DOI: 10.18410/jebmh/2015/607
ORIGINAL ARTICLE
J of Evidence Based Med & Hlthcare, pISSN- 2349-2562, eISSN- 2349-2570/ Vol. 2/Issue 29/July 20, 2015 Page 4292
FAMILIAL TENDENCIES OF ENDOMETRIOSIS: A CROSS SECTIONAL
STUDY
Cooly Vijayalakshmi1, K. Mythili2
HOW TO CITE THIS ARTICLE:
Cooly Vijayalakshmi, K. Mythili. ”Familial Tendencies of Endometriosis: A Cross Sectional Study”. Journal of Evidence based Medicine and Healthcare; Volume 2, Issue 29, July 20, 2015; Page: 4292-4295,
DOI: 10.18410/jebmh/2015/607
ABSTARCT: Endometriosis is most common disease in the reproductive age group. The aim of our study is to known prevalence of endometriosis among first-, second-, and third-degree relatives in a group of patients with varying symptoms related to endometriosis undergoing diagnostic laparoscopy. We analyzed the prevalence of endometriosis among first-, second-, and third-degree relatives in a group of patients with varying symptoms related to endometriosis under-going diagnostic laparoscopy. METHODS: Eighty Six Patients with varying symptoms related to endometriosis undergoing laparoscopy were enrolled. Patients were evaluated about presence of symptoms of endometriosis such as chronic pelvic pain, infertility, and dysmenorrhea in all first-degree relatives (i.e., mother, sisters, and daughters), as well as in all second- and third-degree relatives (aunts, cousins). RESULTS: Mean age of the patient was 29.22±4.28 years. The complaints of the patients were in the order of pelvic pain (86/86, 100%)> dysmenorrhea (76/86, 89%) >dyspareunia (51/86, 60%) >infertility (26/86, 30%). We found that 30.24% of 1st degree relatives, 10.47% of 2nd degree, 1.16% of 3rd degree and 2.33% of combination of 1st and 2nd degree relatives having familial patterns. CONCLUSION: there is a good association of familial endometriosis and symptoms in first degree family members than the other family relatives.
KEYWORDS: familial endometriosis, First degree relatives, Second degree relatives, Third degree relatives, Family history of endometriosis.
INTRODUCTION: Endometriosis is one the benign disease condition of the female reproductive system. It is characterized by endometrial tissue which contains of glandular and stroma, found external to the uterine cavity. Even though implanted ectopically, this tissue presents physiologically and histo-pathologically and responses, similar to the responses of the endometrium.(1) The endometriosis often presents clinically with severe pelvic pain, other
symptoms like dysmenorrhea, dyspareunia and infertility.(2-3) The detailed clinical history,
gynecological examinations, and trans-vaginal ultrasound are the basis for endometriosis.(4-5) Still
the laparoscopy is considered the gold standard diagnostic methods and confirmation by means of histo-pathological assessment.(6) Although a negative result does not rule out the possibility of
the disease.(7) Simpson et al(8) Lamb et al(9) Moen and Mangus et al(10) studies found the
association of endometriosis with first-degree relatives of endometriosis patients. But only a few studies have studied the risk of endometriosis in second- and third-degree relatives.(11) To this
DOI: 10.18410/jebmh/2015/607
ORIGINAL ARTICLE
J of Evidence Based Med & Hlthcare, pISSN- 2349-2562, eISSN- 2349-2570/ Vol. 2/Issue 29/July 20, 2015 Page 4293
METHODS: This cross sectional study was conducted in the department of gynecology, MAPIMS, 86 patients with varying symptoms related to endometriosis undergoing laparoscopy were enrolled between year August 2013 to July 2014. Patients were evaluated about presence of symptoms of endometriosis such as chronic pelvic pain, infertility, and dysmenorrhea in all first-degree relatives (i.e., mother, sisters, and daughters), as well as in all second- and third-first-degree relatives (Aunts, cousins).The maternal and the paternal lines of relatives were evaluated separately. Information about grandmothers was excluded from the study, since reliable information about their medical history could only be provided by a minority of patients.
