Traditional Chinese Medicine

Top PDF Traditional Chinese Medicine:

Establishment of a rat model for uterine leiomyomas based on Western and traditional Chinese medicine theories

Establishment of a rat model for uterine leiomyomas based on Western and traditional Chinese medicine theories

Non-pregnant female Sprague-Dawley rats with an average body weight of 200 g were provided by Chengdu Dashuo Experimental Animal Tech (China). The experi- mental animal licensing SCXK (chuan) 2013-24 and SYXK (chuan) 2014-049 were used. Rats had adaptive feeding with normal light conditions and suitable humidity and temperature for 3 days. All of the animal protocols were performed in strict accordance with the guidelines for the care and use of laboratory animals established by the Animal Ethical Committee of Chengdu University of Traditional Chinese Medicine. During the experiments, efforts were made to minimize both animal suffering and the number of animals used.
Mostrar mais

8 Ler mais

An Extract of a Formula Used in the Traditional Chinese Medicine (Buzhong Yi Qi Wan) Alters the Labeling of Blood Constituents with Technetium-99m

An Extract of a Formula Used in the Traditional Chinese Medicine (Buzhong Yi Qi Wan) Alters the Labeling of Blood Constituents with Technetium-99m

Buzhong Yi Qi Wan (Buzhong) is a medicinal herb widely used in Traditional Chinese Medicine to treat the digestive and circulatory systems. Red blood cell and plasma proteins labeled with technetium-99m (99mTc) are used in nuclear medicine. The aim of this work was to investigate the effects of an aqueous Buzhong extract on the labeling of blood constituents with 99m Tc. Heparinized blood (Wistar rats) was incubated in vitro with different Buzhong extract concentrations and 99m Tc-labeling was performed. Plasma (P) and blood cells (BC) were separated and soluble (SF-P, SF-BC) and insoluble (IF-P, IF-BC) fractions were isolated. The radioactivity on blood constituents was determined and the percentage of incorporated radioactivity (%ATI) was calculated. Buzhong extract at the highest concentrations used altered significantly (p<0.05) the %ATI in blood constituents. Substances present in the Buzhong extract could alter the cellular membrane and/or generation of free radicals that have oxidant properties modifying the labeling of blood constituents with 99m Tc.
Mostrar mais

6 Ler mais

Effect of Ultra-fine Traditional Chinese Medicine Compounds on Regulation of Lipid Metabolism and Reduction in Egg Cholesterol of Laying Hens

Effect of Ultra-fine Traditional Chinese Medicine Compounds on Regulation of Lipid Metabolism and Reduction in Egg Cholesterol of Laying Hens

This study has the objective of investigating the effects of traditional Chinese medicine prescriptions (TCM) on serum lipid, abdominal and hepatic fat percentage, cholesterol content in eggs, and mRNA expression of genes apoA I and apoB 100 . One hundred and thirty five healthy (300-day-old) layers were randomly assigned to three treatments. The hens in control group were fed with the basal diet. The hens in the experimental groups (TCM 1 and TCM 2) were fed with the basal diet supplemented with 1% TCM 1 and 1% TCM 2 respectively over a period of 60 days. Laying performance and the serum parameters relevant to fat metabolism were measured. The results showed that no significant differences were found in average daily feed intake and egg weight among three treatments. Average daily laying rate in TCM treatments was increased, and the cholesterol content in eggs was decreased. The serum triglyceride (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels in experimental treatments were decreased (p<0.05), while the serum high-density lipoprotein cholesterol (HDL-C) level was increased (p<0.05) compared to the control group. Additionally, abdominal fat percentage decreased in TCM 1 treatment (p<0.05), and hepatic fat percentage decreased in both TCM treatments (p<0.05). The expression of apolipoproteinA I (apoA I) and apolipoproteinB 100 (apoB 100 ) mRNA in the liver increased in both TCM treatments (p<0.05). These results suggest that the diet supplemented with TCM could increase the expression of apoA I and apoB 100 mRNA in the liver, and decrease lipid content in the serum, and reduce egg cholesterol in layers.
Mostrar mais

8 Ler mais

Uroporphyrinogen decarboxylase as a potential target for specific components of traditional Chinese medicine: a virtual screening and molecular dynamics study.

