Tissue factor
Bothrops jararaca venom metalloproteinases are essential for coagulopathy and increase plasma tissue factor levels during envenomation.
... vivo. Tissue factor (TF), a 47-kDa transmembrane protein, is the cellular receptor for plasma factor VII/VIIa, and thus is an essential component for initiating blood coagulation in ...
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Histones Induce the Procoagulant Phenotype of Endothelial Cells through Tissue Factor Up-Regulation and Thrombomodulin Down-Regulation.
... The high circulating levels of histones found in various thrombotic diseases may compro- mise the anticoagulant barrier of endothelial cells. We determined how histones affect endo- thelial procoagulant tissue ...
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Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy
... express tissue factor (TF), persist after virological suppression, and trigger the coagulation cascade by activating factor ...necrosis factor–a (TNF-a), and IL-6, ex vivo and in vitro upon ...
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Procoagulant, tissue factor-bearing microparticles in bronchoalveolar lavage of interstitial lung disease patients: an observational study.
... Coagulation factor Xa appears involved in the pathogenesis of pulmonary ...induce factor X synthesis by alveolar cells, the mechanisms of local posttranslational factor X activation are not fully ...
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Peroxisome proliferator-activated receptor-gamma agonists suppress tissue factor overexpression in rat balloon injury model with paclitaxel infusion.
... of tissue factor (TF), a primary molecule for thrombosis, and elucidated its underlying ...transcription factor, activator protein-1 (AP-1), was a pivotal target of the PPAR-c agonist to lower TF ...
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Shiga toxin and lipopolysaccharide induce platelet-leukocyte aggregates and tissue factor release, a thrombotic mechanism in hemolytic uremic syndrome.
... Directly after blood sampling unstimulated cells in whole blood showed low baseline levels of TF. TF expression was detected on 8% of platelet-monocyte aggregates (range 4–12%, 7 experiments) but not on ...
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Elevated procoagulant endothelial and tissue factor expressing microparticles in women with recurrent pregnancy loss.
... Detection of common hereditary thrombophilia markers Protein C and protein S levels in the patient’s plasma were measured by Enzyme linked Immunosorbent assay. Antithrombin levels were detected by a chromogenic substrate ...
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J. bras. pneumol. vol.34 número5 en v34n5a11
... Anticoagulant medications have direct effects on the products of system activation (thrombin and fibrin). The levels of these two substances increase as a direct or indirect consequence of the tumor; in return, they ...
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Int. braz j urol. vol.40 número4
... with tissue factor protein-inhibitor (TFPI) has reduced the in- cidence of pulmonary metastases ...coagulation factor VIIa and protease-activated re- ceptor 2 (PAR2) drives angiogenesis through the ...
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Targeting exosites on blood coagulation proteases
... through extended macromolecular interaction sites (exosites) has been documented (Fenton et al. 1988, Krishnaswamy 2005). Exosite dependent substrate recognition implies that extended surfaces on the enzyme complex, ...
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Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice.
... Methodology/Principal Findings: Immunofluorescent staining revealed significant C3d deposition in lung sections from IPAH patients and C57Bl6/J wild-type mice exposed to three weeks of chronic hypoxia to induce pulmonary ...
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Análise imunoistoquímica da expressão do fator tecidual e da densidade microvascular no câncer gástrico : correlação com fatores prognósticos e sobrevida
... We are pleased to confirm that your abstract #2111, title: IMMUNOHISTOCHEMICAL ANALYSIS OF TISSUE FACTOR EXPRESSION IN HUMAN COLORECTAL CARCINOMA: CORRELATION WITH ANGIOGENESIS, CLINICOPATHOLOGICAL ASPECTS ...
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Rev. Bras. Hematol. Hemoter. vol.25 número3
... identify tissue factor (TF) expression in peripheral blood monocytes from healthy ...major factor altering TF expression in monocytes from healthy ...
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Desenvolvimento de membranas rígidas e reabsorvíveis e sua aplicação na regeneração periodontal
... Indeed, membranes made of different biomaterials such as ePTFE [2,28], collagen [2,29], polydioxanon [2] and polylactic acid (PLA) [2,41] have been reported to favor the regeneration of class II furcation defects. ...
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Arq. Bras. Cardiol. vol.97 número6 en v97n6a19
... tyrosine-kinase receptors (RTKs), VEGFR-1 (Flt-1) and VEGFR-2 (KDR, Flk-1). The Flt-1 tyrosine-kinase receptors (VEGFR-1) are the second highest-affinity receptors for VEGF. Although not so specific, Flk-1 receptors do ...
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Neural restrictive silencer factor and choline acetyltransferase expression in cerebral tissue of Alzheimer’s Disease patients: A pilot study
... Total RNA was isolated according to the method de- scribed by Chomczynski and Sacchi (1987). Briefly, cere- bral cortical tissue was homogenized using a polytron system in the presence of Trizol (Invitrogen). ...
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Transforming growth factor β1, matrix metalloproteinase-2 and its tissue inhibitor in patients with pseudoexfoliation glaucoma/syndrome
... However, a precise etyology of this systemic disease of extracellular matrix still remains unknown, though it is con- sidered TGF 1 causes an imbalance between MMPs and their TIMPs, leading to a progressive accumulation ...
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Caracterização do perfil inflamatório e angiogênico associados ao desenvolvimento de tumores murinos
... skin tissue adjacent to these ...skin tissue adjacent to the tumor, but systemic levels of vascular endothelial growth factor (VEGF) were twice as high compared to the levels of the two other ...
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CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network.
... expression in fibroblasts (Fig. 7). Shi-wen et al proposed that an autocrine CCN2-dependent loop maintains fibrosis in scleroderma [50] and several later studies further supported this concept. For example, a strong ...
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Avaliação do efeito do Dersani® e da água de coco liofilizada no modelo cutâneo de cicatrização por segunda intenção em ratos wistar
... Healing of wounds is a cascade of cellular and molecular events which interact with one another ensuing tissue reconstruction. This study assessed the effect of a compound medium-chain triglycerides, linoleic ...
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