Broad spectrum
EXPRESSION OF MOUSE BETA DEFENSIN 2 IN ESCHERICHIA COLI AND ITS BROAD-SPECTRUM ANTIMICROBIAL ACTIVITY Tianxiang Gong
... Mature mouse beta defensin 2 (mBD2) is a small cationic peptide with antimicrobial activity. Here we established a prokaryotic expression vector containing the cDNA of mature mBD2 fused with thioredoxin (TrxA), ...
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Surveillance of broad-spectrum antibiotic prescription in Singaporean hospitals: a 5-year longitudinal study.
... Broad-spectrum antibiotic prescription results according to antibiotic class are depicted in Figure 1, with significant trends in prescription over time by class and individual antibiotic highlighted in ...
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Isolation and characterization of broad spectrum coaggregating bacteria from different water systems for potential use in bioaugmentation.
... It was known that immobilization of degrading-bacteria was a key for successful wastewater treatment in the bioaugmentation system. Biofilms, as natural forms of cell immobilization in wastewater treatment systems, have ...
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A Multicenter Comparative Study of Cefepime Versus Broad-Spectrum Antibacterial Therapy in Moderate and Severe Bacterial Infections
... In a second surveillance study conducted in Latin America, less than half of E. coli isolates obtained from hospitalized patients with UTIs were susceptible to broad-spectrum penicillins; in vitro ...
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Competition between Phytophthora infestans effectors leads to increased aggressiveness on plants containing broad-spectrum late blight resistance.
... Late blight remains a worldwide problem for potato production. P. infestans is a particularly destructive pathogen and can lead to significant crop losses due to early defoliation and tuber infection. The pathogen ...
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An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development.
... In turn, the ideal anticancer therapeutic would have a broad spectrum, suggesting it would be more advantageous to target a phenotype common in cancer. CIN in the form of aneuploidy is seen in .90% of solid ...
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Establishment of a broad-spectrum marker for er1/PsMLO1 powdery mildew resistance in pea (Pisum sativum L.)
... Powdery mildew caused by the biotrophic ascomycete fungus Erysiphe pisi Syd. is one the most devastating diseases of (Pisum sativum L.) with a considerable impact in seed production. So far, the most efficient genetic ...
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Broad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides
... conjugation enhanced the potency of inhibitory peptides and allowed them to penetrate the CNS, while the effect of addition of a PEG3 linker between the N-terminal cholesterol and the inhibitory peptide was less clear. ...
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Legionella shows a diverse secondary metabolism dependent on a broad spectrum Sfp-type phosphopantetheinyl transferase
... Using the program abricate, we additionally analysed the genomes for possible antibiotic resistance genes. In L. anisa, L. cherrii, L. longbeachae, L. sainthelensis and L. wadsworthii beta-lactamase resistance was ...
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Accuracy of three automated systems (MicroScan WalkAway, VITEK, and VITEK 2) for susceptibility testing of Pseudomonas aeruginosa against five broad-spectrum beta-lactam agents
... Recent reports from an increasing number of hospitals of antibiogram inconsistencies between broad-spectrum ceph- alosporins and piperacillin-tazobactam when P. aeruginosa is tested drew our attention to ...
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A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion
... LJ001 is a membrane-binding compound with broad-spectrum antiviral activity in vitro. LJ001 acts on the virus, and not the cell, inhibiting enveloped virus infection at the level of entry [4]. LJ001 is ...
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Broad spectrum pro-quorum-sensing molecules as inhibitors of virulence in vibrios.
... Quorum sensing (QS) is a bacterial cell-cell communication process that relies on the production and detection of extracellular signal molecules called autoinducers. QS allows bacteria to perform collective activities. ...
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Potent and broad-spectrum antimicrobial activity of analogs from the scorpion peptide stigmurin
... demonstrated broad-spectrum antimicrobial activity in vitro, showing an effect superior to that of the native peptide, being non-hemolytic at the biologically active ...
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Exoproteome and secretome derived broad spectrum novel drug and vaccine candidates in Vibrio cholerae targeted by Piper betel derived compounds.
... Table S2 Features of the identified 10 targets in V. Cholerae. Ten V. cholerae O395 targets were selected based on subtraction proteomics. VC0395_0360 and VC0395_0374 are located in Chromosome-I (Ch-I), whereas the other ...
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Vaccination with embryonic stem cells protects against lung cancer: is a broad-spectrum prophylactic vaccine against cancer possible?
... To investigate whether ESC/ STO-GM vaccination elicits CD8 responses, splenocytes from ESC/STO-GM vaccinated and non-vaccinated (control) mice were assessed for in vitro tumor cell killi[r] ...
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THE BROAD SPECTRUM OF BIOACTIVE PROPERTIES OF PHENOLIC EXTRACTS: A PROSPECTIVE STUDY IN THREE DIFFERENT PLANTS Inès Jabeur
... Medicinal plants have been utilised for several years because of their therapeutic and health promoting benefits. The present study revealed that medicinal plants contain a lot of bioa[r] ...
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A broad-spectrum beta-lactam-sparing stewardship program in a middle-income country public hospital: antibiotic use and expenditure outcomes and antimicrobial susceptibility profiles
... In summary, a semi-restrictive ASP based on sparing extended-spectrum beta-lactams was an effective strategy for reducing targeted antibiotic consumption in a hospital set- ting and maintaining susceptibility ...
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Resistance to Broad-Spectrum Antibiotics in Aquatic Systems: Anthropogenic Activities Modulate the Dissemination of blaCTX-M-Like Genes
... resistance patterns against the following 16 antibiotics from 6 classes were determined by the agar disc diffusion method on Mueller-Hinton agar: beta-lactams (penicillins; monobactams; carbapenems; and narrow-spec- ...
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Cronotopia: um fenômeno de largo espectro / Chronotopy: A Broad-Spectrum Phenomenon
... Na verdade, Benveniste assinala: só há uma expressão temporal – o presente (coincidência acontecimento/discurso). Desse modo, ao lado dele, há os tempos “não-presentes”, de nível difer[r] ...
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Antimicrobial activities of tigecycline and other broad-spectrum antimicrobials tested against serine carbapenemase- and metallo-beta-lactamase-producing enterobactefiaceae: Report from the SENTRY antimicrobial surveillance program
... Among 50,881 Enterobacteriaceae collected in the 6-year pe- riod (2000 to 2005), a total of 261 isolates (0.5%) showed reduced susceptibility to imipenem or meropenem (MIC, ⱖ 2 g/ml) a[r] ...
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