Uroporphyrinogen decarboxylase as a potential target for specific components of traditional Chinese medicine: a virtual screening and molecular dynamics study.

Uroporphyrinogen decarboxylase (UROD) has been suggested as a protectant against radiation for head and neck cancer (HNC). In this study, we employed traditional Chinese medicine (TCM) compounds from TCM Database@Taiwan (http://tcm. cmu.edu.tw/) to screen for drug-like candidates with potential UROD inhibition characteristics using virtual screening techniques. Isopraeroside IV, scopolin, and nodakenin exhibited the highest Dock Scores, and were predicted to have good Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) properties. Two common moieties, 2H-chromen-2- one and glucoside, were observed among the top TCM candidates. Cross comparison of the docking poses indicated that candidates formed stable interactions with key binding and catalytic residues of UROD through these two moieties. The 2H- chromen-2-one moiety enabled pi-cation interactions with Arg37 and H-bonds with Tyr164. The glucoside moiety was involved in forming H-bonds with Arg37 and Asp86. From our computational results, we propose isopraeroside IV, scopolin, and nodakenin as ligands that might exhibit drug-like inhibitory effects on UROD. The glucoside and 2H-chromen-2-one moieties may potentially be used for designing inhibitors of UROD.
Mostrar mais

10 Ler mais

Traditional Chinese medicine for neck pain and low back pain: a systematic review and meta-analysis.

Traditional Chinese medicine for neck pain and low back pain: a systematic review and meta-analysis.

Neck pain (NP) and low back pain (LBP) are common symptoms bothering people in daily life. In developed countries, more than 70% of people experience LBP [1], whereas approxi- mately two-thirds of people experience NP [2,3] at some point in their lifetimes. These two dis- orders occur most frequently among the middle-aged population, in which the proportion of females is higher than that of males [4]. A majority of the acute NP and LBP sufferers obtain spontaneous relief within days or weeks, although approximately 10% of acute NP [2] and 20% of acute LBP [5] suffers experience the condition as chronic or persistent. NP and LBP can be caused by specific pathological diseases, such as tumors, infection, fracture, and inflammation. However, the pain in most individuals (approximately 85% for LBP) [1] is non-specific, which indicates that the pain is not attributable to one of the definite above pathologies but instead to some ambiguous etiology. Conventional treatments, such as medications [6] and surgery [7], have demonstrated some efficacy. Nonetheless, these treatments were not always effective, and even had some serious adverse effects [7,8]. Consequently, to find some more effective thera- peutic methods, many individuals have turned their attention to some other treatments, such as complementary and alternative medicine (CAM). Although CAM may also have some ad- verse effects of itself, given the numerous therapeutic methods of CAM and its positive effec- tiveness to some extent, a growing number of researchers have focused on various CAM therapies, such as acupuncture, massage, exercise, and hydrotherapy [9]. Most significantly, as a type of traditional Chinese medicine (TCM), acupuncture has shown respectable efficacy and is broadly accepted internationally [10–12].
Mostrar mais

37 Ler mais

Effectiveness of traditional Chinese medicine as an adjunct therapy for Parkinson's disease: a systematic review and meta-analysis.

Effectiveness of traditional Chinese medicine as an adjunct therapy for Parkinson's disease: a systematic review and meta-analysis.

Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder worldwide; it is caused by progressive loss of dopaminergic neurons in the substantia nigra and features physical signs including distal resting tremor, bradykinesia, rigidity, asymmetric onset and non-motor symptoms [1]. However, the exact etiology and pathogenesis of PD remains elusive [2]. In Mainland China, the prevalence of PD over age of 65 years is 1.7% with a rising trend annually [3]. However, no treatment is available to effectively slow down or halt PD pro- gression [4]. Dopamine replacement therapy (DRT) is still the most effective symptomatic strategy, and levodopa is the only drug that has been reported availably to extend life expectan- cy [5]. After long-term DRT usage, however, the therapeutic effects become increasingly less beneficial, and more than 50% of patients eventually experience highly disabling fluctuations, dyskinesia and agonist-induced sleep attacks [6–9]. In traditional Chinese medicine (TCM), PD symptom was first described as shaking palsy by Huangdi Neijing (ca. 100 A.D.), and TCM has exerted an indispensable effect in medical care of PD patients for thousands of years. Good compliance for long-term use with few side effects may be the foremost merits of TCM. Re- cently, a meta-analysis demonstrated that Chinese Herb Medicine (CHM) adjuvant therapy improved the clinical symptom severity scores of PD patients with few adverse effects com- pared to Western Conventional Medication (WCM) controls [10]. TCM is a holistic system of medicine including herbal medicine, acupuncture, moxibustion, Tai Chi, tuina, dietary therapy and qigong. With unique theories of diagnosis and treatment, TCM emphasizes overall treat- ment concepts based on syndrome differentiation. Up to 2013, a considerable number of clini- cal trials examining the role of TCM in PD treatment have been performed. The goal of the present study was to assess the efficacy and safety of TCM in PD treatment and to provide ad- ditional treatment options for PD patients.
Mostrar mais

18 Ler mais

A non-biological method for screening active components against influenza virus from traditional Chinese medicine by coupling a LC column with oseltamivir molecularly imprinted polymers.

A non-biological method for screening active components against influenza virus from traditional Chinese medicine by coupling a LC column with oseltamivir molecularly imprinted polymers.

To develop a non-biological method for screening active components against influenza virus from traditional Chinese medicine (TCM) extraction, a liquid chromatography (LC) column prepared with oseltamivir molecularly imprinted polymer (OSMIP) was employed with LC-mass spectrometry (LC-MS). From chloroform extracts of compound TCM liquid preparation, we observed an affinitive component m/z 249, which was identified to be matrine following analysis of phytochemical literatures, OSMIP-LC column on-line of control compounds and MS/MS off-line. The results showed that matrine had similar bioactivities with OS against avian influenza virus H9N2 in vitro for both alleviating cytopathic effect and hemagglutination inhibition and that the stereostructures of these two compounds are similar while their two-dimensional structures were different. In addition, our results suggested that the bioactivities of those affinitive compounds were correlated with their chromatographic behaviors, in which less difference of the chromatographic behaviors might have more similar bioactivities. This indicates that matrine is a potential candidate drug to prevent or cure influenza for human or animal. In conclusion, the present study showed that molecularly imprinted polymers can be used as a non-biological method for screening active components against influenza virus from TCM.
Mostrar mais

13 Ler mais

Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits.

Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits.

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment and symptomatic intervention alternatives against AD. Smart Soup (SS), a Chinese medicine formula composed of Rhizoma Acori Tatarinowii (AT), Poria cum Radix Pini (PRP) and Radix Polygalae (RP), is a typical prescription against memory deficits. Here, we assessed the efficacy of SS against AD. Oral administration of SS ameliorated the cognitive impairment of AD transgenic mice, with reduced Ab levels, retarded Ab amyloidosis and reduced Ab-induced gliosis and neuronal loss in the brains of AD mice. Consistently, SS treatment reduced amyloid-related locomotor dysfunctions and premature death of AD transgenic Drosophila. Mechanistic studies showed that RP reduced Ab generation, whereas AT and PRP exerted neuroprotective effects against Ab. Taken together, our study indicates that SS could be effective against AD, providing a practical therapeutic strategy against the disease.
Mostrar mais

13 Ler mais

The population genetics of cultivation: domestication of a traditional Chinese medicine, Scrophularia ningpoensis Hemsl. (Scrophulariaceae).

The population genetics of cultivation: domestication of a traditional Chinese medicine, Scrophularia ningpoensis Hemsl. (Scrophulariaceae).

