pathway analysis
Pathway analysis reveals common pro-survival mechanisms of metyrapone and carbenoxolone after traumatic brain injury.
... Ingenuity Pathway Analysis software (Ingenuity Systems, Redwood City, CA) and mapped to the functional networks available in the Ingenuity Pathway Knowledge ...Canonical pathway ...
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Pathway analysis of microRNA expression profile during murine osteoclastogenesis.
... KEGG pathway analysis showed that several miRNAs up- regulated during osteoclast differentiation (clusters 1, 3, and 4) were predicted to target extracellular matrix-receptor interactions, regulators of the ...
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Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases.
... the pathway analysis have predictive power in the absence of these hits (Figure 3A–C blue curves, T1D AUC^0:7, RA AUC^0:81, CD AUC^0:56) and also increase the predictive power when added to the significant ...
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Investigating ego modules and pathways in osteosarcoma by integrating the EgoNet algorithm and pathway analysis
... and pathway enrichment ...over-representation analysis in ConsensusPathDB (14), which validates the feasibility of this ...Moreover, pathway analysis has become the main method for gaining ...
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Transcriptome Profiling and Molecular Pathway Analysis of Genes in Association with Salinity Adaptation in Nile Tilapia Oreochromis niloticus.
... The identification of genes was based on the Nile tilapia genome. To provide the gene annota- tion, the nucleic acid sequences of the genes were compared to the genomes of zebrafish, human, mouse and rat based on the ...
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Identification of Personalized Chemoresistance Genes in Subtypes of Basal-Like Breast Cancer Based on Functional Differences Using Pathway Analysis.
... the drug-resistant group and the sensitive group of basal-like breast cancer. Groups 1 and 2 provide evidence for variation in the molecular basis of drug resistance. Indeed, the patients with drug-resistant basal-like ...
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Comparison of pathway analysis and constraint-based methods for cell factory design
... structural analysis fea- tured in this work reveals that inactivation of at least two subunits of the SDH system (along with further knockouts) is required to allow strongly coupled produc- tion of ...our ...
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A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information
... the pathway, a hexoki- nase (HK), was described as having different kinetic characteristics than the human ...glycolytic pathway and where these two enzymes are located (EC ...this analysis the ...
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Multiple-pathway analysis of double-strand break repair mutations in Drosophila.
... Rr3 analysis provides two pieces of information about each mutation: which pathway(s) are suppressed and which are used for compensation (Table ...a pathway in a mutant is taken to indicate a primary ...
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WikiPathways: pathway editing for the people.
... its rich, human interpretability) and the growing databases of gene and protein annotations, interactions, and experimental data. We prioritized the development of GPML based on what is already available and what is most ...
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Pathway-based analysis of a melanoma genome-wide association study: analysis of genes related to tumour-immunosuppression.
... the analysis of functional gene sets, so-called pathway-based analysis, has recently been proposed ...the analysis in an attempt to identify new risk ...behind pathway- based GWA study ...
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The Tat pathway in Listeria monocytogenes
... blot analysis and by the promoter activity determination of lmo0362 and the null activity found for lmo0361 supposed promoter ...Tat pathway functionality still remains to be ...
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Modeling cancer progression via pathway dependencies.
... In the past several decades, many genes have been discovered that govern important functions in the develop- ment of a variety of different cancers. However, biological insight from the list of genes is still limited and ...
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Wnt signalling pathway parameters for mammalian cells.
... various pathway components, such that the only change made is the use of mammalian whole cell concentrations measured here as the initial concentrations for the ...state analysis is then conducted in two ...
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Modelling and Analysis of Biochemical Signalling Pathway Cross-talk
... Feature Interaction There may be an interesting analogy with feature interactions in telecommunica- tions and software systems. Features, or services, in these systems are additional functionality (additional to the ...
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Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis.
... (mTOR)/AKT pathway has been linked to the pathophysiology of several neoplastic diseases ...this pathway can be a result of mutations in the PI3K or AKT genes, loss of phosphatase and tensin homolog (PTEN), ...
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Path analysis suggests phytoene accumulation is the key step limiting the carotenoid pathway in white carrot roots
... In the B493 x QAL population no significant $p values were observed for ζ-carotene ($p = -0.05) and lycopene ($p = -0.15), the highest $p value being $p = 1.06 for phytoene (Figure 2). There are two possible explanations ...
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RANK, RANKL and OPG signaling pathway
... The discovery of the receptor activator of nuclear factor-kB (RANK)/RANK Ligand (RANKL)/osteo- protegerin (OPG) pathway contributed to the un- derstanding of how bone formation and resorption were processed and ...
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Model-driven redox pathway manipulation for improved isobutanol production in Bacillus subtilis complemented with experimental validation and metabolic profiling analysis.
... profiling analysis were performed to provide global and profound insights into cell metabolism of isobutanol-producing Bacillus ...profiling analysis suggested that the severely imbalanced redox status ...
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Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway.
... nigrostriatal pathway of adolescent male ...nigrostriatal pathway by modulating, at a molecular level, the capacity of neurons to transport and respond to ...
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