crystal structures
Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP.
... 59-nucleotidases catalyze the hydrolytic dephosphorylation of nucleoside monophosphates. As catabolic enzymes they contribute significantly to the regulation of cellular nucleotide levels; misregulation of nucleotide ...
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Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation.
... the crystal structures of the FAK kinase in complex with TAE226 and 3 related bis-anilino pyrimidine ...The structures reveal that the carbonyl in the carbamoyl moiety of TAE226 and an analogous ...
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A comparison of the crystal structures of eukaryotic and bacterial SSU ribosomal RNAs reveals common structural features in the hypervariable regions.
... the crystal structures for the ...eukaryotic crystal structures are very similar to that in the bacterial crystal structure (data not ...
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High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine
... Single point mutations in human transthyretin give rise to familial amyloidotic polyneuropathy (FAP), a hereditary form of amyloidosis associated with fibrillar TTR deposits in the peripheral nerves, kidney, spleen, ...
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Crystal Structures of Xanthomonas Small Heat Shock Protein Provide a Structural Basis for an Active Molecular Chaperone Oligomer
... here crystal structures (up to ...monomer structures mainly consist of α- crystallin domain with disordered N- and C-terminal extensions, indicating that the extensions are flexible and not essential ...
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Crystal structures of lysine-preferred racemases, the non-antibiotic selectable markers for transgenic plants.
... Alr crystal structures that were complexed with PLP (PDB codes: 1SFT [9], 1BD0 [10], 1L6G [13], 1VFS [12]) as a consequence of an extensive hydrogen-bonding ...
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The crystal structures of fourN-(4-halophenyl)-4-oxo-4H-chromene-3-carboxamides
... chromene-2-carboxamides (Reis et al., 2013) and (Gomes et al., 2013), compounds (5) and (6). Previous studies concerning the structures of the chromone-2-carboxamides show that the majority have geometries similar ...
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Crystal Structures of Putative Sugar Kinases from Synechococcus Elongatus PCC 7942 and Arabidopsis Thaliana.
... The genome of the Synechococcus elongatus strain PCC 7942 encodes a putative sugar kinase (SePSK), which shares 44.9% sequence identity with the xylulose kinase-1 (AtXK-1) from Arabidopsis thaliana. Sequence alignment ...
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Crystal structures of two 6-(2-hydroxybenzoyl)-5H-thiazolo[3,2-a]pyrimidin-5-ones
... Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s ...
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Crystal structures of five 6-mercaptopurine derivatives
... Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s ...
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Peptide bond distortions from planarity: new insights from quantum mechanical calculations and peptide/protein crystal structures.
... secondary structures has already been highlighted [47,48], likely affect also peptide bond geometrical ...protein structures are not exposed to the ...
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Crystal structures of three 3,4,5-trimethoxybenzamide-based derivatives
... around the hydrogen atom van der Waals radius of 1.20 A ˚ . The wings in the graphical representation of 2 indicate that C—H interactions are more relevant in this crystal structure, highlighting the ...
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Crystal structures of three 6-substituted coumarin-3-carboxamide derivatives
... three structures, of an intramolecular N—H O hydrogen bond between the amino group of the carboxamide and the oxo group at the O2 position of the coumarin and a weak C— H O intramolecular hydrogen bond ...
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J. Braz. Chem. Soc. vol.17 número8
... Crystallographic data for the structural analyses have been deposited with the Cambridge Crystallographic Data Centre CCDC nos. CSD 610462, 610463 and 610464 for compounds 1, 2 and 3. Further details of the ...
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Quím. Nova vol.31 número5
... In the light of this interest, we here describe the synthesis and characterization of two sulfonamides derived from 8-aminoqui- noline with 4-nitrobenzenesulfonylchloride and 2,4,6-triisopro- pylbenzenesulfonyl chloride ...
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In silico study on anti-Chikungunya virus activity of hesperetin
... 3D structures of CHIKV nsP2 (3TRK) and nsP3 (3GPG) were retrieved from Protein Data Bank (PDB), whereas nsP1, nsP4 and cellular factor SPK2 were modeled using Iterative Threading Assembly Refinement (I-TASSER) ...
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Structural analysis of mitochondrial mutations reveals a role for bigenomic protein interactions in human disease.
... Complexes I, III, IV and V of the MRC have evolved elegant functional mechanisms to pump protons across the inner mitochondrial membrane by linking multiple substrates with co- factors and metallo-protein sites, while ...
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Probing molecular mechanisms of the Hsp90 chaperone: biophysical modeling identifies key regulators of functional dynamics.
... The crystal structures of the full-length Hsp90 dimer from three different species revealed a similar domain architecture, yet significant differences in the global conformational flexibility and the ...
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Compact conformations of human protein disulfide isomerase.
... In addition, we also observed significant time-dependent changes in the inter-domain distances, the angles among adjacent domains and the dihedral angle of the four domains in the simulations (Figure 3 and Movie S1). The ...
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The role of local backrub motions in evolved and designed mutations.
... high-quality crystal structures to examine differences in local backbone conformation between well-defined motif popula- tions related by a single amino acid difference, and find that the backrub motion ...
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