CURRICULUM VITAE. 4. Main degree(s) Name of university/institute: Universidade Federal do Ceará. 5. Postgraduate education/specialization/training

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CURRICULUM VITAE

1.

Name

Full name:

Ronaldo de Matos Esmeraldo 2.

Academic title

Full title or abbreviation: Mestre em Cirurgia

3.

Present position with full work address

Position:

Head of department of Transplantation of Kidney, Pancreas and Liver. Name of institution or organization:

Hospital Geral de Fortaleza Institution Address:

Rua Ávila Goular, 900 - Prédio Eletivo, 1o andar, Setor de Transplantea, Papicu Telephone:

(55) (85) 3101-3280

Fax:

(55) (85) 3101-3190 City, state & postal/zip code:

Fortaleza, CE / 60156-290

Start date (dd-mmm-yyyy): Dec-2009 - Atual

4. Main degree(s)

Name of university/institute:

Universidade Federal do Ceará

Degree awarded: Medicine City, state & country:

Fortaleza, CE. Brasil

Year of graduation: 1979

5. Postgraduate education/specialization/training

Name of university/institute: Qualification: Dates of attendance:

Hospital dos Servidores do Estado Rio de Janeiro, RJ. Brasil

General Surgery Intern March, 1980 to Febuary, 1981 Hospital de Ipanema

Rio de Janeiro, RJ. Brasil

General Surgery Intern March, 1981 to Febuary, 1983 Hospital de Ipanema

Rio de Janeiro, RJ. Brasil

Urology Intern March, 1983 to Febuary, 1985

Universidade de Oxford Oxford, Reino Unido

Master in Surgery: Kidney Transplant

January, 1991 to October, 1993

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City, state & country:

Start date (dd-mmm-yyyy): Jul-1995 to Nov-2009 Position:

Médico Cirurgião do Setor de Cirurgia Geral Institution/organization:

Hospital Geral de Fortaleza Institution Address:

Rua Ávila Goular, 900 - Prédio Eletivo, 3o andar, Setor de Cirurgia Geral City, state & country:

Start date (dd-mmm-yyyy): Mar-1985 to Dec-1997

8. Clinical research experience (append publication list if available)

Área Phase Patients Time

Imunossupression in Kidney Transplantation Pré-clínica

NA 1991-1993

Imunossupression in Kidney Transplantation IV 13 1998-2000

Imunossupression in Kidney Transplantation III 15 2000-2002

9. Other activities pertinent to professional qualification

Title of Specialist in General Surgery, Colégio Brasileiro de Cirurgiões - 1982 Member of Brazilian College of Surgeons - 1983

Member of Brazilian Association of Organ Transplants - 1995 Member of American Society of Transplants - 2008

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10. Publications

Full Papers Published in Journals

1. Al-Shaibani K, Esmeraldo RM, Gray DWR, and Morris PJ. “Evaluation of SDZ.IMM 125, a new derivative of cyclosporine, in a kidney transplantation model in the dog.” Poster presentation, XIV International Congress of the Transplantation Society, Paris, France, August 1992.

2. Rahul M Jindal, Richard P Taylor, Derek WR Gray, Ronaldo Esmeraldo and Peter J Morris: “A new method for quantification of islets by measurement of zinc content.” Diabetes, Vol 41: 1056-1062, September 1992.

3. Hamelmann W, Esmeraldo RM, Gray DWR, and Morris PJ: “A method for isolation of islets from the rabbit pancreas.” Poster presentation, IV International Congress on Pancreas and Islet Transplantation, Amsterdam, The Netherlands, June 1993.

4. Ronaldo Esmeraldo, Khalid Al-Shaibani , Derek WR Gray, Michael S Dunnill, June Mason and Peter J Morris. “A new cyclosporin derivative, SDZ.IMM 125, prolongs renal allograft survival in dogs.” Transplant Immunogy, Vol 3: 167-173, 1995.

5.Esmeraldo RM, Donadi MORC, Oliveira ML, Ponte CN and Pinheiro PMA. “Micophenolate Mofetil with lower cyclosporine dose in high-risk renal transplant recipients.” Transplantation Proceedings 1999; 31 (7): 3007-8. 6. RM Esmeraldo, CS Pontes, RM Esmeraldo, JF Bruno, and LEB Arcoverde. “Revascularização cirúrgica na

estenose de artéria renal”. Arteríola, Vol 3, No. 2, 2001.

