TGF-β1
Attenuation of CCl4-induced hepatic fibrosis in mice by vaccinating against TGF-β1.
... “therapeutic” for experimental hepatic fibrosis, we believe this measure will also be applicable for the treatment of hepatic fibrosis. One of the main concerns regarding the use of therapeutic vaccines for hepatic ...
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Mechanisms of Intestinal Serotonin Transporter (SERT) Upregulation by TGF-β1 Induced Non-Smad Pathways.
... [3]. TGF-β1, in particular, is an important multifunctional cytokine and a potent negative regulator of intestinal inflammation [4, ...conditions, TGF-β1 aids in epithelial defense mechanisms, ...
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The role of oxymatrine in regulating TGF-β1 in rats with hepatic fibrosis
... Results: Fibrosis was confirmed by Masson’s collagen staining. Liver TGF-β1 level was determined by ELISA. OMT significantly reduced serum ALT and AST but increased GSH levels in rats with hepatic fibrosis. ...
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Eosinophils from Murine Lamina Propria Induce Differentiation of Naive T Cells into Regulatory T Cells via TGF-β1 and Retinoic Acid.
... Anti–human TGF-β1 (Peprotech) or rat IgG1 isotype control antibody (eBioscience) was added to cultures at a final concentration of 1 ...human TGF-β1 (Pepro- tech) at varying concentrations; ...
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Improvement of tendon repair using muscle grafts transduced with TGF-β1 cDNA
... Data from several previous experimental studies confi rm the merit of this approach for delivering potentially reparative cDNAs to injured tendons. Relevant genes include those encoding BMP-12 (Lou et al., 2001; Majewski ...
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A DNA enzyme targeting Egr-1 inhibits rat vascular smooth muscle cell proliferation by down-regulation of cyclin D1 and TGF-β1
... ment with 0.1 μM ED5, there were no significant differences in p53, p21, or Bax mRNA relative to controls. However, cyclin D1 and TGF-β1 mRNA syntheses were significantly inhibited by ED5 treatment. Our ...
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Associação entre os polimorfismos dos genes MBL2, TGF-β1 e CD14 com a gravidade da doença pulmonar na fibrose cística.
... gene TGF- β1 codifica a proteína transforming growth factor β1 (TGF- β1, fator transformador de crescimento β1), a qual é membro de uma família de fatores de crescimento e ...
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TGF-β1-mediated differentiation of fibroblasts is associated with increased mitochondrial content and cellular respiration.
... fluorescence). TGF-β1-untreated cells (Fig 2A) manifested typical mor- phology of cultured fibroblasts with dendritic shape and projections extending from the main cell body expressing vimentin (Fig 2A, ...
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Expressão imuno-histoquímica de IL-17, TGF-β1 e FOXP3 em ganulomas periapicais, cistos radiculares e cistos radiculares residuais
... IL-17, TGF-β1 and FoxP3 in periapical granulomas (PGs), radicular cysts (RCs) and residual radicular cysts (RRCs), seeking a better understanding of the etiopathogenesis these ...and TGF- β1, ...
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ANTÍGENO LEUCOCITÁRIO BOVINO (BoLA) DE CLASSE I E PERFIL DE TNF-α E TGF-β1 NA PLACENTA BOVINA DURANTE A GESTAÇÃO
... and TGF-β1 (Transforming Growth Factor beta 1) cytokines in bovine non-pregnant uterus, caruncles, cotyledons and blastocysts throughout the pregnancy period, in order to understand the immune and ...
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Efeito da variabilidade genética e da concentração plasmática do fator de crescimento de transformação-β1 (TGF-β1) na fibrogénese hepática, resposta à terapêutica antiviral e história natural da Hepatite C crónica (HCC)
... Página |42 16. Nagaraja T., Chen L.,Balasubramanian A., Groopman JE., Ghoshal K., et al.(2012) Activation of the Connective Tissue Growth Factor (CTGF)-Transforming Growth Factor β1 (TGF-β1) Axis in ...
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GARP is regulated by miRNAs and controls latent TGF-β1 production by human regulatory T cells.
... latent TGF-β1 secretion in 293 cells, but not in human Figure ...latent TGF-β1 in T ...the TGF-β1 peptide (top ...active TGF-β1, respectively (bottom panels). Total ...
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Repositório Institucional da UFPA: Correlação dos níveis séricos e dos polimorfismos nos genes de citocinas (TNF-α, INF-γ, TGF-β1 e IL-10) com a apresentação clínica da hepatite B crônica
... +874A/T, TGF β1 509C/T e IL 10 1081A/G polymorphisms and serum levels of these cytokines with the clinical presentation of hepatitis ...the TGF β1 levels were lower ( < 0,01) in ...higher ...
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TGF-β1 on induced osteogenic differentiation of human dermal fibroblast
... and TGF-β1 groups in comparison with OSTEOG and OSTEOG/TGF-β1 groups in the ALP activity and OC ...but TGF-β1 did not alter the presence of mineralized calcium phosphate ...
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Associação de polimorfismos no gene do TGF-β1 com asma, marcadores de alergia e infecções helmínticas
... o TGF-B1 tem sido descrito associado a infecções por ...de TGF- β1 por leucócitos do sangue periférico não estimulados, associada positivamente com a carga parasitária e negativamente com a ...
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Influence of IL-6, IL-8, and TGF-β1 gene polymorphisms on the risk of human papillomavirus-infection in women from Pernambuco, Brazil
... Human papillomavirus (HPV) infections are strongly associated with the development of cervical intraepithelial neoplasias and invasive cervical cancer. Polymorphisms in cytokine-encoding genes and behavioural cofactors ...
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Efeitos da terapêutica com células estaminais mesenquimatosas derivadas da medula óssea na expressão da citocina pró-fibrótica tgf-β1 no endométrio de éguas com endometrose
... Mais recentemente, tem sido demonstrado que as integrinas ligam-se e em muitos casos ativam o TGF-β1 latente, particularmente em condições de inflamação e fibrose (Henderson et al., 2013). As integrinas são ...
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TGF-β1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung cancer A549 cells, which is involved in fibrotic response to TGF-β1.
... by TGF-β1 was partly rescued by exogenous ...that TGF- β1 halts the proliferation of A549 cells by downregulating COX-2, at least to some ...Indeed, TGF-β1- treated A549 cells ...
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Expressão de TGF-β1, metaloproteinases e avaliação dos índices de proliferação celular e apoptótico nas endometrites crônicas das éguas
... do TGF-β1, a principal citocina ...de TGF-β1 e também por acelerar a degradação dos colágenos do tipo I e do tipo III promovendo a produção de ...do TGF-β têm sido amplamente testados ...
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Avaliação dos fatores de crescimento TGF-β1 E PDGF na progressão da fibrose hepática em pacientes cronicamente infectados pelo vírus da hepatite C
... O TGF-β1 é a citocina pró-fibrogênica mais potente, acelerando a fibrose hepática pelo desencadeamento da transformação das células estreladas e pela participação na cascata de sinalização intracelular e ...
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