1588, E-mail: hongsiri@hanmail.net
Copyright © 2013 Korean Endocrine Society
Yu JH, et al.
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www.e-enm.org Copyright © 2013 Korean Endocrine SocietyIto K, Kohno N. Visceral fat accumulation as a predictor of coronary artery calcium as assessed by multislice comput-ed tomography in Japanese patients. Atherosclerosis 2009; 202:192-9.
