Transforming growth factor-β (TGFβ)
Dysregulation of the Transforming Growth Factor β Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia.
... Diamond Blackfan Anemia (DBA) is an inherited bone marrow failure syndrome with clinical features of red cell aplasia and variable developmental abnormalities. Most affected patients have heterozygous loss of function ...
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Gap junction reduction in cardiomyocytes following transforming growth factor- β treatment and Trypanosoma cruzi infection
... Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-β (TGF-β). This cytokine ...
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Prostaglandin E2 and Transforming Growth Factor-β Play a Critical Role in Suppression of Allergic Airway Inflammation by Adipose-Derived Stem Cells.
... Mesenchymal stem cells (MSCs) are ubiquitous multipotent cells abundant in adult bone marrow (BM) and adipose tissue [6,7]. In addition to multi-lineage differentiation potential, MSCs derived from adipose tissue (ASCs) ...
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Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling.
... Interestingly, the effect of TGFb on PARP-1 or PARP-2 ADP- ribosylation, as measured by PLA, coincided with the formation of Smad3-PARP-1/2 complexes (Fig. This suggests the possibility [r] ...
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Increased angiogenesis in primary myelofibrosis: latent transforming growth factor-β as a possible angiogenic factor
... In the present study, we showed that the mean latent TGF- 1 immunoexpression levels and degree of fibrosis were lower in the control group than in the prefibrotic PMF group (p- value < 0.01). The differences in the ...
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Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-β Induced Smad3 activation in vascular smooth muscle cell.
... import factor importin-b1 and FG- repeat containing nucleoporins such as CAN/Nup214 ...retention factor Smad anchor for receptor activation (SARA) and enhancing its association with importin-b1 ...
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T ransforming growth factor-β ( TGF-β) maintains follicular ultrastructure and stimulates preantral follicle growth in caprine ovarian tissue cultured in vitro
... The transforming growth factor- β (TGF-β) is a polypeptide belonging to the TGF-β superfamily and produced by several cell types, mainly T- cells (Knight and Glister, ...This ...
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T ransforming growth factor-β ( TGF-β) maintains follicular ultrastructure and stimulates preantral follicle growth in caprine ovarian tissue cultured in vitro
... The transforming growth factor- β (TGF-β) is a polypeptide belonging to the TGF-β superfamily and produced by several cell types, mainly T- cells (Knight and Glister, ...This ...
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Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease
... those in previous studies (Araujo-Jorge et al. 2002, Perez et al. 2011). Patients who still live in endem- ic areas or had a lower length of time since their last exposure to new T. cruzi infection may show more en- ...
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Biomechanic and histologic analysis of fibroblastic effects of tendon-to-bone healing by transforming growth factor β1 (TGF-β1) in rotator cuff tears
... previously stated that an increase in TGF-β stimulated the expression of collagen type III and I in the healing process. The purpose of the study was to determine the expression of collagen type III in the rat ...
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Long Non-Coding RNA MALAT1 Mediates Transforming Growth Factor Beta1-Induced Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells.
... Total RNAs were extracted at indicated times with a TRIzol reagent kit. The cDNA was pre- pared using the PrimeScript™ RT reagent Kit (Takara Clontech, Kyoto, Japan). Real-time PCR was performed in triplicates using ...
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Involvement of Transforming Growth Factor Beta-1 (TGFβ1) Cytokine and FOXP3 Transcription Factor Genetic Polymorphisms in Hematological Malignancies
... transcription factor FOXP3 (Forkhead Box P3), which is essential for their generation and immunosuppressive functions and is directly up regulated by TGF β ...
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Co-transfection of hepatocyte growth factor and truncated TGF-β type II receptor inhibit scar formation
... surgeons. Transforming growth factor (TGF)- b plays a key role in the process of scar ...Hepatocyte growth factor (HGF) is a multifunctional growth factor that promotes ...
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Transforming Growth Factor-β: An Indirect Inducer of Th17 Cell Differentiation both in Human and Murine System
... T cells were co-cultivated with Treg cells plus dendritic cells and stimulated with anti-CD3-antibody as well as Lipopolysaccharid (LPS) (Veldhoen et al., 2006). LPS is known as strong inducer of Th1 reactions via a ...
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Transforming growth factor beta receptor II polymorphisms are associated with Kawasaki disease
... antiproliferative factor through DAXX (a death-domain-associated protein) pathway and SMAD (homologs of both the drosophila protein, mothers against decapentaplegic [MAD] and the Caenorhabditis elegans protein ...
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Transforming growth factor-beta family members are regulated during induced luteolysis in cattle
... Kayani AR, Glister C, Knight PG. Evidence for an inhibitory role of bone morphogenetic protein(s) in the follicular-luteal transition in cattle. Reproduction. 2009;137(1):67-78. http://dx.doi.org/10.1530/REP-08-0198. ...
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Temporal Expression Pattern of the Insulin-like Growth Factor II and Fibroblast Growth Factor Transcripts in Avian Embryogenesis
... postnatal growth and plays an important role in the functioning of a healthy immune system, lymphopoiesis, myogenesis and bone growth among other physiological functions (Denley et ...
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Transforming growth factor beta 2 and heme oxygenase 1 genes are risk factors for the cerebral malaria syndrome in Angolan children.
... The sample population in this study consisted of 430 children diagnosed with malaria in the central pediatric hospital of Luanda (Angola) and the 319 uninfected apparently healthy controls, all attendees to the ...
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Healing effect of andiroba-based emulsion in cutaneous wound healing via modulation of inflammation and transforming growth factor beta 3
... Methods: The wounds were harvested on days 3, 7, 15, and 20 post-surgery. Wound contraction rate, quantitative immunohistochemistry [macrophages, myofibroblasts, capillaries, collagens (col) I and III, ...
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Transcriptional Regulation of Fibroblast Growth Factor 21 Expression
... Increased serum FGF21 concentrations are associated with obesity and insulin resistance in rodents that respond poorly to endogenous FGF21, indicating that metabolic syndrome could be the result of an FGF21-resistant ...
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