VEGFR-2
![1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 tyrosine kinase inhibitors: Synthesis, biological evaluation, and molecular modelling studies](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 tyrosine kinase inhibitors: Synthesis, biological evaluation, and molecular modelling studies
... the VEGFR-2 tyrosine kinase ...good VEGFR-2 inhibition presenting low IC 50 values (150–199 nM) in enzymatic assays, showing also a significant proliferation inhibition of VEGF-stimulated ...
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Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors
... with VEGFR-2 inhi- bitory activity already published, it is surprising that a S-linker in meta position relative to the urea moiety was not explored before by ...same VEGFR-2 binding mode with ...
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Selective flexibility of side-chain residues improves VEGFR-2 docking score using AutoDock Vina
... using VEGFR-2 as protein target. VEGFR-2 can be considered as a good candidate for this type of flexibility study as VEGFR-2 structure presents a relatively rigid conformation ...
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hSulf-1 gene exhibits anticancer efficacy through negatively regulating VEGFR-2 signaling in human cancers.
... total VEGFR-2 and phosphorylated VEGFR-2 (C), and total AKT and phosphorylated AKT (D) were identified by western blotting (left panel) and immunohistochemistry (right panel) in Ad5-hSulf1 ...
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Wild Roman chamomile extracts and phenolic compounds: enzymatic assays and molecular modelling studies with VEGFR-2 tyrosine kinase
... the VEGFR-2 inhibition activity (IC50 values higher than 40 µg mL −1 ), whereas apigenin-7-O-glucoside showed VEGFR-2 inhibition activity with the IC50 value = ...the VEGFR-2 ...
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Pioglitazone Induces Cardiomyocyte Apoptosis and Inhibits Cardiomyocyte Hypertrophy Via VEGFR-2 Signaling Pathway
... v5.3. VEGFR-2-inhibitor complex crystallographic structure (Protein Data Bank ID: 3CP9) was selected as the starting structure for predicting the binding site of pioglitazone at ...
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Clonagem e expressão dos domínios 2 e 3 do receptor KDR (VEGFR-2) humano
... A proteína alvo desse estudo é o fator de crescimento endotelial vascular (VEGF), um elemento importante para muitos processos angiogênicos. A família de VEGF inclui VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, PIGF-1 e ...
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Pioglitazona Induz Apoptose e Inibe Hipertrofia de Cardiomiócitos pela Via de Sinalização do VEGFR-2
... de VEGFR-2 apatinib (Apexbio Technology LLC, Houston, TX, EUA) sobre a proliferação celular foram medidos por contagem de células coradas por cristal violeta 24 horas após o tratamento, por um contador ...
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Estudo da vascularização em válvulas cardíacas de indivíduos saudáveis através de imunocitoquímica direccionada para VEGFR-2
... Tendo os resultados obtidos sido satisfatórios foram repetidos os procedimentos para uma válvula aórtica humana, obtida por dissecção de um proveniente de autópsia de um indivíduo do sexo masculino, entre os 30 e 35 ...
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Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway.
... of VEGFR-2 involves several important loop domains including glycine-rich loop (also refers to nucleotide binding loop) at residues 841–846, the catalytic loop at residues 1026–1033, and the activation loop ...
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Rational design of thieno[3,2-b]pyridines as potential new VEGFR-2 inhibitors based on improved docking scores.
... Heleno (Centro de Investiga9ao de Montanha, Escola Superior Agraria e Centro de Quimica da Univ. do Minho). Phenolic compounds and antioxidant activity of fruiting body a[r] ...
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Prognostic roles of cross-talk between peritumoral hepatocytes and stromal cells in hepatocellular carcinoma involving peritumoral VEGF-C, VEGFR-1 and VEGFR-3.
... mRNA, VEGFR-1 mRNA, VEGFR-2 mRNA, and VEGFR-3 mRNA in another independent cohort of 45 paired tumors and peritumoral tissues was evaluated by real-time reverse-transcription PCR (Table ...
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Estudo da angiogênese e da expressão temporal do VEGF e dos seus receptores VEGFR-1/Flt-1...
... e VEGFR-1 foram observadas em osteoblastos e osteócitos na cortical alveolar, e em fibroblastos no interior do alvéolo, com diferença estatisticamente significante apenas para VEGFR-1, onde a imunomarcação ...
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2
... de 2 anos, na Ameixoeira, a qual tem vindo a criar uma dinâmica de capacitação e promoção do espírito empreendedor (lato sensu) junto das pessoas da comunidades ou de outras pessoas cuja acção empreen- dedora ...
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2 encontro parte 2
... 4.2 EXECUÇAO DO PROJETO CONFORME PLANO 4.3 CONTROLE DE MUDANÇAS NO PROJETO 7.1 PLANEJAMENTO DE RECURSOS 7.2 ESTIMATIVA DE CUSTOS 7.3 ORÇAMENTAÇÃO DE CUSTOS 7.4 CONTROLE DE CUSTOS 5[r] ...
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2
... É calculada através da subtração dos custos do gás da receita líquida.. Não inclui os custos operacionais da empresa.[r] ...
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2
... To assess the use of supercritical fluids, e. g. in separa- tion processes like supercritical extraction [1] , a profound knowledge of the encountered phase equilibrium is required. During the last decades a lot of ...
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Contribution of the intracellular cholesterol levels for the expression of VEGF-C and VEGFR-3 in acute myeloid leukemia
... The VEGFR-3/VEGF-C axis has been related to many cancers, including leukemia, due to the promotion of cell proliferation, chemotherapy resistance and tumor ...the VEGFR-3/VEGF-C axis, contributing towards ...
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Aula 2 2° Sem Determinantes
... O determinante de uma matriz A, de ordem n >=2, é a soma dos produtos dos elementos de uma fila qualquer (linha ou coluna) pelos respectivos cofatores.. “O insucesso é[r] ...
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Encontro 2 Texto 2
... Four key points characterize the development of concertive control at ISE during the second phase: (1) The teams had to bring new members into the particular value-based social systems t[r] ...
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