Neurodegenerative disorders
Transposable elements in TDP-43-mediated neurodegenerative disorders.
... As a test of the biological specificity of our finding that TDP-43 selectively binds to TE derived transcripts, we applied the UNIQ mapping method to a CLIP-seq dataset for an unrelated RNA binding protein. For this ...
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Assessing executive dysfunction in neurodegenerative disorders: a critical review of brief neuropsychological tools
... Executive function (EF) has been defined as a multifaceted construct that involves a variety of high-level cognitive abilities such as planning, working memory, mental flexibility, and inhibition. Being able to identify ...
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Epidemic spreading model to characterize misfolded proteins propagation in aging and associated neurodegenerative disorders.
... Misfolded proteins (MP) are a key component in aging and associated neurodegenerative disorders. For example, misfolded Amyloid-ß (Aß) and tau proteins are two neuropathogenic hallmarks of Alzheimer’s ...
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Correction: Comparative Incidence of Conformational, Neurodegenerative Disorders.
... Fig 4. Reported and hypothesised (symmetrically replicated, dotted line) normalised incidence of sCJD, ALS, PD, LBD, AD, sRPNDd and AMD, assuming protracted population survival until 125 years for a substantial ...
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Pre-symptomatic testing for neurodegenerative disorders: Middle- to long-term psychopathological impact: Pruebas pre-sintomáticas de enfermedades neurodegenerativas: el impacto psicopatológico a largo plazo
... late-onset neurodegenerative diseases such as Huntington’s disease (HD), a rare disorder with a prevalence of ~1-7 in 100,000 individuals of European ancestry (Ramos et ...severe neurodegenerative evolution ...
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The role of intrinsically unstructured proteins in neurodegenerative diseases.
... of neurodegenerative disorders currently comprise of about 32 known types of different ...the neurodegenerative diseases, the common feature is misfolding and aggregation of proteins, the major ...
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Polyglutamine disorders preface
... rare neurodegenerative disorders that share a common genetic cause: they arise as a result of abnormal expansions of CAG trinucleotide sequences occurring at particular genome ...repeat-related ...
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Specific transfection of inflamed brain by macrophages: a new therapeutic strategy for neurodegenerative diseases.
... sustained catalase expression and subsequent potent anti- inflammatory and neuroprotective outcomes in PD models. Two models of brain inflammation were used, intracranial (i.c.) injections with lipopolysaccharides (LPS) ...
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Aggregation-promoting factors in neurodegenerative diseases - insights from a C. elegans model
... Neurodegenerative disorders such as Parkinson’s, Alzheimer’s and polyglutamine diseases are commonly characterized by the presence of protein aggregates in specific ...
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Potential involvement of oxidative stress in induction of diseases : actions, mechanisms and potential of natural antioxidants
... of neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, Schizophrenia and amyotrophic lateral ...of neurodegenerative disorders using animal models or in small clinical ...of ...
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Shared molecular and functional frameworks among five complex human disorders: a comparative study on interactomes linked to susceptibility genes.
... Furthermore, we elucidated the interactors linked to the gwas- genes in all five diseases and the pathway enriched in each disease- related interactome using the ToppGene suite. This tool contains a meta-database of ...
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Single-molecule technique links structural fluctuations of proteins to brain diseases.
... various neurodegenerative disorders, they are thought to undergo a structural change that triggers protein aggregation and a series of events resulting in cell ...
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Sleep disorders in pregnancy
... breathing disorders w ere not statistically different in the PG period nor in any of the trimesters of pregnancy, maybe because these symptoms are usually noticed by people in very close contact to the pregnant w ...
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Cross-national analysis of the associations among mental disorders and suicidal behavior: findings from the WHO World Mental Health Surveys.
... mental disorders are differentially associated with suicidal behavior depending on which part of the pathway to suicide was being ...However, disorders were much less useful in predicting which people with ...
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Daf-2 signaling modifies mutant SOD1 toxicity in C. elegans.
... developing neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS), we were interested in determining if DAF-2 signaling modifies disease pathology in mutant superoxide dismutase 1 (SOD1) expressing ...
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Right anterior insula: core region of hallucinations in cognitive neurodegenerative diseases.
... In our study, the presence of hallucinations in AD (or AD and DLB) was correlated with a vast anterior-posterior network, with a predominant right brain involvement. We suppose that patients have a top-down control ...
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Metabolism, oxidation and biological implications of docosahexaenoic acid in neurodegenerative diseases.
... METABOLISM, OXIDATION AND BIOLOGICAL IMPLICATIONS OF DOCOSAHEXAENOIC ACID IN NEURODEGENERATIVE DISEASES. Docosahexaenoic acid (C22:6, n-3, DHA) is a polyunsaturated fatty acid (PUFA) present in large ...
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Cerebellum and psychiatric disorders
... “anxiety disorders”, “dementia” and “attention deficit hyperactivity ...psychiatric disorders, namely schizophrenia, bipolar disorder, major depressive disorder, anxiety disorders, dementia and ...
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Allopregnanolone suppresses diabetes-induced neuropathic pain and motor deficit through inhibition of GABAA receptor down-regulation in the spinal cord of diabetic rats
... of neurodegenerative diseases (9, 10) and elicited antinociception in neuropathic situations (11), the present study was designed to evaluate the preventive effects of neurosteroid allopregnanolone in animal ...
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Received: August 16, 2017 Accepted: May 7, 2018
... Although the average age of the participants did not indicate a predominantly elderly group, when considering the standard deviation and the maximum age observed, some individuals could, along with ...
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