Scrophularia ningpoensis Hemsl. is a perennial herb native to Southeastern China. Wild populations are distributed in forests along streams, thickets, and tall grasses below alt. 1700 m and reproduce from seed [30]. Roots of this medicinal herb have a long history of widespread use in China to treat inflammation, laryngitis, tonsillitis, abscesses and constipation [31,32,33]. The first recorded use in ancient Chinese literature is from ca. 100 BC [34]. Harpagoside, angroside C, acteoside and cinnamic acid are the main bioactive components [35,36,37,38,39]. According to the Chinese Pharmacopoeia, only the root of S. ningpoensis is listed as the Radix Scrophulariae [40]. Our recent field investigations indicated that wild populations of this herb have suffered rapid declines, and the species is extirpated in many locations due to over exploitation and deterioration of habitats. An analysis of the population genetics of wild S. ningpoensis populations is important and urgent for appropriate utilization, conservation and preser- vation of the wild resources.
Mostrar mais

14 Ler mais

Sensitive and Rapid Detection of Traditional Chinese Herbs by Loop-Mediated Isothermal Amplification Method and Real-Time Fluorescence Quantitative PCR

Sensitive and Rapid Detection of Traditional Chinese Herbs by Loop-Mediated Isothermal Amplification Method and Real-Time Fluorescence Quantitative PCR

Adulterant herbal materials are threats to import and export trade and consumer safety. In this study, we established a simple and rapid examination system for the detection of Phellodendron chinense Schneid. Two detection methods, real-time fluorescence quantitative PCR (real-time PCR) and loop-mediated isothermal amplification (LAMP), were developed for traditional Chinese medicine detection, and their specificity and sensitivity were compared. The DNA of P. chinense was extracted and its special periods amplified with designed primers. Real-time PCR and LAMP experiments were conducted to test the specificity of primers in contrast to other similar species. The template concentration was diluted from 10 1 ng/µL to 10 -5 ng/µL in order to contrast sensitivity
Mostrar mais

9 Ler mais

The efficacy of Shugan Jianpi Zhixie therapy for diarrhea-predominant irritable bowel syndrome: a meta-analysis of randomized, double-blind, placebo-controlled trials.

The efficacy of Shugan Jianpi Zhixie therapy for diarrhea-predominant irritable bowel syndrome: a meta-analysis of randomized, double-blind, placebo-controlled trials.

Due to chronicity and frequency of symptoms, many patients seek alternative treatments such as traditional Chinese medicine (TCM) [8–10]. TCM is characterized by syndrome differ- entiation. In this regard, “stagnation of liver energy and deficiency of spleen” is considered to be the basic pathogenic factor of diarrhea-predominant IBS (IBS-D) [11]. Relieving the sup- pressed liver and replenishing the spleen energy for anti-diarrhea (Chinese name in pinyin “Shugan Jianpi Zhixie”) is the most important therapy in the treatment of IBS-D [12]. Tong Xie Yao Fang, an ancient formula with function of Shugan Jianpi Zhixie, has been prescribed by TCM practitioners for a long time in the treatment of IBS-D [13]. There was a systematic re- view of Tong Xie Yao Fang for IBS reported in 2006 [14]. In the review, twelve studies were in- cluded, but none of them were double-blind, placebo-controlled trials. The authors concluded that no definitive conclusions could be drawn due to the poor quality of the primary trials. Re- cently, increasing numbers of well-designed trials assessing Shugan Jianpi Zhixie therapy (SJZT) for IBS have been published [12,15–21]. However, the current state of evidence of SJZT for IBS-D has so far been unknown. Therefore, we conducted a meta-analysis of randomized, double-blind, placebo-controlled trials to determine whether SJZT is beneficial to patients with IBS-D.
Mostrar mais

12 Ler mais

Effects of herbal medicine Sijunzi decoction on rabbits after relieving intestinal obstruction

Effects of herbal medicine Sijunzi decoction on rabbits after relieving intestinal obstruction

