Immune-mediated
Sex bias in experimental immune-mediated, drug-induced liver injury in BALB/c mice: suggested roles for Tregs, estrogen, and IL-6.
... production in immune-mediated DILI; however whether or not estrogen has a role in modulating IL-6 is not clear. Moreover, IL- 62/2 mice have hematopoietic deficiencies that may include other cell lines such ...
15
The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans.
... By demonstrating the immunological consequences of the protective IL23R R381Q SNP we have provided further insight into the role of the IL-23/Th17 axis in immune-mediated diseases. Our study is one of the ...
10
Safety of Anti-TNF Therapies in Immune-Mediated Inflammatory Diseases: Focus on Infections and Malignancy
... for immune-mediated inflammatory diseases (IMIDs) with anti-TNFα (Infliximab, Adalimumab, Etanercept and Golimumab) from January 2000 to December 2014 in a Tertiary Hospital were ...
86
Neonatal manifestations of immune-mediated rheumatic diseases: a retrospective longitudinal study in a tertiary hospital
... Autoimmune rheumatic diseases such as systemic lupus erythematosus (SLE), anti- phospholipid syndrome (APS), rheumatoid arthritis (RA) and Sjögren’s syndrome (SS) are part of a clinical spectrum which affects women in ...
43
Personality, Brain Asymmetry, and Neuroendocrine Reactivity in Two Immune-Mediated Disorders: a Preliminary Report
... Development of some immune-mediated disorders may depend on dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. To explore neuropsychologic mechanisms in relation to the abnormal endocrine ...
15
Monocyte scintigraphy in rheumatoid arthritis: the dynamics of monocyte migration in immune-mediated inflammatory disease.
... Thus, the data indicate that in line with animal models on chronic inflammatory lesions, macrophage renewal by monocytes is slow in chronic synovitis [12–15]. Together with the previous studies showing a rapid decrease ...
6
Position paper on tuberculosis screening in patients with immune mediated inflammatory diseases candidates for biological therapy
... The main objective of this position paper is to con- tribute for the reduction of the number of cases of re- activated TB and new TB infections in patients with immune mediated inflammatory diseases who are ...
13
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.
... Genome-wide association studies (GWAS) have defined over 150 genomic regions unequivocally containing variation predisposing to immune-mediated disease. Inferring disease biology from these observations, ...
13
Biologic therapy use and pregnancy outcomes in women with immune-mediated inflammatory rheumatic diseases
... Methods: We conducted a cohort study of pregnancies reported in women with immune-mediated rheumatic diseases registered at the Rheumatic Diseases Por- tuguese Registry (Reuma.pt) and exposed to biologic ...
7
Cerebrospinal fluid neopterin analysis in neuropediatric patients: establishment of a new cut off-value for the identification of inflammatory-immune mediated processes.
... or immune-mediated diseases (n = 23), including Aicardi-Goutie`res syndrome, acute disseminated en- cephalomyelitis, Guillain Barre´ syndrome, anti-NMDA (N-methyl D-aspartate) receptor encephalitis, chronic ...
7
Risk of subsequent coronary heart disease in patients hospitalized for immune-mediated diseases: a nationwide follow-up study from Sweden.
... of immune- mediated diseases and ...hospitalized immune-mediated diseases affect the risk of hospitalization for CHD in both males and females in all studied ...
8
Mesenchymal stem cells therapy in Veterinary Medicine: useful for immune mediated disorders?
... The multipotent and non-teratogenic properties of MSCs led to initial findings stating that these cells could be clinically used to regenerate injured tissues and to treat immune-mediated disorders due to ...
40
Brazilian recommendations on the safety and effectiveness of the yellow fever vaccination in patients with chronic immune-mediated inflammatory diseases
... To date, there is no other adequate method to evaluate the response to YFV in humans besides neutralizing anti- bodies. Nevertheless, new alternatives based on the com- plex modulation of innate immune cytokines ...
15
Role of the mitochondria in immune-mediated apoptotic death of the human pancreatic β cell line βLox5.
... bLox5 cells were also susceptible to proinflammatory cytokine- mediated cell death. Treatment of these cells with the combination of rhTNFa and rhIFNc for 48 hours caused significant killing (Fig. 4); however, ...
12
Modulation of invariant natural killer T (INKT)-Cell function in immune-mediated diseases
... Activation of naïve T cells following the encounter of a specific antigen induces their proliferation and differentiation of effector functions. The nature of such effector functions is used to classify the distinct CD4 ...
48
A novel mechanism of soluble HLA-G mediated immune modulation: downregulation of T cell chemokine receptor expression and impairment of chemotaxis.
... sHLA-G is detected in sera from normal donors and is physiologically produced by myeloid cells such as monocytes and dendritic cells, as well as by activated endothelial cells[25]. Furthermore, serum sHLA-G concentration ...
13
Gender-specific effects of genetic variants within Th1 and Th17 cell-mediated immune response genes on the risk of developing rheumatoid arthritis.
... in immune response [10,33], suggests that genetic factors modulating the immune response may contribute to the sex-specific incidence ...within immune-related genes may differentially play a role in ...
12
A novel soluble immune-type receptor (SITR) in teleost fish: carp SITR is involved in the nitric oxide-mediated response to a protozoan parasite.
... innate immune receptors of the IgSF are type I transmembrane proteins containing one or more extracellular Ig- like domains, a transmembrane segment and a cytoplasmic region that may contain tyrosine residues ...
20
A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.
... TBK1 and IKK-e are downstream factors of IPS-1. We found that TBK1 and IKK-e could bind RIG-I RD. It is possible that RIG-I associates with TBK1 through IPS-1. However, Hiscott J and colleagues demonstrated that IKK-e ...
18
IgE mediated after ibuprofen
... It is possible that our patient had an underlying undiagnosed immune dyscrasia. In that case, it might be that IgE production was a byproduct of improper antigen processing or a reaction to ibuprofen as a ...
4