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Rui Miguel Correia Portela

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Academic year: 2019

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Figure  1.1:  The  theoretical  basis  of  constraint-based  modelling  and  FBA.  a  –   Without  con- con-straints, the hypothetical flux distribution of a biological network can be set anywhere in the  solu-tion space (any combinasolu-tion of metabolic
Figure 2.1: E. coli metabolic network composed by 43 reactions and 24 metabolites. Bold metab- metab-olites  represent  the  ones  that  can  exit  the  system;  these  reactions  are  not  explicit  shown  in  the  scheme
Figure 2.3: Schematic representation of PLS and PLP decomposition operations. Decomposition  of X and Y are similar in PLS and PLP
Table  3.1:  Ranking  of  statistically  significant  EFMs  with  high  correlation  with  the  envirome
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