Macrophage Migration Inhibitor Factor (MIF)
Involvement of Src tyrosine kinase and protein kinase C in the expression of macrophage migration inhibitory factor
... Cells were lysed in 0.05 M Tris-HCl buffer, pH 8.0, containing 0.15 M sodium chloride, 0.02% sodium azide, 0.1% sodium dodecyl sulfate (SDS), 1% nonidet P (NP-40), and a Protease Inhibitor Cocktail Set ...
6
Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation.
... specific inhibitor ISO-1 reduced LC3-II ...(an inhibitor of type III PI3K), NAC (a ROS scavenger) inhibits ...oxidase inhibitor, DPI, also inhibited MIF-induced LC3 ...ATPase inhibitor that ...
9
Macrophage migration inhibitory factor inhibits the migration of cartilage end plate-derived stem cells by reacting with CD74.
... the migration of human MSCs ...the migration of CESCs ...CESCs migration is regulated in degenerate IVD, which in turn can suppress the homing of CESCs to sites of ...of migration with a ...
15
Macrophage migration inhibitory factor antagonist (p425) ameliorates kidney histopathological and functional changes in diabetic rats
... In the diabetic group animals, diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ, 50 mg per kg body weight, dissolved in saline), while the control rats were injected only with normal ...
8
Performance of diagnostic biomarkers in predicting liver fibrosis among hepatitis C virus-infected Egyptian children
... Regarding the markers associated with matrix deg- radation (metalloproteinases, MMPs and their inhibi- tors), MMPs show substrate Sp for interstitial collagen, whereas their tissue inhibitors (TIMPs) can irreversibly ...
7
Recent Updates on the Management of Medullary Thyroid Carcinoma
... Table 1 summarize phase 3 clinical trials of vandetanib and cabozantinib versus placebo in patients with advanced MTC. Vandetanib is a once-daily oral TKI that selectively targets the RET, VEGFR-2, VEGFR-3, epidermal ...
8
Effect of Shark Liver Oil on Peritoneal Murine Macrophages in Responses to Killed-Candida albicans
... on macrophage viability, 100 mg/ml of Shark Liver Oil (SLO) was applied for macrophage stimulation when cultured with ...albicans Macrophage activity was evaluated by MTT assay, after 48 ...
5
Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis.
... remained around the rete and subcapsular regions appeared to be histologically normal when observed by light microscopy. At 90 or 365 days after DTX injection, Leydig cell distribution was similar to that after 30 days ...
13
Macrophage migration inhibitory factor as an incriminating agent in vitiligo
... In the field of dermatology, MIF- a known pro-inflamma- tory cytokine with a pleiotropic spectrum of biologic function- is believed to be a detrimental factor in many inflammatory derma- tological diseases e.g. ...
6
J. bras. pneumol. vol.36 suppl.1
... 35. Lassen MR, Turpie AG, Rosencher N, Borris LC, Ageno W, Lieberman JR, et al. Late breaking clinical trial: rivaroxaban, an oral, direct factor Xa inhibitor, for the prevention of venous thromboembolism ...
5
Non-invasive imaging of tumors by monitoring autotaxin activity using an enzyme-activated near-infrared fluorogenic substrate.
... Animals were sacrificed, organs were dissected and weighed, then ex vivo fluorescence was imaged and quantified as previously described. Tumors were immediately frozen until further use. Thawed tumors were homogenized in ...
9
Avaliação da citotoxicidade do composto de inclusão de erlotinibe em hidroxipropil-beta-ciclodextrina e da hipertermia associada à cisplatina
... Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate peme[r] ...
118
Isil Fidan+ , Sevgi Yuksel, Turgut Imir, Ayse Kalkanci, Semra Kustimur, Mustafa N Ilhan
... necrosis factor-alpha (TNF-α), granulocyte-macrophage colony-stimu- lating factor (GM-CSF) on chemokine production and anticandidal activity of human ...
5
Clinics vol.70 número3
... MATERIALS/METHODS: We examined the plasma migration inhibitory factor and E-selectin levels in 87 patients who presented with chest pain at our hospital. The patients were classified into two groups ...
4
Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections
... ing factor (G-CSF) have been found to be elevated and correlated with parasitaemia in asymptomatic pregnant women in Ghana (Wilson et ...IFN-γ, migration inhibitory factor and monocyte chemotactic ...
9
Cytotoxic and toxicological effects of phthalimide derivatives on tumor and normal murine cells
... cell migration, decreased VEGF (Vascular Endothelial Growth Factor) production and MMP-9 (Matrix Metalloproteinase-9) in multiple myeloma cells in a more effective way when compared to the statins ...
18
MiR-196a promotes pancreatic cancer progression by targeting nuclear factor kappa-B-inhibitor alpha.
... To further determine the biological role of NFKBIA in pancreatic cancer, we investigated the effect of targeted knock- down of NFKBIA in PANC-1 cells. Meanwhile, as proven before, NFKBIA is a target of miR-196a, in order ...
9
The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects.
... Radioimmune precipitation lysates (150 mM NaCl, 1% Non- idet P-40, 0.5% deoxycholic acid, 0.1% SDS, 50 mM Tris-HCl (pH 8.0)) with Complete EDTA-free protease inhibitor) or the indicated protein solutions were run ...
10
The niche-derived glial cell line-derived neurotrophic factor (GDNF) induces migration of mouse spermatogonial stem/progenitor cells.
... key factor for self-renewal and differentiation of spermatogonial stem cells, both in vivo and in vitro ...directional migration of freshly selected undifferentiated spermatogonia, as well as germline stem ...
9
Galunisertib (LY2157299), a transforming growth factor- b receptor I kinase inhibitor, attenuates acute pancreatitis in rats
... progression are pro-inflammatory cytokines, chemokines, reactive oxygen species (ROS), Ca 2+ , platelet activating factor, and adenosine, as well as neuronal and vascular responses (4). Furthermore, acinar cells ...
8