Small interfering
Inhibition of Hepatitis C Virus in Mice by a Small Interfering RNA Targeting a Highly Conserved Sequence in Viral IRES Pseudoknot.
... of 341 nucleotides (nts) in length contains an internal ribosomal entry site (IRES) that consists of four stem-loop (SL) structures followed by a translational initiation codon for the viral poly- peptides [9, 10]. Among ...
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Functional specialization of the small interfering RNA pathway in response to virus infection.
... In Drosophila, post-transcriptional gene silencing occurs when exogenous or endogenous double stranded RNA (dsRNA) is processed into small interfering RNAs (siRNAs) by Dicer-2 (Dcr-2) in association with a ...
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Alpha-synuclein suppression by targeted small interfering RNA in the primate substantia nigra.
... The protein a-synuclein is involved in the pathogenesis of Parkinson’s disease and other neurodegenerative disorders. Its toxic potential appears to be enhanced by increased protein expression, providing a compelling ...
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Small interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer model.
... Small tyrosine kinase inhibitors and antibodies to IGF-IR aimed to block tumor growth in vivo are already tested in clinical trials. Inhibition of IGF-IR/IGF-I expression by nucleic acid based strategies could ...
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Systemic delivery of small interfering RNA targeting the interleukin-2/15 receptor β chain prevents disease progression in experimental arthritis.
... Nanoparticles are usually taken up by liver, spleen and other parts of the reticuloendothelial system (RES). On the other hand, small particles can easily penetrate kidney’s filtering systems. To determine tissue ...
9
Yue-feng Du1 , Liang Liang1 , Ying Shi2 , Qing-zhi Long
... multi-target small interfering RNA (siRNA) target- ing at the conservative region of human DNMT3 family proteins to the human prostate cancer cell line TSU-PR1, and then record and analyze subsequent ...
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Up-regulation of hepatoma-derived growth factor facilitates tumor progression in malignant melanoma [corrected].
... To investigate the correlation of HDGF expression with tumor progression, we assessed the effects of HDGF inhibition on melanoma using small interfering RNA (shRNA) in human A375 and A20[r] ...
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Inhibition of cytohesin-1 by siRNA leads to reduced IGFR signaling in prostate cancer
... ) small interfering RNA (siRNA) influences the insulin-like growth factor receptor (IGFR)- associated signal transduction in prostate cancer, we transfected human prostate cancer PC-3 cell lines with ...
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RNA interference of gonadotropin-inhibitory hormone gene induces arousal in songbirds.
... of small interfering RNA against GnIH precursor mRNA into the third ventricle of male and female birds reduced resting time, spontaneous production of complex vocalizations, and stimulated brief agonistic ...
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Ubiquitination is required for effective replication of coxsackievirus B3.
... by small-interfering RNA (siRNA) decreased CVB3 infection, likely through the downregulation of ubiquitination and subsequent alteration of protein function and/or ...
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Transcriptome of small regulatory RNAs in the development of the zoonotic parasite Trichinella spiralis.
... of small endogenous RNAs that have been widely identified in animals [6], plants [7], fungi [8,9] and some viruses ...endogenous small interfering RNAs (endo-siRNAs), and piwi-interacting RNAs ...
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Protective roles of pulmonary rehabilitation mixture in experimental pulmonary fibrosis in vitro and in vivo
... In TGF-b1-stimulated HLF-1 cells plus PRM 0.3 mg/mL, FGF2 and PDGF expression were decreased significantly and HLF-1 proliferation was attenuated, as shown in Figure 4C. This suggested that PRM might be due to block of ...
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Characterization and vectorization of siRNA targeting RET/PTC1 in human papillary thyroid carcinoma cells
... RET/PTC1 fusion oncogene is the most common genetic alteration identified to date in thyroid papillary carcinomas (PTC) and represents a good target for small interfering RNA (siRNA). Our aim was: i) to ...
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Therapeutic efficacy by targeting correction of Notch1-induced aberrants in uveal tumors.
... a small interfering RNA against Notch1 (siNotch1) effectively suppressed Notch1 expression, resulting in significant cell growth inhibition when combined with H101 ...
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Community storage for small urban units including dwelling and small businesses
... The consumption of electricity, in time schedule and/or in amount, in a small business and a house- hold is different, having between them distinct consumption patterns. The profile of consumption of small ...
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Arq. NeuroPsiquiatr. vol.66 número1
... functions, interfering in working conditions and family dynamics; 2) narcolepsy produces a negative so- cial impact on various spheres of patients’ lives, compro- mising instrumental activities of daily life and ...
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Braz. J. Phys. Ther. vol.15 número6
... Exercise Intolerance is a common manifestation in patients with chronic obstructive pulmonary disease (COPD), contrib- uting to the loss of functional capacity and interfering with the [r] ...
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Rev. bras. ter. intensiva vol.22 número3
... from heme degradation, enhance the endothelial function by interfering with NO bioavailability. hree cell mecha- nisms illustrating this movement were described: HO and the heme products modulate the NO expression ...
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Separomics applied to the proteomics and peptidomics of low-abundance proteins: Choice of methods and challenges – A review
... Two-dimensional electrophoresis (2-DE) is the most commonly used separation technique in proteomics for comparative and global protein analyses under differential conditions. A high number of proteins can be identified ...
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Human and plant fungal pathogens: the role of secondary metabolites.
... are small organic molecules produced by various microorganisms (mainly fungi and actino- bacteria, among others) through the action of large enzymes like nonribosomal peptide synthetases (NRPS) and polyketide ...
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