CagA protein
Helicobacter pylori counteracts the apoptotic action of its VacA toxin by injecting the CagA protein into gastric epithelial cells.
... direct activity of VacA on mitochondria for toxin-induced cell death is supported by the observation that mutations of the N- terminal p37 domain of VacA which blocks the transfer of the toxin into mitochondria also ...
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Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner.
... translocated CagA and IL-8 induction (Table ...proteins CagA, CagY, CagL and probably ...A, CagA; Y, CagY; L, CagL protein; E, EGF-like1-4; b, b-tail domain; H, Hybrid; I, I-like; P, PSI ...
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SERVIÇO PÚBLICO FEDERAL UNIVERSIDADE FEDERAL DO PARÁ NÚCLEO DE MEDICINA TROPICAL PROGRAMA DE PÓS-GRADUAÇÃO EM DOENÇAS TROPICAIS
... pylori CagA cytotoxin, encoded by the cagA gene, has been associated with increased inflammatory response in gastric tissue and the change in control of cell growth and ...of CagA protein of ...
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Estudo histopatológico e imuno-histoquímico da mucosa gástrica de gerbils (Meriones unguiculatus) infectados por linhagens de Helicobacter pylori com diferentes ilhas de patogenicidade
... the CagA protein and a functional ...different CagA phos- phorylation sites in a classic experimental model for studying this type of ...that CagA from both isolates were translocated and ...
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Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of Western-type Helicobacter pylori strains.
... of CagA phosphorylation events ...translocated CagA molecules undergoing phosphorylation at a specific site, from increased phosphorylation of multiple sites per CagA molecule, or both – ...
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Soroprevalência de anticorpos contra o antígeno CagA do Helicobacter pylori em pacientes com úlcera gástrica na região Norte do Brasil.
... one of the main etiological factors in the development of gastric ulcer. Based on this information, we investigated the seroprevalence of virulent strains among patients with gastric ulcer from one region, using ...
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cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis
... in cagA-negative ...with cagA positive strains is linked to enhanced interleukin-8 (IL-8) secretion by the gastric mucosa ...However, cagA-negative mutants that do not contain CagA ...
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Sítios de fosforilação de tirosina da proteína caga e genótipos cage do H. pylori em pacientes com gastrite e úlcera péptica
... of CagA protei - EPIYA, has not been fully elucidated existing geographical ...of CagA protein EPIYA and presence of genes cagE in patients with gastritis and peptic ulcer disease, and to correlate ...
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The effect of CagA status on response to
... the CagA protein induce gastric epithelial cells to se- crete inflammatory cytokines ...with CagA positivity and showed enhanced inflammation by more virulent ...against CagA protein ...
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Avaliação do padrão e número de sítos de fosforilação (EPIYA) da proteína CagA de H. pylori e risco de carcinoma gástrico e úlcera duodenal
... factors, CagA protein has been associated with both ...of CagA occurs within tyrosine phosphorylation motifs containing EPIYA ...pylori CagA protein with higher number of EPIYA C ...
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Association among H. pylori virulence markers dupA, cagA and vacA in Brazilian patients
... vacA genotypes were also investigated in the present study, and an important association was found between s1/m1 genotype and the presence of dupA gene, whereas H. pylori dupA-negative strains were associated with ...
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Targeting protein-protein interactions for parasite control.
... the protein is ...sapiens protein has mainly alpha-helical character. Like many PPIs, this protein might undergo a disorder-to-order transition upon binding its protein partner[27], making the ...
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Genótipos cagA , vacA e alelos e sítios de fosfolilação de tirosina da proteína caga do h. pylori em pacientes com e sem história familiar de câncer gástrico
... incluindo cagA, cagE, cagH, cagI e cagL, dentre outros (CENSINI et ...gene cagA é comumente usado para identificar o locus cag (GONZALLES et al, 2003), e a maioria dos genes cag estão provavelmente ...
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Genótipos cagA, vacA e alelos de H. pylori em pacientes portadores de gastrite, úlcera péptica e câncer gástrico
... genes cagA e vacA e alelos através da técnica de ...gene cagA foi observado em 82,8% das cepas, onde 73,7% tinham gastrite e cagA positivo, 96,4% tinham úlcera péptica e 96,7% portavam câncer ...
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Luisa Caricio Martins+ , Tereza Cristina de Oliveira Corvelo, Samia Demachki, Marialva TF Araujo, Mônica Baraúna Assumpção, Simone Cristina Araujo Jucá Vilar, Felipe Bonfim Freitas, Hivana Patricia Melo Barbosa, Amanda Alves Fecury, Renata Kelly Costa do
... gene cagA and vacA alleles in 129 patients, 69 with gastritis and 60 with peptic ulcer diseases from North Brazil and their relation with histopathological ...and cagA genotype were determined by polymerase ...
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Luisa Caricio Martins+ , Tereza Cristina de Oliveira Corvelo, Samia Demachki, Marialva TF Araujo, Mônica Baraúna Assumpção, Simone Cristina Araujo Jucá Vilar, Felipe Bonfim Freitas, Hivana Patricia Melo Barbosa, Amanda Alves Fecury, Renata Kelly Costa do
... gene cagA and vacA alleles in 129 patients, 69 with gastritis and 60 with peptic ulcer diseases from North Brazil and their relation with histopathological ...and cagA genotype were determined by polymerase ...
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Rev. Soc. Bras. Med. Trop. vol.46 número3
... diversity in dietary habits in the Amazon region as a whole due to differences in environmental conditions. Whereas the diet of the rural population consists of fruits, game, and fi sh, complemented by cassava fl our, the ...
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What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseases
... The cagA gene is a recognized marker for the presence of ...immuno-dominant protein (CagA) that once injected into the gastric epithelial cell cytoplasm interacts with host cell proteins, inducing ...
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Infecção por Helicobacter pylori e câncer gástrico: freqüência de cepas patogênicas cagA e vacA em pacientes com câncer gástrico.
... patogênicas cagA e vacA do ...genótipos cagA e vacA em amostras de material fixado em formalina e incluído em ...gene cagA foi detectado em amostras de 23 pacientes (54,7%) com câncer ...patogênicos ...
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Características da gastrite crônica associada a Helicobacter pylori: aspectos topográficos, doenças associadas e correlação com o status cagA.
... pacientes cagA-positivos o antro e a porção distal do corpo apresen- tavam o mesmo grau de inflamação e atrofia, enquanto nos cagA-negativos o antro estava significativamente mais comprometido do que o ...
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