7. Romero de Matos Esmeraldo, Ronaldo de Matos Esmeraldo, Francisco Gilberto Pinheiro Rodrigues, José Ferreira Bruno Jr., Luiz Eduardo Bezerra Arcoverde, André de Sousa Castelo. “Transplante renal com artérias múltiplas: Análise retrospectiva de 108 casos e resultados a longo prazo”. Jornal Brasileiro de Transplantes 2003; Vol 6: 103-107

8. Vitko S, Tedesco H, Eris J, Pascual J, Whelchel J, Magee JC, Campbell S, Civati G, Bourbigot B, Filho GA, Leone J, Garcia VD, Rigotti P, Esmeraldo R, Cambi V, Haas T, Jappe A, Bernhardt P, Geissler J, Cretin N. “Everolimus with optimized cyclosporine dosing in renal transplant recipients: 6-month safety and efficacy results of two randomized studies”. Am J Transplant. 2004 Apr;4(4):626-35.

9. Helio Tedesco-Silva, Mark D Pescovitz, Diane Cibrik, Michael A Rees, Sramkant Mulgaonkar, Barry D Karran, Kristene K Gugliuzza, Ronaldo de M Esmeraldo, Hélène Lord, Maurizio Salvadori, and Jennifer M Slade for the FTY720 Study Groups. Randomized controlled trial of FTY720 verss MMF in de novo renal transplantation. Transplantation 2006; 82: 1689–9.

10. Tedesco-Silva Jr, Stefan Vitko, Julio Pascual, Josette Eris, John C. Magee, John Whelchel, Giovanni Civati, Scott Campbell, Gentil Alves-Filho, Bernard Bourbigot, Valter Duro Garcia, John Leone, Ronaldo Esmeraldo, Paolo Rigotti, Vincenzo Cambi, Tomas Haas, on behalf of the 2306 and 2307 study groups (2007). 12-month safety and efficacy of everolimus with reduced exposure cyclosporine in de novo renal transplant recipients. Transplant Int. 2007jan; 20 (1), 27–36.

11. C.M.C. Oliveira, M.L.M.B. Oliveira, S.C.A. Andrade, E.S. Girão, C.N. Ponte, M.U. Mota, P.F.C.B.C. Fernandes, H.H. Campos, R.M. Esmeraldo, J.B. Evangelista. Visceral Leishmaniasis in Renal Transplant Recipients: Clinical Aspects, Diagnostic Problems, and Response to Treatment. Transplantation Proceedings 2008 40 (3), Pages 755-760.

12. J. H. Garcia, G. R. Coelho, G. A. Marquesa, J. B. Gadelha, J. B. Vasconcelos, J. T. Valenca Jr, R. M. Esmeraldo, J. A. Meija, C. A. Leite and E. R. Almeida. Successful Organ Transplantation from Donors Poisoned with a Carbamate Insecticide. American Journal of Transplantation 2010; 10: 1–3

13. David-Neto E, Esmeraldo RM, Asano E, Nita ME, Nishikawa AM, Barbosa E, Szabo SM, Levy AR, Carvalho JF3, Donato BM, Rahal E, The KIT73 Study Group. KIT73 Study relationship between costs of care and 12-month glomerular filtration rates in post-transplant patients in the Brazilian public health system (SUS). Value in Health, 2011; 14 (3): A8.

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Theses and chapters of books published

1. Ronaldo Esmeraldo. “Aspects of immunosupression for prevention of renal allograft transplantatioin.” Tese de Mestrado, Universidade de Oxford, Reino Unido, agosto de 1994.

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Abstracts Published in Annals of Congress

1. RM Esmeraldo, RM Esmeraldo, MLV Costa, AS Castelo “Renal allograft transplantation with multiple arteries – A study of 52 cases.” Poster presentation, 6th

Congress of the Brazilian Society for Organ Transplantation, ABTO, Belo Horizonte, Brazil, April 1999.

2. RM Esmeraldo, MORC Donadi, ML Oliveira, CN Ponte e PMA Pinheiro. “Cyclosporine A acute nephrotoxicity – Cause of acute graft dysfunction in renal transplant recipients.” Poster presentation, 6th

Congress of the Brazilian Society for Organ Transplantation, ABTO, Belo Horizonte, Brazil, April 1999.

3. RM Esmeraldo, MORC Donadi, ML Oliveira, CN Ponte and PMA Pinheiro. “Micophenolate Mofetil with lower cyclosporine dose in high-risk renal transplant recipients.” Poster presentation, 9th

Congress of the European Society for Organ Transplantation, ESOT, Oslo, Norway, June 1999.

