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Paracrine effects of bone marrow soup restore organ function, regeneration, and repair in salivary glands damaged by irradiation.

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Academic year: 2017

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Figure 1. Bone Marrow Soup re-established saliva secretion following irradiation. A. At week 8 post-irradiation, BM Soup-treated mice (IR+BMSoup) had their salivary flow rate (SFR; ul/min/per g of body weight) restored to normal levels (100%; 0.4 ul/min) w
Figure 3. Role of Bone Marrow Soup in cytoprotection. A. Immunofluorescence staining of specific subpopulations of cells in submandibular glands at 8 wks post-irradiation
Figure 4. Relative gene expression of key factors involved in salivary gland development, repair and regeneration
Figure 7. Levels of key electrolytes in saliva. Electrolytes in saliva (such as sodium, potassium, chloride, and calcium concentration levels) were not different among groups, except for calcium levels (P.0.05; N = 5 to 9 mice per group).

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