Rodent Model as Tools in Ethical Biomedical Research

(1)

Rodent Model as Tools in Ethical

Biomedical Research

(2)

(3)

Monica Levy Andersen • Sergio Tuﬁ k

Editors

Rodent Model as Tools

in Ethical Biomedical

Research

(4)

ISBN 978-3-319-11577-1 ISBN 978-3-319-11578-8 (eBook) DOI 10.1007/978-3-319-11578-8

Library of Congress Control Number: 2015933848 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016

This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, speciﬁ cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microﬁ lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.

The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a speciﬁ c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.

The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made.

Printed on acid-free paper

Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)

Editors

Monica Levy Andersen Department of Psychobiology Universidade Federal de São Paulo (UNIFESP)

São Paulo , São Paulo , Brazil

Sergio Tuﬁ k

Department of Psychobiology Universidade Federal de São Paulo (UNIFESP)

(5)

v

Pref ace

The objective of this book is to concisely present information with respect to the appropriate use of experimental animals in research. The principles elaborated seek to provide knowledge of the techniques involved in both management and scientiﬁ c research to all who use laboratory animals, with a focus on the well-being and ethics regarding animals. It is also within our scope to fortify the awareness of the impor-tance of the animal as a study object and to offer orientation and assisimpor-tance in con-ducting laboratory research, education, or tests. In this new version, we had the pleasure of working with collaborators from different universities and countries, who signiﬁ cantly contributed to the knowledge and quality of the book. Our most esteemed thanks to all the authors who participated in this book.

São Paulo, Brazil Monica Levy Andersen

(6)

(7)

vii

Acknowledgments

To experimentation animals, who with their lives provide a notable contribution to

the development of new techniques and medical treatments, signifi cantly focusing the advancement of science and bringing benefi ts to human and animal health.

(8)

(9)

ix

Part I Ethics

1 Introduction ... 3 Monica Levy Andersen

2 The Aspects of the Use of Rodents in Experimental Research ... 7 Vera Baumans

3 The Impact of the Environment on Laboratory Animals ... 13 Vera Baumans

4 Care and Maintenance of Laboratory Animals ... 23 Monica Levy Andersen , Vânia D’Almeida , Gui Mi Ko ,

Paulo José Forcina Martins , and Sergio Tuﬁ k

5 Euthanasia ... 39 Monica Levy Andersen and Vera Baumans

Part II Use of Rats

6 The Health of Laboratory Animals ... 53 Monica Levy Andersen , Vânia D’Almeida , Gui Mi Ko ,

Paulo José Forcina Martins , and Sergio Tuﬁ k

7 Rats ... 61 Monica Levy Andersen , Renata Mázaro e Costa ,

and Marcos Fernando Oliveira e Costa

8 The Female Rat ... 95 Isabela Beleza Antunes , Andressa da Silva , Regiane Kawakami ,

and Monica Levy Andersen

About the Editors

Monica Levy Andersen Master in Psychobiology (Universidade Federal de São

Paulo – UNIFESP)

Ph.D. in Psychobiology (Universidade Federal de São Paulo – UNIFESP) Postdoctoral Fellow – Division of Neuroscience Yerkes National Primate Research Center (Emory University), USA

Professor of Division of Sleep at Department of Psychobiology (Universidade Federal de São Paulo – UNIFESP)

Sergio Tufi k Master in Physiology (Universidade Federal de São Paulo – UNIFESP)

Ph.D. in Pharmacology (Universidade Federal de São Paulo – UNIFESP)

Full professor of Division of Sleep at Department of Psychobiology (Universidade Federal de São Paulo – UNIFESP)