4. R.M. Esmeraldo, P.M.A. Pinheiro e R. P. Evangelista. “Induction therapy with basiliximab in high-risk kidney allograft recipients.” Pôster presentation, NEFRO 2000, XX Congress of the Brazilian Society of Nephrology, Natal, Brazil, September, 2000.

5. RM Esmeraldo, CMC Oliveira, JF Bruno, PMA Pinheiro and RP Evangelista. “Chronic allograft nephropathy: Effect of the addition of Micophenolate Mofetil”. Poster presentation, 7th

Congress of the Brazilian Society for Organ Transplantation, ABTO, Vitoria, Brazil, March, 2001.

6. RM Esmeraldo, PMA Pinheiro, JF Bruno, LMB Oliveira and RP Evangelista. “Basiliximab induction therapy in high-risk renal transplant recipients”. Poster presentation, 2001 A Transplant Odyssey, Istanbul, Turkey, August 2001.

7. RM Esmeraldo, JF Bruno, LMB Oliveira, PMA Pinheiro and CN Ponte. “Neoral monitoring based on two-hour post-dose levels (C-2) in de novo kidney allograft recipients”. Poster presentation, 2001 A Transplant Odyssey, Istanbul, Turkey, August 2001.

8. RM Esmeraldo, PMA Pinheiro, JF Bruno, LMB Oliveira and RP Evangelista. “Basiliximab induction therapy in high-risk renal transplant recipients”. Poster presentation, 10th

Congress of the European Society for Organ Transplantation, ESOT, Lisbon, Portugal, October 2001.

9. A Castelo, LE Bezerra, JF Bruno, and RM Esmeraldo. “Living donor laparoscopic nephrectomy – Preliminary data of 21 patients”. Oral presentation, V Congresso Norte/Nordeste de Urologia, Maceió, Brazil, 25 to 28/March/2002. 10. IN Farias, SL Silva, MCS Cavalcante, RM Esmeraldo, HH campos, and SFR Silva. “Reatividade contra painel de

linfócitos de 91 pacientes renais transplantados após a criação da Central de Transplantes do Estado do Ceará”. Poster presentation, XXIX Congresso Brasileiro de Análises Clínicas, Fortaleza, Brazil, 26 to 30/May/2002. 11. RM Esmeraldo, CN Ponte, MLB Oliveira, S Daher, MNA Pinheiro and RP Evangelista. “Total steroid avoidance in

pediatric renal transplantation with daclizumab induction therapy and mycophenolate mofetil and tacrolimus maintenance therapy”. Program and abstracts of American Transplant Congress 2003: The Fourth Joint American Transplant Meeting; May 30-June 4, 2003; Washington, DC. Abstract 1181.

12. Esmeraldo, RM, Esmeraldo, R. and Rodrigues, FGP Multiple renal arteries from living donors: more than three arteries does not contraindicate donation. Poster presentation, 8th Congress of the Brazilian Society for Organ Transplantation, ABTO, Fortaleza, Brazil, June, 2003.

13. CC, Oliveira, MOR, Cavalcante, RM Esmeraldo, MLMB, OLIVEIRA, JL, Araujo, CN, Ponte, FN, Paes, RP Evangelista. “Tacrolimus em transplante renal”. Poster presentation, 8th Congress of the Brazilian Society for Organ Transplantation, ABTO, Fortaleza, Brazil, June, 2003.

14. RM Esmeraldo, MLB Oliveira, MNA Pinheiro, CN Ponte, S Daher, Maria Ocilma R Cavalvante, Claudia M Oliveira e RP Evangelista. “ Transplante renal em crianças sem corticosteróides – resultados preliminares da indução com daclizumab seguida de manutenção com mmf e tacrolimus. Abstract presentation, 8th Congress of the Brazilian Society for Organ Transplantation, ABTO, Fortaleza, Brazil, June, 2003.

15. RM Esmeraldo, AS Castelo, LE Arcoverde, JF Bruno, RM Esmeraldo e FGP Rodrigues. “Nefrectomia do doador vivo: Comparação entre as técnicas de cirurgia convencional e aberta”. Poster presentation, 8th

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Abstracts Published in Annals of Congress

20. Romero M. Esmeraldo, Ronaldo M. Esmeraldo and Francisco G.P. Rodrigues. “Multiple renal arteries from living donors: more than two arteries does not contraindicate donation”. Poster presentation, 11th

Congress of the European Society for Organ Transplantation, ESOT, September, 2003, Venice, Italy. Poster 386.

