G-Protein-Coupled
GPCRDB: information system for G protein-coupled receptors
... G protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors. They regulate a wide range of cellular processes, including the senses of taste, smell and vision, and control ...
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Anatomical transcriptome of G protein-coupled receptors leads to the identification of a novel therapeutic candidate GPR52 for psychiatric disorders.
... Many drugs of abuse and most neuropharmacological agents regulate G protein-coupled receptors (GPCRs) in the central nervous system (CNS)_ENREF_1. The striatum, in which dopamine D1 and D2 receptors ...
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Feeding and the rhodopsin family g-protein coupled receptors in nematodes and arthropods
... G-protein coupled receptors are ubiquitous and involved in many different physiological functions. The glutamate receptors are involved in synaptic plasticity and participate in numerous functions in ...
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A robust and rapid method of producing soluble, stable, and functional G-protein coupled receptors.
... G-Protein Coupled Receptor (GPCR) Gene Design Protein sequences of 9 olfactory receptors, 2 vomeronasal receptors, one trace amine-associate receptor, and one formyl peptide receptor were ...
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Feeding and the rhodopsin family G-Protein Coupled Receptors (GPCRs) in nematodes and arthropods
... rhodopsin G-protein coupled superfamily (GPCRs) play an important role in the regulation of feeding and energy homeostasis and are activated by peptide hormones produced in the brain-gut ...
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Cell wall trapping of autocrine peptides for human G-protein-coupled receptors on the yeast cell surface.
... G-protein-coupled receptors (GPCRs) regulate a wide variety of physiological processes and are important pharmaceutical targets for drug discovery. Here, we describe a unique concept based on yeast ...
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Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum.
... G protein-coupled receptor kinases (GRKs) and arrestins mediate desensitization of G protein-coupled receptors ...mediate G protein-independent signaling via ...
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FRPR-4 Is a G-Protein Coupled Neuropeptide Receptor That Regulates Behavioral Quiescence and Posture in Caenorhabditis elegans.
... Neuropeptides signal through G-protein coupled receptors (GPCRs) to regulate a broad array of animal behaviors and physiological processes. The Caenorhabditis elegans genome encodes approximately 100 ...
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Correction: G-Protein-Coupled Estrogen Receptor Agonist Suppresses Airway Inflammation in a Mouse Model of Asthma through IL-10.
... Citation: Itoga M, Konno Y, Moritoki Y, Saito Y, Ito W, Tamaki M, et al. (2015) Correction: G-Protein- Coupled Estrogen Receptor Agonist Suppresses Airway Inflammation in a Mouse Model of Asthma ...
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A broadly conserved g-protein-coupled receptor kinase phosphorylation mechanism controls Drosophila smoothened activity.
... transmembrane protein Smoothened (Smo) in its cytoplasmic ...of G-protein-coupled receptor kinases (GRKs) in Smo regulation, we mapped four clusters of phosphorylation sites in the ...
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Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease.
... platelet G pro- tein-coupled receptor genes other than P2RY12 also contributed to the bleeding ...Platelet G protein-coupled receptor genes P2RY1, F2R, F2RL3, TBXA2R and PTGIR were ...
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Modulation of voltage-gated Ca2+ channels by G protein-coupled receptors in celiac-mesenteric ganglion neurons of septic rats.
... Septic shock, the most severe complication associated with sepsis, is manifested by tissue hypoperfusion due, in part, to cardiovascular and autonomic dysfunction. In many cases, the splanchnic circulation becomes ...
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Chemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signalling.
... of G-protein-coupled receptors (GPCRs) is causally related to questions of how and where these receptors can be activated or ...specific G-protein ...of ...
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Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors.
... G-Protein Coupled Receptors (GPCRs) are important regula- tors of many physiological functions and as such have attracted a lot of pharmacological interest for their roles in numerous ...
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The N-terminal HSDCIF motif is required for cell surface trafficking and dimerization of family B G protein coupled receptor PAC1.
... B G protein coupled receptor (GPCR) mediating the most effects of ...of G protein coupled receptor homo/ heteromerization in receptor folding, maturation, trafficking, and cell ...
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Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway.
... Studies from our lab have shown that decreasing myocardial G protein–coupled receptor kinase 2 (GRK2) activity and expression can prevent heart failure progression after myocardial infarction. Since ...
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Xanthurenic acid binds to neuronal G-protein-coupled receptors that secondarily activate cationic channels in the cell line NCB-20.
... activated G-protein coupled recep- tor(s) remains to be identified, together with its possible existence in other tissues, particularly in the human ...
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NPR-9, a Galanin-Like G-Protein Coupled Receptor, and GLR-1 Regulate Interneuronal Circuitry Underlying Multisensory Integration of Environmental Cues in Caenorhabditis elegans.
... C. elegans inhabit environments that require detection of diverse stimuli to modulate loco- motion in order to avoid unfavourable conditions. In a mammalian context, a failure to appropriately integrate environmental ...
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Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1.
... Prokineticins are angiogenic hormones that activate two G protein-coupled receptors: PKR1 and PKR2. PKR1 has emerged as a critical mediator of cardiovascular homeostasis and cardioprotection. ...
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Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells.
... In most organisms, germ cells are formed distant from the somatic part of the gonad and thus have to migrate along and through a variety of tissues to reach the gonad. Transepithelial migration through the posterior ...
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