Transcriptional Activation
Versatility of cooperative transcriptional activation: a thermodynamical modeling analysis for greater-than-additive and less-than-additive effects.
... cooperative activation in general, and in particular greater-than-additive ...the transcriptional machinery may result in greater-than-additive ...cooperative transcriptional activation is ...
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Pregnancy induces transcriptional activation of the peripheral innate immune system and increases oxidative DNA damage among healthy third trimester pregnant women.
... indicating transcriptional activation, rather than suppression, of individual ...The activation of peripheral neutrophils (and the innate immune system) during the last third of human pregnancy may ...
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Viral retasking of hBre1/RNF20 to recruit hPaf1 for transcriptional activation.
... facilitates transcriptional activation, specifically via recruitment and modulation by the N-terminus of ...dependent activation of viral early gene ...II transcriptional regulation, primarily ...
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Transcriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression.
... the transcriptional activation, that occurs 72 hours after treatment, and only a later stimulus, characterized also by the increase of p53 mRNA levels, seems to be the starting point of the ...
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GATA2 mediates thyrotropin-releasing hormone-induced transcriptional activation of the thyrotropin β gene.
... true transcriptional activator for the TSHb gene is GATA2 but not Pit1 and that Pit1 protects GATA2 from inhibition by the suppressor region (SR) located in the 39-flanking region of GATA- REs ...of ...
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Gene specificity of suppression of transgene-mediated insertional transcriptional activation by the chicken HS4 insulator.
... oncogene activation, at least in the case of therapeutic payloads that have no known oncogenic potential, such as the globin ...oncogene activation is the inclusion of insulators/enhancer- blockers in the ...
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Functional redundancy of two Pax-like proteins in transcriptional activation of cyst wall protein genes in Giardia lamblia.
... control (Figure 9B and Table S3). Interestingly, nineteen genes were up-regulated in both the Pax2 and Pax1 overexpressing cells (Figure 9B and Table S4). Thirty genes were down-regulated in both the Pax2 and Pax1 ...
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Stress-induced PARP activation mediates recruitment of Drosophila Mi-2 to promote heat shock gene expression.
... Severe cellular stresses, such as DNA strand breaks and acute HS, must be dealt with quickly and efficiently. In both cases, a multitude of factors are rapidly recruited to orchestrate the repair of DNA and the massive ...
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Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules Is Regulated by Electrochemical Oxidation Potential
... their activation of protective ...via transcriptional activation (Lipton, 2004, 2006, ...to activation of the transcription factors Nrf2 and HSF-1, respectively (Satoh et ...
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Single-cell states in the estrogen response of breast cancer cell lines.
... a transcriptional activation and/or repression of specific subsets of genes, whose characterization will provide essential information on the molecular and genomic pathways of the hormone-responsive breast ...
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Loss of DDB1 Leads to Transcriptional p53 Pathway Activation in Proliferating Cells, Cell Cycle Deregulation, and Apoptosis in Zebrafish Embryos.
... a transcriptional partner of E2F1 [71], it could be speculated that Ddb1 is not only involved in the post-translational regulation of p21 CIP1/ WAF1 family members, but also in their transcrip- tional regulation ...
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Optical imaging of retinotopic maps in a small songbird, the zebra finch.
... light spots of varying diameters were also effective in eliciting neuronal activation, optimal responses were generated with straight edges or bars oriented perpendicular to their axis of movement. A substantial ...
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The post-transcriptional gene silencing pathway in Eucalyptus
... Post-transcriptional gene silencing (PTGS) is a conserved surveillance mechanism that identifies and cleaves double-stranded RNA molecules and their cellular cognate transcripts. The RNA silencing response is ...
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Learning transcriptional regulatory relationships using sparse graphical models.
... Understanding the organization and function of transcriptional regulatory networks by analyzing high-throughput gene expression profiles is a key problem in computational biology. The challenges in this work are ...
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Post-translational regulation of Oct4 transcriptional activity.
... Oct4 is a transcriptional regulator that can either activate or repress target gene expression, depending on the cellular context [9,10]. Oct4 messenger RNA is present in fertilized oocytes and early embryos, and ...
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The transcriptional regulatory network of Mycobacterium tuberculosis.
... In summary, the expanded TR network will be useful to provide an overview of multiple functional aspects of M.tb, and to suggest new experiments. It is also important to note (especially for future studies) that the ...
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A weakened transcriptional enhancer yields variegated gene expression.
... Identical genes in the same cellular environment are sometimes expressed differently. In some cases, including the immunoglobulin heavy chain (IgH) locus, this type of differential gene expression has been related to the ...
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Global analysis of photosynthesis transcriptional regulatory networks.
... CrpK controls expression of its predicted target genes. To independently test the role of CrpK on its predicted target genes, we conducted microarray analysis comparing the expression of a DfnrL strain to a DfnrL strain ...
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Superposition of transcriptional behaviors determines gene state.
... Similar to matching panels (a) (b) and (c) in Figure 2, panels (a), (b) and (c) of this figure show the histogram of gene expression, two resulting gamma curves, and the probability of b[r] ...
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Transcriptional Auto-Regulation of RUNX1 P1 Promoter.
... specific and combinatorial regulatory complexes allows either activation or repression of gene transcription [47–50]. For example, RUNX1 protein establishes activating or repressing com- plexes by physical ...
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