In present study, Sijunzi decoction improved the nutritional status of rabbits after relieving the obstruction. Consumption of traditional Chinese medicine stimulates the secretion of gastric acid and proteases. It also stimulates hormones secreted by gastrointestinal mucosa cells, such as gastrin, cholecystokinin, and glucagon. These hormones promote gastrointestinal motility, increase blood flow and improve the physiological metabolic process. Sijunzi decoction increases the level of IGF-1, which stimulates growth of the intestinal mucosal barrier, upregulates the digestive enzymes, improves differentia- tion and maturation of immune cells, and improves the immune system (25).
Mostrar mais

6 Ler mais

Rev. Assoc. Med. Bras.  vol.62 número9

Rev. Assoc. Med. Bras. vol.62 número9

9. Lu AP, Jia HW, Xiao C, Lu QP. Theory of traditional Chinese medicine and therapeutic method of diseases. World J Gastroenterol. 2004; 10(13):1854-6. 10. Abe GC, Ramos PE, Fontes SV, Pradella-Hallinan M, Oliveira ASB. Tongue inspection: a protocol to integrate neurology and traditional Chinese medicine. Rev Neurocienc. 2014; 22(2):201-14.

3 Ler mais

The Role of Chinese Medicine in Cancer Care—a Critical Review

The Role of Chinese Medicine in Cancer Care—a Critical Review

Traditional Chinese medicine (TCM) have been applied in conjunction with the mainstream medical procedures to treat cancers, or even used as the main treatment methods for the past five decades, and some very promising outcomes were reported. However, it is rare that patients have the choice to add TCM into their overall management of their cancer treatment in UK [1] . As a complementary medicine, TCM has not been included in the provision of National Healthcare Service (NHS) in the UK [2] , and most patients are treated in the NHS, without a chance to select it. This limitation might be made based on information of researches many years ago, and they might not reflect the development in the recent years. Meanwhile, many practitioners in UK have reported that they treated patients with cancers and the results were very promising [3] . It is a situation need clarification. Can
Mostrar mais

6 Ler mais

A New Dammarane-type Triterpene Saponin from the Root of Aralia elata

A New Dammarane-type Triterpene Saponin from the Root of Aralia elata

Aralia elata Seem. (Araliaceae) is an ancient and well-known folk medicine in China. It is widely distributed in Asian areas and has been used as a traditional Chinese medicine for the treatment of rheumatism, diabetes, myocardial infarction, gastric ulcer, neurasthenia [1]. The total saponins of the Aralia elata have been proved to have improvement in cardiac function [2]. More than 100 triterpene saponins have been isolated from this plant, including seven dammarane-type triterpene saponins [3]. In a continuing study, we now report the compounds which are found in systematic research on chemical constituents from the root of Aralia elata.
Mostrar mais

4 Ler mais

The position of the Chinese massage (Tuina) in clinical medicine

The position of the Chinese massage (Tuina) in clinical medicine

As an example, four studies compare a combined therapy of acupuncture and other methods of traditional Chinese medi- cine, including injections into the acupuncture points 22 , intra- venous injections of purified Chinese herbs 23 and Tuina 24, 25 in comparison to Western medicine methods. Lu and Yan 25 combine acupuncture with Chinese Tuina, providing a com- parison with indometacin (25 mg twice a day for 30 days), a standard drug for migraine, and obtaining better results. Acu- puncture and adequate traditional Chinese medicine methods have presented significantly better results in the treatment of migraine in relation to the control group treated with West- ern medicine 26 . With inflammatory diseases (arthritis, coli- tis), the acupuncture is more successful in the early stage of diseases; however, in medium and late disease stadium, Tuina provides better results 27 (Table 1).
Mostrar mais

6 Ler mais

Clinics  vol.72 número4

Clinics vol.72 número4

CONCLUSION: The Meridian Energy Analysis Device is making a valuable contribution to the diagnosis of Qi-blood dysfunction. It can be assessed from short-term and long-term meridian bioenergy recordings. It is one of the few methods that allow outpatient traditional Chinese medicine diagnosis, monitoring the progress, therapeutic effect and evaluation of patient prognosis. The holistic approaches underlying the practice of traditional Chinese medicine and new trends in modern medicine toward the use of objective instruments require in-depth knowledge of the mechanisms of meridian energy, and the Meridian Energy Analysis Device can feasibly be used for understanding and interpreting traditional Chinese medicine theory, especially in view of its expansion in Western countries.
Mostrar mais

4 Ler mais

Investigation of the biosynthetic potential of endophytes in traditional Chinese anticancer herbs.