STATISTICAL ANALYSIS: Data was collected from patients using a questionnaire, entered into excel spread sheet 2007. Data was presented as mean, Standard deviation, actual numbers and percentages.
RESULTS: In the study a total of 86 patients were evaluated. Mean age of the patient was 29.22±4.28 years. The complaints of the patients were in the order of pelvic pain (86/86, 100%)>dysmenorrhea (76/86, 89%)>dyspareunia (51/86, 60%)>infertility (26/86, 30%). We found that 30.24% of 1st degree relatives, 10.47% of 2nd degree, 1.16% of 3rd degree and 2.33% of combination of 1st and 2nd degree relatives having familial patterns. (Table-1)
N=86 % 1st degree relatives
Sister 12 13.95
Mother 9 10.47
Daughter 2 2.33
Mother & sister 3 3.49
Total 26 30.24 2nd degree relatives
Maternal aunt 6 6.98 Paternal aunt 3 3.49
Total 9 10.47 3rd degree relatives
Maternal cousin 1 1.16 Paternal cousin 0 0
Total 1 1.16 Combination of 1st & 2nd degree Sister, Mother and Maternal aunt 2 2.33
Table 1: Family History For Endometriosis
DOI: 10.18410/jebmh/2015/607
ORIGINAL ARTICLE
J of Evidence Based Med & Hlthcare, pISSN- 2349-2562, eISSN- 2349-2570/ Vol. 2/Issue 29/July 20, 2015 Page 4294 Endometriosis associated symptoms in patients with a family history of endometriosis.(12)
In this study, the results were favoring the increased risk of endometriosis in first-degree relatives of endometriosis patients was found. Nouri et al. study supported the theory of genetic predisposition is the only a contributing factor for the development the familial incidence of endometriosis.(13)
CONCLUSION: We found that there is a strong association of familial endometriosis in first degree than the other family relatives. Larger studies are needed to estimate the approximate patterns of family history, such that risk identification, counseling and treatment initiation can be done at the earliest.
REFERENCES:
1. Jansen RP, Russell P. Non-pigmented endometriosis: clinical, laparoscopic, and pathologic definition. Am J Obstet. Gynecol. 1986; 155(6): 1154-9.
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9. Lamb RNK, Hoffmann R, Nichols TR: Family trait analysis: A case-controlstudy of 43 women with endometriosis and their best friends. Am JObstetGynecol 1986, 154: 596-601.
10.Moen MH, Magnus P: The familial risk of endometriosis. Acta Obstet Gynecol Scand 1993, 72: 560-564.
11.Dos Reis RM, de Sá MF, de Moura MD, Nogueira AA, Ribeiro JU, Ramos ES, Ferriani RA: Familial risk among patients with endometriosis. J Assist Reprod Genet 1999, 16: 500-503. 12.Malinak LR, Buttram VC, Elias S, Simpson JL: Heritable aspects ofendometriosis II Clinical
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DOI: 10.18410/jebmh/2015/607
ORIGINAL ARTICLE
J of Evidence Based Med & Hlthcare, pISSN- 2349-2562, eISSN- 2349-2570/ Vol. 2/Issue 29/July 20, 2015 Page 4295
NAME ADDRESS EMAIL ID OF THE CORRESPONDING AUTHOR: Dr. Cooly Vijayalakshmi,
Super Specialty, Rainbow Hospital, Gandhinagar,
Near Saibaba Temple, Nellore-524004.
E-mail: drvijayalakshmi14@yahoo.com
Date of Submission: 16/07/2015. Date of Peer Review: 17/07/2015. Date of Acceptance: 20/07/2015. Date of Publishing: 20/07/2015. AUTHORS:
1. Cooly Vijayalakshmi 2. K. Mythili
PARTICULARS OF CONTRIBUTORS: 1. Associate Professor, Department of
Obstetrics & Gynecology, Melmaruvathur Adhiparashakthi Institute of Medical Sciences. 2. Associate Professor, Department of
