Complement system
Microbe-specific C3b deposition in the horseshoe crab complement system in a C2/factor B-dependent or -independent manner.
... mammalian complement system is an important immune surveillance system involving more than 30 factors in plasma or on cytoplasmic membrane; complement C3 is activated via three convergent ...
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The role of salivary and intestinal complement system inhibitors in the midgut protection of triatomines and mosquitoes.
... the complement system operation at pHs different from ...the complement is really dangerous to the insects in order to ‘‘force’’ them to produce inhibitors, complement should be active in the ...
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Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways
... Fig. 1 Effect of Bjussu and Bpir crude venom on the hemolytic activity of the complement system. This figure depicts the concentration-dependent inhibitory effect of (a, c, and e) Bjussu and (b, d, and f) ...
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Inefficient complement system clearance of Trypanosoma cruzi metacyclic trypomastigotes enables resistant strains to invade eukaryotic cells.
... to complement killing in normal human serum at nearly physiological conditions (50% of serum at 37 uC) after incubations ranging from 5 to 30 minutes (not ...human complement at nearly physiological serum ...
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In vitro AND in situ ACTIVATION OF THE COMPLEMENT SYSTEM BY THE FUNGUS Lacazia loboi
... Since there are no studies evaluating the participation of the complement system (CS) in Jorge Lobo’s disease and its activity on the fungus Lacazia loboi, we carried out the present investigation. Fungal ...
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Biological characterization of compounds from Rhinella schneideri poison that act on the complement system
... and diluted serum (1:20; 37.5 μL) for one hour at 37 °C. After the incubation period, erythrocyte-antibody sus- pension (100 μL) was added to the samples and a new incubation was performed for 30 min at 37 °C. At the end ...
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Melanin particles isolated from the fungus Fonsecaea pedrosoi activates the human complement system
... the complement system in human serum in vitro (mainly via the alternative ...that complement consumption was higher when pigmented mycelia were used (Pinto et ...
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A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples.
... three complement pathways and are tested in clinical studies for aHUS as well as AMD, respectively ...alternative complement system, while the proteases are only indirectly blocked ...for ...
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Transcriptome Analysis of the Innate Immunity-Related Complement System in Spleen Tissue of Ctenopharyngodon idella Infected with Aeromonas hydrophila.
... A total of 49,975 unigenes (26.06%) were matched to 25 eukaryotic orthologous groups (annotated using the eggNOG Functional Category database; [52]) and all of them were deter- mined (Fig 3B). The largest category was ...
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Hepatitis C virus NS3/4A protease inhibits complement activation by cleaving complement component 4.
... signaling system to inhibit the host immune response and prevent viral clearance, thereby contributing to persistent HCV ...and complement components has not been previously ...of complement C3 or C4 ...
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Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats.
... The complement system has been increasingly recognized to play a pivotal role in a variety of inflammatory and autoimmune ...the complement system are currently in pre- clinical and clinical ...
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An overview on the treatment for atypical hemolytic uremic syndrome
... Atypical hemolytic uremic syndrome (aHUS) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure caused by a dysregulation in the complement system, specifically in ...
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The role of complement in the early phase of Leishmania (Leishmania) amazonensis infection in BALBc mice
... the complement system in cutaneous ...serum complement activity was meas- ured by hemolytic assay and C3 fragment deposit at the inoculation site was determined by direct immunofluorescence in the ...
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C3b/iC3b deposition on Streptococcus pneumoniae is not affected by HIV infection.
... the complement system [12,18]. Complement is activated through one of three major routes, known as the classical, alternative and mannose-binding lectin ...classical complement pathway ...
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The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b.
... [1,2]. Complement, which mediates a powerful immediate innate immune defense of vertebrate hosts, is activated, within seconds upon entry of a foreign invader ...the complement system occurs through ...
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Complement activation in atypical hemolytic uremic syn- drome and scleroderma renal crisis: a critical analysis of pathophysiology
... terminal complement complex ...the complement system is con- stitutively active and its activity is kept in check by several soluble and membrane-bound complement ...soluble complement ...
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J. Bras. Nefrol. vol.39 número4
... the complement system activation pathways is the fact that there may be other antigens (like thrombospon- din, bovine serum albumin, superoxide dismutase 2 and aldose reductase) than only PLA2R in MN, whose ...
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Human leishmaniasis in Brazil: A general review
... Transiently in the vertebrate host’s bloodstream, be- fore infecting the macrophages, the first immune system barrier encountered by the parasites after transmission is the complement system. ...
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Location of pathogenic bacteria during persistent infections: insights from an analysis using game theory.
... Interaction of a bacterial pathogen with a host is a clear case of conflict of interest. Bacteria aim to increase their payoff by multiplying as much as possible and then by getting transmitted out of the host as ...
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SNAKE ANTIVENOMS: ADVERSE REACTIONS AND PRODUCTION TECHNOLOGY Morais VM (1), Massaldi H (1)
... ABSTRACT: Antivenoms have been widely used for more than a century for treating snakebites and other accidents with poisonous animals. Despite their efficacy, the use of heterologous antivenoms involves the possibility ...
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