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AuPairWise: A Method to Estimate RNA-Seq Replicability through Co-expression.

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Academic year: 2017

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Fig 1. Individual genes have similar expression levels in many tissues. Samples replicate one another to some degree, regardless of the conditions under which they are measured, i.e., whether it is actually a biological replicate or not
Fig 2. Simpson ’ s paradox in expression data. (A) Sample-sample replicability plots are possible for each of the 18 conditions tested
Fig 3. Gene expression replication across the genome. (A) In the reference ENCODE data, many genes are well correlated with their replicate across the range of conditions, but the distribution has a heavy negative tail
Fig 4. Self-correlation (replicability) and co-expression. The degree of correlation between a gene and its replicate is plotted relative to all other genes (relative rank)
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