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In silico analysis of binding interaction of conantokins with NMDA receptors for potential therapeutic use in Alzheimer ’s disease

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Academic year: 2019

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Fig. 1 a Conserved residues highlighted in conantokins. b Predicted secondary structures of all conantokins aligned
Fig. 2 Validation results for the predicted structure of NMDAR in humans. a Graphical representation of results from ERRAT
Fig. 3 a NMDAR in humans (red) active residues highlighted in green. b NMDAR in rats (blue) residues aligned with residues of NMDAR in humans highlighted in white
Fig. 4 Three-dimensional binding representation of NMDAR (humans) with each conantokin ligand: (1) conantokin Br, (2) conantokin E, (3) conantokin G, (4) conantokin L, (5) conantokin P, (6) conantokin Pr1, (7) conantokin Pr2, (8) conantokin Pr3, (9) conant
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