Alterations of the gastric stump and not resected stomach mucosa after truncal vagotomy in rats

Alterations of the gastric stump and not resected stomach mucosa

after truncal vagotomy in rats

Paulo Antônio RodriguesI_{, Luiz Eduardo Naresse}II_{, José Guilherme Minossi}III_{, Claudia Nishida Hasimoto}IV

I_{PhD, Assistant Professor, Departament of Surgery & Orthopedics, Faculty of Medicine, Sao Paulo State University (UNESP), Botucatu-SP, Brazil.} &RQFHSWLRQGHVLJQLQWHOOHFWXDODQGVFLHQWL¿FFRQWHQWRIWKHVWXG\DFTXLVLWLRQDQGLQWHUSUHWDWLRQRIGDWDWHFKQLFDOSURFHGXUHVPDQXVFULSWZULWLQJ II_{PhD, Associate Professor, Departament of Surgery & Orthopedics, Faculty of Medicine, UNESP, Botucatu-SP, Brazil. Interpretation of data,}

technical procedures.

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interpretation of data.

ABSTRACT

PURPOSE: To evaluate morphological changes of the gastric stump and not resected stomach mucosa after the completion of truncal vagotomy.

METHODS: (LJKW\PDOH:LVWDUUDWVZHUHGLYLGHGLQWRIRXUJURXSV&7795<DQG5<79,Q&7JURXSDEGRPLQDOYLVFHUDZHUH PDQLSXODWHGDQGWKHDEGRPLQDOFDYLW\ZDVFORVHGLQ79YDJDOWUXQNVZHUHLVRODWHGDQGVHFWLRQHGLQ5<DSDUWLDO5RX[HQ<JDVWUHFWRP\ ZDVSHUIRUPHGDQGLQ5<79WKHYDJDOWUXQNVZHUHVHFWLRQHGDQGDSDUWLDO5RX[HQ<JDVWUHFWRP\ZDVSHUIRUPHG$WWKHWKZHHN DIWHUVXUJHU\WKHUDWVZHUHHXWKDQL]HG7KH¿QGLQJVZHUHVXEPLWWHGWRKLVWRORJLFDODQDO\VHV

RESULTS: 1RQHPDFURVFRSLFRUKLVWRORJLFDODOWHUDWLRQVLQJURXSV79DQG&7ZDVREVHUYHG6SHFLPHQVIURP5<DQG5<79JURXSV GLGQRWVKRZDOWHUDWLRQVLQWKHJDVWULFVWXPSPXFRVD$WWKHMHMXQDOVLGHRIWKHJDVWURHQWHURVWRP\ZHIRXQGVKDOORZXOFHUDWLYHOHVLRQV DOZD\VVLQJOHZHOOGH¿QHGDQGZLWKYDULDEOHGLDPHWHUWRPPVL[WLPHVLQWKH5<JURXSDQGQRQHLQWKH5<79JURXS5<!5<79 S 1HRSODVWLFRUSUHQHRSODVWLFOHVLRQVZHUHQRWGLDJQRVHGLQDOOJURXSV

CONCLUSION: Truncal vagotomy is a safe and non-carcinogenic method in not resected and partially resected stomach.

Key words: 9DJRWRP\7UXQFDO$GHQRFDUFLQRPD6WRPDFK5DWV

Introduction

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secretions from the gastroenterostomy and therefore damaging the

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factor for the development of gastric cancer in epidemiological

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to a decrease in the gastric mucosa cell function, cytoprotection, and an increase in regeneration of immature cells8_.

Methods

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Control (CT): XQGHUZHQW WR ODSDURWRP\ DQG PDQLSXODWLRQRIWKHDEGRPLQDOYLVFHUD

Truncal vagotomy (TV): XQGHUZHQW WR VHFWLRQ RI WKH DQWHULRUDQGSRVWHULRUYDJDOWUXQNV

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Roux-en-Y + Truncal Vagotomy (RYTV):XQGHUZHQW WR WKH VDPH VXUJLFDO SURFHGXUH RI JURXS 5< DGGLQJ ELODWHUDO

truncal vagotomy.

In all surgical procedures, animals received anesthesia

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procedures is illustrated in Figure 1.

FIGURE 1 - Schematic representation of the surgical procedures.

After the surgical procedure, the animals had access

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to it one. We used conventional methods for the preparation of

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portion and in the gastric stump mucosa. The general appearance

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Discussion

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causes a decrease in the release of hormones such as secretin

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surgery, the chlorydropeptic secretion produced in the gastric

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effective in preventing the development of gastroenterostomy

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truncal vagotomy,QWKHSUHVHQWVWXG\LWZDVQRWREVHUYHGWKH

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mention that truncal vagotomy has the potential to facilitate the development of such lesions. Truncal vagotomy causes several

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the stomach to secrete hydrochloric acid causing an increase in

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N-nitroso compounds 79 PD\ DOVR FKDQJH WKH SHUPHDELOLW\ of the mucosa of the stomach due to decreased in secretion of

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proliferative compartment of gastric epithelium.

Some epidemiological studies suggest that vagotomy

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denervation of the gastric mucosa not only leads to decreased

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increases the regeneration of immature cells8,18_.

Conclusion

Truncal vagotomy is a safe and effective method in not resected and partially resected stomach, since it prevents the development of anastomotic ulcers and does not causes the development of lesions considered preneoplastic or neoplastic.

References

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troncular vagotomy modify the proliferative gastric lesions induced

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Acknowledgement

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the study, formatting and proofreading the manuscript in English.

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