21. Ronaldo M. Esmeraldo, Jose F. Bruno, Luiz E. Arcoverde, André S. Castelo, and Romero M. Esmeraldo. “Laparoscopic living donor nephrectomy without the use of stapler devices: a series of ninety consecutive cases”. Poster presentation, 11th Congress of the European Society for Organ Transplantation, ESOT, Venice, Italy, September, 2003.

22. J Pascual, V Cambi, D Dissegna, R Esmeraldo, M Lao, M Durlik, L Paczek, and T Haas. Efficacy and safety of 2 doses of everolimus combined with reduced dose of neoral in de novo kidney transplant recipients: 24 months analysis. Program and abstracts of the Annual Meeting of the American Transplant Congress; May 21-25, 2005; Seattle, Washington. Abstract.

23. Oliveira, C.M.C, Oliveira, M.L.M.B, Silva, S.L, Marcelo e Esmeraldo, R.M “Infecção por citomegalovírus (CMV) e hemofagocitose pós-transplante renal - Relato de caso”. Poster presentation, 9th

Congress of the Brazilian Society for Organ Transplantation, ABTO, Salvador, Brazil, July 2-6, 2005.

24. Esmeraldo RM, Silva SL, Pinheiro MNA, Oliveira MLMB, and Evangelista RP. “Imunossupressão sem esteroides em adultos transplantados renais – Experiencia de um único centro”. Oral presentation, 9th

25. RM Esmeraldo, AS Castelo, JF Bruno, LE Arcoverde, RM Esmeraldo. “Nefrectomia do doador vivo: Comparação entre as técnicas de cirurgia convencional e aberta”. Poster presentation, 9th

26. RM Esmeraldo, RM Esmeraldo, AS Castelo, JF Bruno, and LE Arcoverde,. “Técnicas de alongamento da veia renal direita no transplante renal com rim de doador cadáver”. Poster presentation, 9th

27. Sampaio FPR, Barbosa IV; VIANA MCA; and Esmeraldo, RM. “Prevalência de doador cadáver com critérios expandido para transplante renal”. Poster presentation, 9th

28. Silva SL, Oliveira MLB, Oliviera CMC, and Esmeraldo RM. “Ulcerações orais relacionadas ao uso de rapamicina – Relato de caso”. Poster presentation, 9th

29. Esmeraldo RM, Silva SL, Leite NF, Silva SFR. “Interação farmacocinética entre tacrolimo e esteroides em receptores de transplante renal”. Poster presentation, 9th

30. Ronaldo M. Esmeraldo, Maria L.M.B. Oliveira, Maria N.A. Pinheiro, Carlos N. Ponte, and Regia P. Evangelista. “Imunossupressão sem esteroides em transplante pediatrico – Avaliação de longo prazo”. Oral presentation, 10th Congress of the Brazilian Society for Organ Transplantation, ABTO, Florianopolis, Brazil, September 2-7, 2007. 31. R. Esmeraldo, P. Pinheiro, M. Oliveira, C. Ponte, M. Donadi, S. Costa, F. Paes, C. Soares, R. Evangelista.

“Steroid-free immunosuppression in pediatric renal transplantation – Long-term follow-up analyis”. Poster presentation, Abstract #1887, XXII Congress of the International Society of the Transplantation Society, Sydney, Australia, August 10-14, 2008.

32. Petrúcia Maria Antero Pinheiro. Steroid-Free Immunosuppression in Pediatric Renal Transplantation – A 12 Year Follow-Up. Apresentação de trabalho no Congresso Mundial de Transplantes 2014, São Francisco, Estados Unidos da América, julho de 2014.

33. Ronaldo Esmeraldo, Petrucia Maria Antero Pinheiro. “One-year results of a prospective randomized open trial designed to reduce the incidence of cytomegalovirus (CMV) infection in de novo kidney transplant recipients”. Apresentação oral no Congress of the European Society for Organ Transplantation, ESOT 2015, Bruxelas, Bélgica, setembro de 2015.

34. Ronaldo M. Esmeraldo, Petrúcia A. Pinheiro, Rebeca C. Costa, Maria Luíza B. Oliveira, Juliana R. Oliveira. Imunossupressão sem esteroides em transplante pediátrico. Apresentação oral no XIV Congresso Brasileiro de Transplantes, Gramado-RS, Brasil, outubro de 2015.

35. Ronaldo Esmeraldo, Maria L.M.B. Oliveira, Petrucia M.A. Pinheiro, Celi M. Girão. Prospective randomized open trial designed to reduce the incidence of cytomegalovirus infection in de novo kidney transplant recipients: Two-year results. Apresentação oral no American Transplant Congress 2016, Boston, Estados Unidos da América, junho de 2016.