Investigation of the biosynthetic potential of endophytes in traditional Chinese anticancer herbs.

Traditional Chinese medicine encompasses a rich empirical knowledge of the use of plants for the treatment of disease. In addition, the microorganisms associated with medicinal plants are also of interest as the producers of the compounds responsible for the observed plant bioactivity. The present study has pioneered the use of genetic screening to assess the potential of endophytes to synthesize bioactive compounds, as indicated by the presence of non-ribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) genes. The total DNA extracts of 30 traditional Chinese herbs, were screened for functional genes involved in the biosynthesis of bioactive compounds. The four PCR screens were successful in targeting four bacterial PKS, six bacterial NRPS, ten fungal PKS and three fungal NRPS gene fragments. Analysis of the detected endophyte gene fragments afforded consideration of the possible bioactivity of the natural products produced by endophytes in medicinal herbs. This investigation describes a rapid method for the initial screening of medicinal herbs and has highlighted a subset of those plants that host endophytes with biosynthetic potential. These selected plants can be the focus of more comprehensive endophyte isolation and natural product studies.
Mostrar mais

12 Ler mais

Trends in the use of guideline-recommended medications and in-hospital mortality of patients with acute myocardial infarction in a Chinese population.

Trends in the use of guideline-recommended medications and in-hospital mortality of patients with acute myocardial infarction in a Chinese population.

Data in this study are electronic medical records (EMR) from hospital information system (HIS) from 17 hospitals (including both Western Medicine (WM) and Traditional Chinese Medicine (TCM) hospitals) in China, which were standardized and integrated into a central- ized data warehouse by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science. All the 17 hospitals are level 3 institutions (major tertiary referral centers in provincial capitals and major cities) [15], which spread across 7 different provinces, including Beijing, Shenzhen, Guangdong, Shanxi, Fujian, Hebei and Jilin. There is a total of 2.42 million inpatients in the database, which was collected longitudinally from 2002 to 2011. It should be noted that in China, HIS were gradually implemented after 2005. In the 17 hospi- tals of our data warehouse, only one hospital has data between 2002 and 2004, so we did not in- clude the data during this period for analysis. The majority of hospitals started to implement HIS in 2007 in our database, so the number of patients before 2007 were relatively smaller.
Mostrar mais

11 Ler mais

Pharmacokinetics Applications of Traditional Chinese Medicines

Pharmacokinetics Applications of Traditional Chinese Medicines

Traditional Chinese medicine (TCM) has been widely used in many oriental countries for thousands of years and played an indispensable role in the prevention and treatment of diseases, especially the complicated and chronic ones. It is a very complex mixture containing hundreds or thousands of different components. Pharmacokinetic study on active constituents in TCM preparations is a good way for us to explain and predict a variety of events related to the efficacy and toxicity of TCM. In the drug discovery phases, pharmacokinetics is a key to guide medicinal chemists in the optimization process of a chemical series and to assist pharmacologists to design in vivo studies. To explore the potentially bioactive components in TCM, it is necessary to further study the in vivo pharmacokinetic characteristics of multiple absorbed components and find out the optical time-course behavior to providing more substantial research for new leads in drug discovery. Pharmacokinetics screening method could provide a reliable means of prospecting natural products in the search for new leads in drug discovery. This review summarizes the research progress of PK on TCM in the search for suitable lead compounds in recent years.
Mostrar mais

6 Ler mais

Show all 2976 documents...