DNA-DAMAGE-RESPONSE
Protease activity of PprI facilitates DNA damage response: Mn2+-dependence and substrate sequence-specificity of the proteolytic reaction.
... SOS response is activated after exposure to ultravio- let, ionizing radiation or chemical mutagens ...SOS response sys- tem does not exist in Deinococcus radiodurans [27, ...regulates DNA ...
17
The role of hnRPUL1 involved in DNA damage response is related to PARP1.
... in DNA damage response, the function of hnRPUL1 is still not ...to DNA damage sites induced by laser ...to DNA damage sites in our laser system (Figure ...base ...
10
Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication.
... MVM infection led to accumulation of Nbs1 into NS1-containing APAR bodies, in contrast to the diffuse nuclear staining pattern observed in mock cells (Fig. 2A, center panel). Nbs1 has been shown to recruit ATM to sites ...
11
Toxic effect of silica nanoparticles on endothelial cells through DNA damage response via Chk1-dependent G2/M checkpoint.
... oxidative damage followed by the production of malondialdehyde (MDA) as well as the inhibition of superoxide dismutase (SOD) and glutathione peroxidase ...of DNA damage including the percentage of ...
13
Catalytic and non-catalytic roles for the mono-ADP-ribosyltransferase Arr in the mycobacterial DNA damage response.
... stringent response. The stringent response involves the production of (p)ppGpp, in part by the enzyme RelA, during nutrient, phosphate, and nucleotide deprivation, stationary phase, oxidative Figure ...the ...
12
Dysregulation of the DNA Damage Response and KMT2A Rearrangement in Fetal Liver Hematopoietic Cells.
... the DNA damage response pathway, may influence the likelihood of KMT2A rearrange- ...defective DNA damage response, is required for full leukemogenesis ...the DNA ...
18
Cell cycle control and DNA damage response of conditionally immortalized urothelial cells.
... the DNA damage response mediated by ATM is intact in these cells under both permissive and non-permissive conditions, activation of cell cycle checkpoints and apoptosis may be inhibited by the ...
11
DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity.
... to DNA damage, mutations, and ...The DNA damage response (DDR), which monitors DNA integrity, and the spindle assembly checkpoint (SAC), which responds to defects in spindle ...
28
Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells.
... fragment. DNA fragments were then separated using a 1% agarose ...and DNA was extracted using Qiaquick gel extraction kit (Qiagen, Hilden, ...T4 DNA ligase (Invitrogen, Karlsruhe, Germany) and 100 ng ...
13
Yeast transcription termination factor Rtt103 functions in DNA damage response.
... The results shown above indicated that Rtt103 is critical for DNA repair but did not follow the same pathways as Sen1, the other transcription termination factor shown to affect genome stability. In order to gain ...
13
CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response.
... The regulation of protein localization provides cells with a convenient way to modulate their functions. p19 does not contain the standard basic monopartite or bipartite nuclear localization signal usually found in ...
14
Mre11-Rad50 promotes rapid repair of DNA damage in the polyploid archaeon Haloferax volcanii by restraining homologous recombination.
... a DNA damage response that allows time for processing of DSBs, and/or arrest at a cell cycle ...the DNA damage checkpoint and re-entered the cell cycle ...increased DNA ...
12
Acute doxorubicin insult in the mouse ovary is cell- and follicle-type dependent.
... and DNA insult in the mouse ovary, identify target cells, and a define window of opportunity prior to the apoptotic response to target future acute chemoprotection ...strand DNA breaks using the ...
19
Regulation of nucleotide excision repair by nuclear lamin b1.
... effective response to DNA damage induced by UV ...UV damage by the nucleotide excision repair (NER) pathway are down- regulated in LB1 silenced cells including DDB1, CSB and ...the DNA ...
9
Chromatin relaxation-mediated induction of p19INK4d increases the ability of cells to repair damaged DNA.
... to DNA damage by activating survival pathways consisting of cell cycle checkpoints and repair ...the DNA damage response is not necessarily a direct detection of the primary DNA ...
13
Mre11 assembles linear DNA fragments into DNA damage signaling complexes.
... the DNA damage response could not be ...the response to DSB-containing DNA (Figure 1C, open ...the DNA damage response in the Mre11-depleted extract (Figure 1C, ...
11
The effects of anti-leukemia chemotherapy on LKB1-AMPK pathway functioning in acute myeloid leukemia cell lines
... nuclear DNA replication rates and consequent extreme proliferation, when compared to surrounded healthy cells [74], and therefore several anticancer agents act as inducers of DNA damage ...the ...
129
An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells.
... and DNA repair pathways may provide adaptive mechanisms contributing to acquired drug ...mediating DNA damage signaling and -repair in RPMI8226 multiple myeloma cells and its Melphalan-resistant ...
14
Initiation of genome instability and preneoplastic processes through loss of Fhit expression.
... to DNA replication ...induced DNA double-strand breaks. Using DNA combing, we observed a defect in replication fork progression in Fhit- deficient cells that stemmed primarily from fork stalling and ...
16
Environmental risk assessment and toxicity of pharmaceuticals in coastal tropical and temperate organisms
... opposite DNA double strands (Anderson et ...in DNA. Alkylation to oxygen atoms of DNA, especially at the O6-position of guanine, are also generated at lower frequency than N-alkyl adducts, however ...
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