[PDF] Top 20 Chronic graft-versus-host disease : second line therapy review

... a second explanation, ECP appears to have a deep effect in the T cells homeostasis: it seems that it reduces the stimulation of T cells, it deletes T cells and even stimulates the Treg population, restoring (or at ... See full document

... acute graft-versus-host disease (aGVHD) is a life-threatening complication associated with HLA mis- match, high recipient age, low marrow cell dose, and splenectomy [2, ...steroid ... See full document

... Both infused donor T-cells and engrafting donor T-cells seem to have a role in the development of cGVHD. The studies suggesting a role for the infused donor T-cells show a lower incidence of cGVHD in T-cell depleted ... See full document

... malignant disease itself GVHD is the most common cause of death for patients who have undergone stem cell transplantation ...[2]. Chronic GVHD can affect any organ system, especially skin, eyes and oral ... See full document

... At the end of the second year ater the transplant, she came to our clinic with a complaint of inability to have sexual inter- course. She also developed secondary amenorrhea since the transplantation. Gynecologic ... See full document

... antibiotic therapy, graft versus host disease (GVHD) are rhinosinusitis predisposing ...in chronic GVHD patients. Surgery was used to treat RS in chronic GVHD patients who ... See full document

... and chronic GVHD ...and chronic GVHD, IFD, CMV reactivation, TRM, and relapse were analyzed as cumulative incidence rates with the Fine and Gray’s proportional hazards model to compare outcomes in the ... See full document

... Results: Nine patients had polyneuropathy, 4 had muscle cramps, and 14 had both. Median onset of polyneuropathy and muscle cramps was 6 and 9 months after allogeneic hematopoietic stem cell transplantation, respectively. ... See full document

... hemoglobinopathies. Graft-versus-Host Disease (GvHD) is the major source of morbidity and mortality following ...or chronic largely depending on the length of time before disease ... See full document

... Ancillary therapy and supportive care of chronic graft-versus- host disease: national institutes of health consensus development project on criteria for clinical trials in ... See full document

... 4. Redding SW, Callander NS, Haveman CW, Leonard DL. Treatment of oral chronic graft-versus-host disease with PUVA therapy. Case report and literature review. Oral Surg ... See full document

... of chronic graft-versus-host disease and the correlation of its severity with transplant-related ...of chronic GVHD as proposed by the National Institutes of Health and based on ... See full document

... potential therapy for hematological malignancies is allogeneic hematopoietic cell transplantation ...stronger graft-versus-leukemia/lymphoma (GvL) effects occur in the presence of stronger ... See full document

... advanced disease at diagnosis, thus are not amenable to curative treatment and are candidates for systemic therapy only, with a dismal 5-year survival rate of <5% (Rossi et ...front-line ... See full document

... syndrome, chronic myeloid leukemia, severe aplastic ...acute graft-versus- host disease was similar between the two groups (p-value = ...acute graft-versus-host ... See full document

... this therapy combined with anti-CD3 will be used to determine the optimal and clinically applicable regimen and thus improve the survival of patients with ... See full document

... KEY WORDS: graft-versus-host disease, blood-brain barrier, auto immunity, cerebrospinal fluid, bone marrow transplantation, albumin.. O sistema nervoso central (SNC) é considerado um lo[r] ... See full document

... cohort, 59 out of 61 patients presented active disease, i.e., patients who had failure in previous treatments, including previous ASCT. Despite that, our population was rela- tively heterogeneous; the present ... See full document

... of chronic GVHD are similar to some collagen diseases, in which there is a deregulation of the immune system with eosinophilia, presence of autoantibodies, hypergammaglobulinemia and ...with chronic GVHD ... See full document

... were irradiated with 250 and 400 rd respectively. Animals were examined daily for clinical signs of rejection or GVHD. Blood samples were taken weekly for chimeric studies by FC and intestinal biopsies were performed ... See full document