Serine protease
Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea.
... The physiological role of SPINT2 is incompletely characterized. In mice, SPINT2 contributes to the appropriate development of the embryo as indicated by SPINT2 knockout embryos showing clefting of the embryonic ectoderm, ...
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Identification and characterization of fusolisin, the Fusobacterium nucleatum autotransporter serine protease.
... Previous annotation of the FN1426 sequence of F. nucleatum ATCC 25586 [49], showed that the start codon proposed earlier by Kapatral and colleagues [50] has been misannotated. Upon detailed analysis, we found that the ...
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The HtrA-like serine protease PepD interacts with and modulates the Mycobacterium tuberculosis 35-kDa antigen outer envelope protein.
... Tuberculosis remains a significant global health concern with estimates indicating that one-third of the world’s population is currently latently infected by the causative organism, Mycobacte- rium tuberculosis [1]. The ...
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The first serine protease inhibitor from Lasiodora sp (Araneae: Theraphosidae) hemocytes
... The final purification of EILaH was obtained by a reversed phase chromatography and the homogeneity of preparation was demon- strated by detection of a single peptide on SDS-PAGE and a single molecular mass by MALDI-TOF, ...
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Kn-Ba: a novel serine protease isolated from Bitis arietans snake venom with fibrinogenolytic and kinin-releasing activities
... venom serine proteases (SVSPs) constitute one of the most important components [3, ...4]. Serine pro- teases from snake venoms are classified into clan PA, S1 family of chymotrypsin, and present the ...
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Kinetic characterization of gyroxin, a serine protease from Crotalus durissus terrificus venom
... This work describes for the first time the characterization of the enzymatic features of gyroxin, a serine protease from Crotalus durissus terrificus venom, capable to induce barrel rotation syndrome in ...
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Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways
... The present study aimed to assess whether Bothrops jararacussu and Bothrops pirajai crude venoms and their isolated toxins, namely serine protease (BjussuSP-I) and L-amino acid oxidase ([r] ...
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Expression of a serine protease gene prC is up-regulated by oxidative stress in the fungus Clonostachys rosea: implications for fungal survival.
... Background: Soil fungi face a variety of environmental stresses such as UV light, high temperature, and heavy metals. Adaptation of gene expression through transcriptional regulation is a key mechanism in fungal response ...
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Assessment and partial purification of serine protease inhibitors from Rhipicephalus (Boophilus) annulatus larvae
... Serine protease inhibitors are classified into at least 18 families based on the primary and three-dimensional structures and inhibition mechanisms (LASKOWSKI; QASIM, ...purified serine ...
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HATL5: a cell surface serine protease differentially expressed in epithelial cancers.
... active serine protease domain was produced in yeast using a Pichia Expression Kit (Invitrogen, Life Technologies, Grand Island, ...HATL5 serine protease sequence from the pcDNA ...HATL5 ...
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Crystallization of bothrombin, a fibrinogen-converting serine protease isolated from the venom of Bothrops jararaca
... snake-venom serine protease, speci®cally cleaves ®brinogen, releasing ®brinopeptide A to form non-crosslinked soft clots, aggregates platelets in the presence of exogeneous ®brinogen and activates blood ...
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Characterization, subsite mapping and N-terminal sequence of miliin, a serine-protease isolated from the latex of Euphorbia milii
... (Val, Pro and Ile) and defines the cleavage site. This work is the first one that reports subsite mapping of Euphorbiacea proteases. The N-terminal sequence showed higher similarity (40%) with the serine ...
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Interaction of protein C inhibitor with the type II transmembrane serine protease enteropeptidase.
... As mentioned above, native EP is a type II transmembrane serine protease. It contains an N-terminal hydrophobic segment from position 18 to 44, predicted to span the membrane [49,50]. The recombinant EP ...
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The Serine Protease EspC from Enteropathogenic Escherichia coli Regulates Pore Formation and Cytotoxicity Mediated by the Type III Secretion System.
... the serine protease inhibitor PMSF, or with the ΔespC mutant complemented with the protease deficient EspC-S256I, the levels of secreted EspD were comparable to those observed for the ΔespC mutant, ...
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Structural Characterization of Serine Protease Complexes with Novel Inhibitors
... Human Neutrophil Elastase (HNE) is a serine protease responsible for cleavage of peptide bonds conferring elasticity to the connecting tissues. For this reason, this enzyme is mainly found in the lungs, ...
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Frequência de tabagismo e das mutações N34S e P55S do gene Serine Protease Inhibitor...
... Em 2000, a análise de pacientes com pancreatite, nos quais não foram identificadas mutações no gene PRSS1, permitiu a identificação da mutação N34S no exon 3 do gene SPINK1 (serine protease inhibitor Kazal ...
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Biochemical Aspects of a Serine Protease from Caesalpinia echinata Lam. (Brazilwood) Seeds: A Potential Tool to Access the Mobilization of Seed Storage Proteins
... plant protease inhibitors belonging to Kunitz and Bowman-Birk trypsin inhibitor fa- milies [11] function as storage proteins in ...cysteine, serine, aspartyl, or metallo proteases deposited, during seed ...
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Purification and characterization of a serine protease from Alternaria alternata
... (e.g. serine proteases), extensive cross-reactivity was demonstrated, making these proteins fungal pan- allergens ...in serine proteases family, associated to date with Alternaria provide one of the targets ...
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Cloning, expression and characterisation of an HtrA-like serine protease produced in vivo by Mycobacterium leprae
... a serine protease, displaying the physicochem- ical characteristics typical of an HtrA ...showed serine protease activity towards β-casein and chaperone ...
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