Regulatory elements
Identification of Predictive Cis-Regulatory Elements Using a Discriminative Objective Function and a Dynamic Search Space.
... expressed regulatory programs, as similarly expressed genes can be assigned incorrectly to clusters and lower the sensitivity of the subsequent motif-finding ...for elements in co-expressed gene sets ...
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Analysis of molecular diversity and cis-regulatory elements in the promoters of lignin genes in Eucalyptus species
... orthologous regulatory regions of a single gene from several species of variable degrees of divergence and polymorphism has been the most popular and successful approach to deduce putative regulatory ...
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Genome-wide identification of regulatory elements and reconstruction of gene regulatory networks of the green alga Chlamydomonas reinhardtii under carbon deprivation.
... Lcr2, the promoter of which contains sequence motifs similar to those found in the Lcr1 promoter, suggesting that both genes may be regulated by the same or similar upstream DNA- binding protein(s) domains ensuring ...
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Big genomes facilitate the comparative identification of regulatory elements.
... In general, the borders of annotated D. melanogaster regulatory elements represent one of many possible sequence fragments with the specified activity. In most cases, a large piece of DNA (,5 kb) with the ...
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Regulatory elements in the 3 ' untranslated region of the GP82 glycoprotein are responsible for its stage-specific expression in Trypanosoma cruzi metacyclic trypomastigotes
... Transcription in trypanosomatids occurs in a constitutive fash- ion and initiates bi-directionally in regions between two divergent gene clusters (Martinez-Calvillo et al., 2003). Different sets of genes are transcribed ...
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Brain region-specific expression of MeCP2 isoforms correlates with DNA methylation within Mecp2 regulatory elements.
... MeCP2 is a critical epigenetic regulator in brain and its abnormal expression or compromised function leads to a spectrum of neurological disorders including Rett Syndrome and autism. Altered expression of the two MeCP2 ...
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Decoding a signature-based model of transcription cofactor recruitment dictated by cardinal cis-regulatory elements in proximal promoter regions.
... cis-regulatory elements that are highly enriched at 2150/+50 bp in dictating the recruitment of cofactors, in order to establish some basic ...these elements as cardinal ...cardinal elements ...
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Deciphering the cis-regulatory elements for XYR1 and CRE1 regulators in Trichoderma reesei.
... cis-regulatory elements for XYR1 and CRE1 proteins in the filamentous fungus Trichoderma reesei, two regulators that play a central role in the expression of cellulase ...cis-regulatory ...
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Genome-wide discovery of drug-dependent human liver regulatory elements.
... putative regulatory elements, functional studies are essential for the validation of such ...potential regulatory elements that encompass SNPs that are in LD with the lead GWAS SNP ...
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Regulatory elements involved in the post-transcriptional control of stage-specific gene expression in Trypanosoma cruzi - A Review
... Trypanosomatids are subjected to heat shock when they leave the insect vector and infect mammalian cells. The heat-shock response may be part of the differen- tiation process and may be a protection mechanism for ...
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Parallel Genome-wide Profiling of Coding and Non-coding RNAs to Identify Novel Regulatory Elements in Embryonic and Maturated Heart
... the regulatory network underlying heart development are tran- scription factors (TFs) and microRNAs (miRNAs), yet limited investigation of the role of miRNAs in heart development has taken ...potential ...
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Iron deprivation in synechocystis: inference of pathways, non-coding RNAs, and regulatory elements from comprehensive expression profiling
... S6). Regulatory sRNAs involved in the regulation of iron homeostasis are known from several different groups of ...a regulatory or autoregulatory function, analogous to the 361-nucleotide 59 UTR of the ...
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Composite effects of polymorphisms near multiple regulatory elements create a major-effect QTL.
... Many agriculturally, evolutionarily, and medically important characters vary in a quantitative fashion. Unfortunately, the genes and sequence variants accounting for this variation remain largely unknown due to a variety ...
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ISSN 0100-879X BIOMEDICAL SCIENCES AND CLINICAL INVESTIGATION
... negative regulatory elements in the 5’-flanking sequence (5’FS), which might modulate the gene expression in proximal tubules, and to compare this result to those reported for intestinal cell ...essential ...
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Novel sequence variations in LAMA2 and SGCG genes modulating cis-acting
... In conclusion, in this study we reported 3 novel se- quence variations in the LAMA2 and SGCG gene se- quences, two of which predicted to modulate cis-acting regulatory elements and RNA secondary structure. ...
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Nipbl and mediator cooperatively regulate gene expression to control limb development.
... Figure 9. Nipbls and Med12 play roles in regulation of higher-order chromosome conformation at the Hoxd locus in pectoral fin buds. (A) Diagram of the genomic organization at the zebrafish hoxda locus. Genes in the hoxda ...
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Culex tarsalis vitellogenin gene promoters investigated in silico and in vivo using transgenic Drosophila melanogaster.
... Despite this divergence, rtPCR indicated that all four vitellogenin promoters had similar expression profiles and were active both pre- and post-bloodmeal [25], suggesting that they may share similar ...
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The majority of primate-specific regulatory sequences are derived from transposable elements.
... Nearly half of human DNA is derived from sequences known as TEs that have successfully replicated in the genome during the evolution of our species [1]. Although the parasitic behavior of TEs was initially put forward as ...
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Genética molecular aplicada ao câncer cutâneo não melanoma.
... Thompson Genética Médica. Iglesias RA, Kindlund E, Tammi M, Wadelius C. Some microsatellites may act as novel polymorphic cis-regulatory elements through transcription factor binding. [r] ...
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Tissue-specific effects of genetic and epigenetic variation on gene regulation and splicing.
... overlap regulatory elements, but in contrast to methylation associated to genetic variation, they also highly overlap gene bodies, which could reflect different roles of DNA methylation in gene ...
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