[PDF] Top 20 The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi
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The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi
... by the protozoan Trypanosoma ...problem in Latin America (Ro- cha et al. 2007). The main clinical symptoms of Chagas disease are cardiac and/or digestive alterations and ... See full document
7
Synergic effect of allopurinol in combination with nitro-heterocyclic compounds against Trypanosoma cruzi.
... overcoming the limitations of the present therapeutic arsenal for Chagas ...disease. The aim of this study was to evaluate the effect of allopurinol in ... See full document
11
In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
... inhibitors of trypanothi- one reductase (Silva et al. 2010). A search in the literature revealed that there are only a few reports on these in- teresting compounds, that display ... See full document
3
Design, synthesis and the effect of 1,2,3-triazole sialylmimetic neoglycoconjugates on Trypanosoma cruzi and its cell surface trans-sialidase
... inhibition of TcTS by compounds 9–12 at 1.0 mM are in accor- dance with docking results (Section 1), despite the fact that com- pounds 9 and 10, containing galactosyl units, exhibited ... See full document
12
Synthesis, in vitro and in vivo anti-Trypanosoma cruzi and toxicological activities of nitroaromatic Schiff bases.
... examination. The liver was removed, washed with 0.9% w/v NaCl solution and fixed in 10% v/v buffered ...formalin. The tissue was embedded in a paraffin block, cut into 5-μm-thick ... See full document
9
Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study
... rapid and le- thal effect on different forms and strains of ...T. cruzi, af- fecting the bioenergetic metabolism of the ...parasite. The depletion ... See full document
12
Differential in vitro activity of the DNA topoisomerase inhibitor idarubicin against Trypanosoma rangeli and Trypanosoma cruzi
... With the exception of the anthracyclines aclarubicin and idarubicin, all other DNA topoisomerase inhibitors displayed no activity against ...values in the sub-micromolar range ... See full document
5
The role of aromatic plant compounds in the prevention and treatment of neurological disorders
... risk of chronic diseases (Landete, 2013). However, their in vivo biological activity is dependent on their bioavailability which is affected by different factors including their release from ... See full document
209
In vitro evaluation of the activity of aromatic nitrocompounds against Trypanosoma cruzi
... Blood of mice infected with trypomastigotes of the Y strain of ...T. cruzi was used in the experiments. Drug tests were made in 96 well ...µl of infected ... See full document
4
Phenotypic Screening In Vitro of Novel Aromatic Amidines against Trypanosoma cruzi
... advantage of the intrinsic fluorescent properties of diamidines to identify intracellular targets (such as kinetoplast DNA [kDNA]) of ...T. cruzi, pre- vious studies identified ... See full document
7
In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
... forms of the para- site (Mady et al. 2008, Mecca et al. 2008) and act via the production of free radicals by a metabolic ...levels of activity in the parasite, T. ... See full document
6
Infecção in vitro com Trypanosoma cruzi modifica o padrão de secreção de cardiomiócitos.
... hemoflagelado Trypanosoma cruzi é uma zoonose típica das regiões tropical e subtropical da América Latina, estendendo-se até a região sudeste dos Estados Unidos da América (Dias, ... See full document
85
Trypanosoma cruzi and Neospora caninum in
... gondii, Trypanosoma cruzi e Neospora caninum, e um questionário foi respondido pelo respectivo ...T. cruzi e Leishmania ...T. cruzi indica baixo risco ambiental e alimentar para a infecção dos ... See full document
7
TRYPANOSOMA CRUZI PROTEINS: THE APPLICATION OF
... Trypanosoma cruzi, the ethiological agent of Chagas disease, is an important human ...sequenced in several laboratories around the ...numbers of sequences such as EST’s ... See full document
17
Unlocking the in vitro anti-Trypanosoma cruzi activity of halophyte plants from the southern Portugal
... by the XtremeBio (PTDC/MAR- EST/4346/2012) and MaNaCruzi projects (bilateral project, FCT/CAPES 2358, 2014/2015) funded by FCT – Foundation for Science and Technology and Portuguese National ... See full document
7
Studies on the virulence and attenuation of Trypanosoma cruzi using immunodeficient animals
... degrees of immunosuppression for experimental ...dose and infectivity of the virulent TUL strain, as exemplified in the Figure: the higher the dose, the ... See full document
4
Screening a bacterium and its effect on the biological degumming of
... ABSTRACT: Biological degumming is an eco-friendly, efficient, high-quality and low-cost method that has become the leading bast fiber degumming ...rates and small fiber damage are ... See full document
6
Biological Parameters and Molecular Markers of Clone CL Brener - The Reference Organism of the Trypanosoma cruzi Genome Project
... that the D7a divergent domain of the 24S α ribo- somal RNA gene of ...T. cruzi presents sequence di- morphism among parasite strains (Souto & Zingales ...amplification of a ... See full document
4
Chagas cardiomyopathy : the potential effect of benznidazole treatment on diastolic dysfunction and cardiac damage in dogs chronically infected with Trypanosoma cruzi.
... represents the main cause of mortality among patients with Chagas disease, and the relevance of trypanocidal treatment to improving diastolic dysfunction is still ...doubtful. In ... See full document
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