blood-brain barrier
Blood-Brain Barrier Effects of the Fusarium Mycotoxins Deoxynivalenol, 3 Acetyldeoxynivalenol, and Moniliformin and Their Transfer to the Brain.
... The blood-brain barrier (BBB) is a highly selective permeability barrier separating the blood stream from the interstitial fluid in the ...This barrier controls the nutrient ...
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Pharmacokinetic analysis of 111 in-labeled liposomal Doxorubicin in murine glioblastoma after blood-brain barrier disruption by focused ultrasound.
... Malignant brain tumors remain difficult to treat using chemotherapy because the blood-tumor barrier (BTB) limits the amount of potent agents that can be delivered to the tumor; the result is that the ...
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Blood brain barrier and neuroinflammation are critical targets of IGF-1-mediated neuroprotection in stroke for middle-aged female rats.
... of blood brain barrier permeability at 4h post- stroke and global suppression of cytokines including IL-6, IL-10 and ...the blood brain barrier may serve as critical targets of ...
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Opiates Upregulate Adhesion Molecule Expression in Brain MicroVascular Endothelial Cells (BMVEC): Implications for Altered Blood Brain Barrier (BBB) Permeability
... The blood-brain barrier (BBB) is an intricate cellular system composed of vascular endothelial cells and perivascular astrocytes that restrict the passage of immunocompetent cells into the central ...
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Spatiotemporal correlations between blood-brain barrier permeability and apparent diffusion coefficient in a rat model of ischemic stroke.
... Blood-brain barrier (BBB) disruption is an important patholog- ical hallmark of ischemia with or without reperfusion, and it is associated with vasogenic edema, hemorrhagic transformation, and has ...
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A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells.
... human blood brain barrier (BBB) is a selective barrier formed by human brain endothelial cells (hBECs), which is important to ensure adequate neuronal function and protect the central ...
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Targeted brain derived neurotropic factors (BDNF) delivery across the blood-brain barrier for neuro-protection using magnetic nano carriers: an in-vitro study.
... agent; brain derived neurotropic factor (BDNF), which protects neurons against these effects, could be of therapeutic benefit in the treatment of opiate ...the blood brain barrier (BBB) ...
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Sex-specific signaling in the blood-brain barrier is required for male courtship in Drosophila.
... The blood–brain barrier integrity is not compromised in SPG-Gal4/UAS-TraF ...the brain was observed by confocal microscopy. The brain nuclei are stained with ...the brain ...
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Vascular endothelial growth factors enhance the permeability of the mouse blood-brain barrier.
... The blood-brain barrier (BBB) impedes entry of many drugs into the brain, limiting clinical ...significant brain edema was observed by diffusion weighted MRI (DWI) or histological ...
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Inflammation Modulates RLIP76/RALBP1 Electrophile-Glutathione Conjugate Transporter and Housekeeping Genes in Human Blood-Brain Barrier Endothelial Cells.
... Treatment of human endothelial cells in a BBB model with TNF-α led to the induction of sev- eral inflammation markers indicating an inflammatory response. Under these conditions, the expression of housekeeping genes such ...
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Treatment with the NK1 antagonist emend reduces blood brain barrier dysfunction and edema formation in an experimental model of brain tumors.
... the blood-brain barrier (BBB) and development of cerebral edema in acute brain ...around brain tumors and has been linked to several tumor-associated ...of brain peritumoral ...
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Preservation of the blood brain barrier and cortical neuronal tissue by liraglutide, a long acting glucagon-like-1 analogue, after experimental traumatic brain injury.
... the brain parenchyma plays a key role in edema formation ...acute brain injury, for instance Exendin-4 reduced IBA-1 positive microglia activation in experimental model of global ischemia and in stroked ...
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Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Galliformes; Aves)
... the brain 5-HT, a little less than 2% of the indoleamine is produced in the central nervous system relative to the whole organism (Cooper et ...the blood brain barrier (BBB) towards the ...
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Fingolimod prevents blood-brain barrier disruption induced by the sera from patients with multiple sclerosis.
... the blood, thereby reducing autoaggressive lymphocyte infil- tration into the central nervous system (CNS) ...on brain microvascular endothelial cells (BMECs) comprising the blood-brain ...
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Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction.
... in brain endothelium, was ...in brain endothelial cells of microvessels ...in brain tissues. As shown in Fig 4B, the brain microvessels (arbitrarily determined by the size <5 μM; denoted by ...
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Nanoparticle mediated P-glycoprotein silencing for improved drug delivery across the blood-brain barrier: a siRNA-chitosan approach.
... The blood-brain barrier (BBB), composed of tightly organized endothelial cells, limits the availability of drugs to therapeutic targets in the central nervous ...The barrier is maintained by ...
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Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection, and Neurobehavioral Recovery After Experimental Ischemic Stroke
... Docosahexaenoic acid (DHA) and neuroprotectin D1 (NPD1) are neuroprotective after experimental ischemic stroke. To explore underlying mechanisms, SD rats underwent 2 h of middle cerebral artery occlusion (MCAo) and ...
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West Nile virus-induced cell adhesion molecules on human brain microvascular endothelial cells regulate leukocyte adhesion and modulate permeability of the in vitro blood-brain barrier model.
... causes blood-brain barrier (BBB) disruption, leukocyte infiltration into the brain and neuroinflammation is important to understand the pathogenesis of WNV ...human brain microvascular ...
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Vitamin D prevents hypoxia/reoxygenation-induced blood-brain barrier disruption via vitamin D receptor-mediated NF-kB signaling pathways.
... blood-brain barrier (BBB) disruption. Following hypoxic injury, an increase in intracellular reactive oxygen species (ROS) causes mitochondrial dysfunction, which further leads to intracellular ...
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Neuroinvasion of the highly pathogenic influenza virus H7N1 is caused by disruption of the blood brain barrier in an avian model.
... cryostat brain sections from two infected chickens perfused with EB and three perfused with PBS, as well as sections from control chickens, were processed as described above for the detection of the influenza A ...
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