BRAF V600E
Análise imunohistoquímica da mutação BRAF V600E em ameloblastomas mandibulares
... No quesito tamanho, apenas um estudo tentou correlacionar essa variável com a presença do BRAF V600E. Fregnani et al. (2017) não encontraram diferença com significância estatística comparando ameloblastomas ...
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Proper indication of BRAF(V600E) mutation testing in fine-needle aspirates of thyroid nodules.
... detecting BRAF V600E mutation plays an additional role in the definitive diagnosis of thyroid nodules [8–10], performing routine BRAF V600E mutation analysis in addition to fine-needle ...
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BRAF V600E Mutation and 9p21: CDKN2A/B and MTAP Co-Deletions - Markers in the Clinical Stratification of Pediatric Gliomas
... a BRAF V600E mu- tation ab initio and the observed latency period until the development of the HGG was two ...a BRAF V600E mutation and had a much longer latency period until the development ...
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Association between BRAF (V600E) mutation and clinicopathological features of papillary thyroid carcinoma: a Brazilian single-centre case series
... FFPE blocks were obtained from the archives of the Department of Anatomic Pathology and Cytopathology at Sao Rafael Hospital in order to acquire thyroid tumour samples for BRAF (V600E) mutation analysis. ...
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Differential inhibition of ex-vivo tumor kinase activity by vemurafenib in BRAF(V600E) and BRAF wild-type metastatic malignant melanoma.
... (a) BRAF splicing variants (p61BRAF(V600E)) lacking the RAS- binding domain [36]; (b) phosphatase and tensin homolog (PTEN) loss leading to elevated PI3K/AKT signaling [37]; (c) increased PDGFRb expression ...
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Tumorigenesis of papillary thyroid cancer is not BRAF-dependent in patients with acromegaly.
... In conclusion, the rate of thyroid cancer was extremely high (25%) in our study, and it was the most common cancer among our patients with acromegaly. Uncontrolled acromegaly implies that persistently elevated GH and ...
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The prognostic value of BRAF mutation in colorectal cancer and melanoma: a systematic review and meta-analysis.
... We started summarizing the effect of BRAF-V600E mutation on patient survival separately based on study design RCT versus cohort and cancer type. We evaluated the publication bias using funnel plot analysis. ...
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AGK-BRAF gene fusion is a recurrent event in sporadic pediatric thyroid carcinoma
... the BRAF V600E mutation, the most common genetic event found in adult PTC [13], is significantly lower in sporadic and radiation- exposed pediatric PTC [14, 15, ...
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Efeito do oncogene BRAF e da GTPase Rac1b sobre a expressão dos genes envolvidos no estado de senescência de células do cólon humano
... de BRaf-V600E em células NCM460 aumenta a expressão dos marcadores de senescência p14 e p15 enquanto os mesmos marcadores diminuem quando se induz a expressão da GTPase Rac1b, o que reforça o conceito de ...
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BRAF Mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma
... the BRAF-KIAA1549 fusion. The most recurrent alterations were BRAF V600E and CDKN2A deletion in 39% and 57% of sHGGs, ...all BRAF V600E and 80% of CDKN2A alterations could be traced ...
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Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling.
... with BRAF V600E ...oncogenic BRAF-driven hyperactivation of the RAS-RAF-MEK-ERK signaling ...with BRAF V600E (Table ...harboring BRAF V600E ...
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Characterization of the Population with BRAF V600 Mutation in Patients with Metastatic Cutaneous Melanoma in a Tertiary Center
... 4800 BRAF V600 Mutation Test), no Serviço de Ana- tomia Patológica do IPOLFG, preferencialmente utilizan- do tecido ...mutação BRAF no ADN isolado de tecido tumoral fixado em formol e conservado em ...
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Possible therapies to overcome resistance to MAPK inhibitors in mutant BRAF melanoma
... In this project, two melanoma cell lines were tested, ED013 and ED013R2. ED013 is a vemurafenib-sensitive melanoma cell line, with BRAF V600E mutation. ED013R2 was generated from ED013 and is a ...
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Mutação do gene BRAF na história natural do carcinoma papilar da tireóde: implicações diagnósticas e prognósticas
... Mutated BRAF, generates a constitutive activation of the mitogen-activated protein kinases (MAPK) signaling pathway, which plays a critical role in transmitting proliferative signals generated by cell surface ...
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mTOR pathway in BRAF mutated papillary thyroid carcinoma.
... increased BRAF signaling leads to mTOR pathway activation and suggest that inhibition of both MAPK and mTOR pathways could be a good strategy in therapeutic targeting of BRAF V600E - positive ...of ...
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UNIVERSIDADE FEDERAL DO PARÁ INSTITUTO DE CIÊNCIAS BIOLÓGICIAS PROGRAMA DE PÓS-GRADUAÇÃO EM BIOLOGIA CELULAR E NEUROCIÊNCAS INVESTIGAÇÃO DE OCORRÊNCIA DE ALTERAÇÕES MOLECULARES NOS GENES KRAS, HRAS, NRAS E BRAF EM CARCINOMA PAPILÍFERO DA TIREOIDE
... and BRAF in patients with PTC treated in a public hospitals, from Belém (PA), seeking to make an association between the mutations found and the biochemical and clinical ...only BRAF showed a mutation, ...
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Prevalence of BRAF Mutation in Papillary Thyroid Cancer
... the BRAF protein, which is involved in a pathway that controls and regulates many cellular processes, like; cellular proliferation, differentiation and ...which BRAF mutations are the most commonly observed ...
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Seven-year follow-up of a juvenile female with papillary thyroid carcinoma with poor outcome, BRAF mutation and loss of expression of iodine-metabolizing genes
... that BRAF V600E mutation, the most prevalent genetic event found in papillary thyroid carcinoma, is an indepen- dent poor prognostic ...with BRAF V600E mutation in primary tumor and a new ...
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Mutação BRAF em pacientes idosos submetidos à tireoidectomia.
... mutação BRAF V600E apenas em casos de carcinomas ...mutação BRAF, além de demonstrar associação com significância estatística entre a variante clássica do carcinoma papilífero e a presença da mutação ...
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Alterações moleculares na tumorigênese tireoidiana: análise imunohistoquímica da expressão das proteínas WWOX, FHIT, p53 e BRAF no Carcinoma Papilífero de Tireóide
... Os avanços no conhecimento em relação à tumorigênese do CPT já estão bem esclarecidos e estabelecidos no que se refere ao papel dos oncongenes (BRAF, RET/PTC, RAS) em sua patogênese. Na última década, diversos ...
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